Epilepsy treatment over time: The chess game analogy for choosing, adjusting, and adding antiseizure medications [0.03%]
癫痫的治疗历程：选择、调整和联用抗癫痫药物的类比——国际象棋游戏
André Palmini,André Gus,Lecio Figueira Pinto
André Palmini
Recurrent seizures have such a negative impact upon the lives of persons with epilepsy that their prevention is a constant preoccupation of neurologists. Despite the large number of antiseizure medications (ASMs) currently available and of ...
Review
Epilepsia. 2025 Nov 7. DOI:10.1111/epi.70005 2025
Anti-seizure medications in patients with post-stroke epilepsy: A survival analysis study [0.03%]
卒中后癫痫患者的抗惊厥药物治疗：生存分析研究
Ippazio Cosimo Antonazzo,Carla Fornari,Gabriele Buongarzone et al.
Ippazio Cosimo Antonazzo et al.
Objective: The role of antiseizure medications (ASMs) in patients with post-stroke epilepsy (PSE) is still debated. Although a few studies have compared the efficacy of different ASMs on mortality in patients with PSE, ov...
Restoring failed inhibition in the substantia nigra pars reticulata suppresses absence seizures in rats [0.03%]
恢复黑质网状部失败的抑制可抑制大鼠失神发作
Devin Palmer,Patrick A Forcelli
Devin Palmer
Objective: For over four decades, the substantia nigra pars reticulata (SNr) has been recognized as a critical structure in the modulation of seizure activity. Pharmacological and optogenetic inhibition of the SNr produce...
A randomized, double-blind, placebo-controlled, time-to-event study of the efficacy and safety of JNJ-40411813 in combination with levetiracetam or brivaracetam in patients with focal onset seizures [0.03%]
一项随机、双盲、安慰剂对照、以事件发生时间为终点的JNJ-40411813联合左乙拉西坦或布瓦西坦治疗局灶性发作的研究疗效和安全性研究
Jacqueline French,Magdalena Bosak,Wesley T Kerr et al.
Jacqueline French et al.
Objective: Up to 30% of people with epilepsy are refractory to current antiseizure medications (ASMs). JNJ-40411813 is a positive allosteric modulator of metabotropic glutamate 2 receptor, a presynaptic glutamate release ...
Thandar Aung,Aude Jegou,Patrick Chauvel
Thandar Aung
Objective: The transition from interictal discharges to ictal high-frequency activity (HFA) remains poorly understood. We investigated whether spike-associated high-frequency oscillations (Sp-HFOs) during interictal and p...
Electroencephalographic signal dimension provides the necessary stability of measurements for the unbiased evaluation of antiseizure medications, unlike seizure frequency: Overcoming drawbacks of seizure occurrence variability [0.03%]
脑电图信号参数可提供抗癫痫药物无偏评价所需的测量稳定性，而非发作频率：克服发作发生变异性缺陷
Massimo Rizzi,Peter J West,Annamaria Vezzani et al.
Massimo Rizzi et al.
Lennox-Gastaut syndrome unveiled: Advancing diagnosis, therapies, and advocacy-insights from the Genoa International Workshop [0.03%]
解开Lennox-Gastaut综合征之谜：诊断、治疗和倡导方面的进展——来自热那亚国际研讨会的见解
Antonella Riva,Gianluca D&#x;Onofrio,Elisabetta Amadori et al.
Antonella Riva et al.
Lennox-Gastaut syndrome (LGS) is one of the most severe, yet one of the most discussed, childhood-onset developmental and epileptic encephalopathies (DEEs). Dissent among epileptologists on the definition and minimum set of electroclinical ...
Review
Epilepsia. 2025 Oct 29. DOI:10.1111/epi.18696 2025
Enlarged perivascular spaces in the basal ganglia across epilepsy subtypes [0.03%]
基底神经节中不同癫痫亚型下的血管周围间隙扩大现象
Benjamin Sinclair,Clarissa Lin Yasuda,John-Paul Nicolo et al.
Benjamin Sinclair et al.
Objective: The glymphatic system is thought to be the brain's primary waste clearance system, responsible for eliminating soluble metabolites and proteins from the central nervous system. It consists of the cerebrospinal ...
Epilepsy in dentatorubral-pallidoluysian atrophy: A systematic review and meta-analysis [0.03%]
齿红苍白球路易体萎缩症相关性癫痫的系统评价和meta分析
Toru Horinouchi,Haruka Ishibashi,Yukako Nakagami et al.
Toru Horinouchi et al.
Objective: Dentatorubral-pallidoluysian atrophy (DRPLA) is a rare autosomal dominant neurodegenerative disease caused by a CAG repeat expansion in the ATN1 gene. The juvenile onset type often presents with epilepsy, inclu...
Olig2-specific loss-of-function Slc35a2 results in hypomyelination and spontaneous seizures [0.03%]
olig2特异性Slc35a2功能缺失导致少髓症和自发性癫痫发作
Tiffany M Bartel,Chaitali Ghosh,Kathryn Bisaha et al.
Tiffany M Bartel et al.
Objective: Malformations of cortical development represent major causes of drug-resistant epilepsy, with mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy recognized as a distinct pa...