Pharmacokinetics and tolerability of single-dose Staccato® alprazolam in adolescents with epilepsy, and population pharmacokinetic analysis to support dose selection in adolescents [0.03%]
单次服用Staccato氯硝西泮治疗癫痫青少年的药代动力学和耐受性，并支持剂量选择的群体药代动力学分析
Pavel Klein,Gewalin Aungaroon,Victor Biton et al.
Pavel Klein et al.
Objective: Staccato® alprazolam is a hand-held inhalation device that provides rapid systemic delivery of alprazolam through the intrapulmonary route. This trial explored the pharmacokinetics and tolerability of single-d...
Genetic complexity in pediatric onset epilepsy-movement disorder syndromes: Insights from a cohort of 97 subjects [0.03%]
儿童期癫痫-运动障碍综合征的遗传复杂性：来自97名受试者的启示
Davide Caputo,Roberta Solazzi,Barbara Castellotti et al.
Davide Caputo et al.
Objective: Conditions presenting with both epilepsy and movement disorders (EPIMDs) range from relatively benign cases to severe developmental encephalopathies. However, the full clinical and genetic spectrum still needs ...
Clobazam versus corticosteroid for developmental and epileptic encephalopathy with spike-wave activation in sleep ((D)EE-SWAS): Results of a multicenter observational study [0.03%]
氯硝西泮与皮质类固醇治疗伴睡眠棘波激活的发育性和癫痫性脑病：一项多中心观察性研究结果
Marleen M L van Arnhem,Linde J Vijn,Guido Rubboli et al.
Marleen M L van Arnhem et al.
Objective: Developmental and epileptic encephalopathy with spike-wave activation in sleep ((D)EE-SWAS) is associated with acquired cognitive and behavioral deficits. This international multicenter study aimed to compare c...
Building bridges: One man's mission to bring hope to life with epilepsy [0.03%]
沟通心灵：帮助癫痫患者重拾希望之人生使命
Scott Badzik,Nan Lin
Scott Badzik
A global perspective on transitioning from pediatric to adult care in epilepsy [0.03%]
全球视角下癫痫患者从儿科转至成人科治疗的过渡期护理状况
Danielle M Andrade,Nathalie Jetté,Ilakkiah Chandran et al.
Danielle M Andrade et al.
Objective: Transition planning in epilepsy is crucial to ensure continuity of care, particularly for adolescents with complex needs, yet global practices remain undefined. The International League Against Epilepsy Transit...
Climate, hyponatremia, and epilepsy: A critical signal demanding broader scrutiny [0.03%]
气候、低钠血症和癫痫：亟待更广泛审视的重要信号
Junlong Chen,Jialin Liu
Junlong Chen
Response: Letter to the Editor - Climate, hyponatremia, and epilepsy: A critical signal demanding broader scrutiny [0.03%]
作者回应：气候、低钠血症和癫痫：亟待更广泛审视的警示信号
Francesco Fortunato,Sanjay M Sisodiya,Antonio Gambardella
Francesco Fortunato
Zebrafish models of developmental epileptic encephalopathy accurately reflect clinical electrographic biomarkers [0.03%]
斑马鱼发育性癫痫性脑病模型准确地反映了临床电生理生物标志物
Paige Whyte-Fagundes,Joseane Righes Marafiga,Bingyao Zhu et al.
Paige Whyte-Fagundes et al.
Objective: Developmental epileptic encephalopathies (DEEs) are epilepsy conditions characterized by significant severity and treatment challenges. Spectral components of the encephalogram (EEG) may provide a valuable biom...
C1q neutralization during epileptogenesis attenuates complement-mediated synaptic elimination and epileptiform activity [0.03%]
补体介导的突触消除和癫痫发作样活动在痫样发作发生过程中的中和作用
Yoonyi Jeong,Hyun-Kyoung Lim,Hayeon Kim et al.
Yoonyi Jeong et al.
Objective: Accumulating evidence indicates that aberrant C1q-C3 complement signaling in microglia and astrocytes drives synaptic dysfunction and neuronal loss. C1q-mediated synaptic dysfunction disrupts neuronal circuitry...
Neuropsychological outcomes comparing traditional surgical approaches and laser interstitial thermal therapy for refractory mesial temporal lobe epilepsy: A systematic review and meta-analysis [0.03%]
常规外科手术与激光间质热疗法治疗药物难治性内侧颞叶癫痫的神经心理学结局：系统综述和meta分析
Konstantina Stavrogianni,Katerina Poprelka,Theodoros Fasilis et al.
Konstantina Stavrogianni et al.
Objective: This systematic review and meta-analysis aimed to compare neuropsychological outcomes following traditional surgical approaches and magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) in pati...