Mapping intraoperative interictal epileptiform discharges using high-resolution, thin-film cortical arrays [0.03%]
使用高分辨率薄皮层阵列绘制术中局灶性癫痫放电分布图
Katrina J Barth,Iakov Rachinskiy,Suseendrakumar Duraivel et al.
Katrina J Barth et al.
Objective: Interictal epileptiform discharges (IEDs) are transients observed on the electroencephalogram (EEG) of patients with epilepsy. IEDs have traditionally been recorded from scalp or intracranial EEG macrocontacts,...
One year of seizure freedom reduces premature death in people with epilepsy in rural China: A 10-year cohort study [0.03%]
一项针对中国农村地区癫痫患者的十年队列研究表明：一年不发作可减少早死风险
Xiaowen Zhou,Yan Ge,Bin Yang et al.
Xiaowen Zhou et al.
Objective: Epilepsy carries an increased risk of premature mortality. Although seizure freedom may reduce deaths, most population-based evidence originates from high-income countries. Data from low-income settings, such a...
Stiripentol: Unpublished results from the first phase 2 clinical trial in Lennox-Gastaut syndrome conducted in the early 1990s [0.03%]
Stiripentol：20世纪90年代Lennox-Gastaut综合征首个二期临床试验未发表的结果
Stéphane Auvin,Benjamin Serraz,Jérémie Lespinasse et al.
Stéphane Auvin et al.
Objective: This study was undertaken to present the results of an exploratory phase 2 trial of stiripentol in Lennox-Gastaut syndrome (LGS). Methods: ...
Persons with epilepsy and their caregivers understand the definition of ictal impairment of consciousness [0.03%]
癫痫患者及其看护者了解意识痫性损害的定义
Kaley J Marcinski Nascimento,Fábio A Nascimento,Torie Robinson et al.
Kaley J Marcinski Nascimento et al.
The term consciousness has been reintroduced in the updated seizure classification. Concerns have been raised that "ictal impaired consciousness" may be misunderstood by persons with epilepsy (PWEs) and their caregivers, particularly that E...
Seizure-type-specific disruption of hypercapnic cardioventilatory responses in epilepsy models [0.03%]
癫痫模型中呼吸性皮层刺激诱导的惊厥类型特异性的高碳酸血症心肺反应损伤
Ayse S Dereli,Auriane Apaire,Enrique Germany Morrison et al.
Ayse S Dereli et al.
Objective: Sudden unexpected death in epilepsy (SUDEP) is linked to respiratory and autonomic failure with post-ictal periods of prolonged hypercapnia indicative of impaired central chemoreception. Yet how interictal hype...
Exploring pathways leading to drug-resistant epilepsy for patients with cryptogenic new onset refractory status epilepticus [0.03%]
探究隐源性难治性全面性癫痫持续状态患者药物耐受型癫痫的发病机制及治疗路径研究
Aurélie Hanin,Clémence Marois,Martin Guillemaud et al.
Aurélie Hanin et al.
Objective: Cryptogenic new onset refractory status epilepticus (cNORSE) carries high risks of long-term disability and post-NORSE epilepsy, but mechanisms remain unclear. We aimed to assess the predictive value of inflamm...
Evolution of the European Medicines Agency clinical guidelines for epilepsy drug development between 2010 and 2025: A comparative analysis by the ILAE Task Force on Regulatory Affairs [0.03%]
欧洲药品管理局2010至2025年癫痫药物开发临床指南的演变：国际抗癫痫联盟监管事务工作组的比较分析
Stéphane Auvin,Alexis Arzimanoglou,Jacqueline French et al.
Stéphane Auvin et al.
Objective: The latest European Medicines Agency (EMA) guideline on the clinical investigation of medicines to treat epileptic disorders was adopted by the EMA Committee for Medicinal Products for Human Use in 2025. We com...
Impact of antiseizure medication taper on electroencephalographic dynamics in focal epilepsy: A stereoelectroencephalographic study [0.03%]
抗惊厥药物减量对局灶性癫痫脑电动力学影响的立体脑电图研究
Guoping Ren,Sana Hannan,Katharina Schiller et al.
Guoping Ren et al.
Objective: Tapering of the antiseizure medication dosage in the epilepsy monitoring unit can provoke seizures, but its effects on seizure dynamics remain poorly characterized. This study addresses three questions: (1) Doe...
Extreme cryptogenic new onset refractory status epilepticus/febrile infection-related epilepsy syndrome: Evidence of profound neuroinflammation and neuronal injury [0.03%]
极端隐源性新发难治性癫痫持续状态/发热感染相关性癫痫综合征的证据表明存在严重的神经炎症和神经元损伤
Lorenzo Muccioli,Lorenzo Ferri,Lidia Di Vito et al.
Lorenzo Muccioli et al.
Xinbing Zhang,Zachary T Sanger,Thomas Lisko et al.
Xinbing Zhang et al.
Objective: Seizure unpredictability remains a major clinical challenge for people with epilepsy. Previous works have shown that seizure risk is associated with circadian and multi-day cycles in both brain and physiologica...