Daily intermittent fasting is an effective multiscale treatment in preclinical models of absence epilepsy [0.03%]
间断性禁食可有效缓解失神癫痫症状：多时空尺度模型的临床前研究
Coline Rulhe,Steeve Thirard,Juri Aparicio Arias et al.
Coline Rulhe et al.
Objective: Absence epilepsy is characterized by brief but frequent seizures with loss of consciousness. Existing treatments, which come with heavy side effects, are only partially effective and do not address the associat...
Arka N Mallela,Jasmine Hect,Eliza Reedy et al.
Arka N Mallela et al.
Objective: Temporal lobectomy is effective for drug-resistant temporal lobe epilepsy (TLE), but broad resections risk neuropsychological morbidity. Stereo-electroencephalography (SEEG) supports hypothesis-driven explorati...
Penetrance of pathogenic epilepsy variants is low and shaped by common genetic background [0.03%]
致病性癫痫变异的渗透率较低，并受到常见遗传背景的影响
Remi Stevelink,M Martijn Piet,Yorgos Bos et al.
Remi Stevelink et al.
Objective: The identification of pathogenic variants in developmental epileptic encephalopathy (DEE) genes can be vital for counseling and individualized treatment. Penetrance is usually considered to be high or full, alt...
Effectiveness and implementation of an inpatient mental health care pathway at an epilepsy center: A prospective service evaluation [0.03%]
癫痫中心住院精神卫生诊疗路径的有效性和实施性：前瞻性服务评价
Rosa Michaelis,Dorothea Hölscher,Katharina Braun et al.
Rosa Michaelis et al.
Objectives: This hybrid study assessed the implementation and clinical effectiveness of a structured mental health care workflow for epilepsy. Methods: ...
Early response rates with adjunctive cenobamate in uncontrolled focal seizures: Prospective analysis of a randomized, double-blind, placebo-controlled study in a multinational Asian population [0.03%]
卡马西平添用治疗亚洲多国难治性局灶性癫痫发作患者：一项随机、双盲、安慰剂对照试验的前瞻性分析
Kensuke Kawai,Eunyeong Choe,Louis Ferrari et al.
Kensuke Kawai et al.
Objective: To examine early responses to cenobamate therapy using prospective data from a dose-response study in Asian patients with focal seizures (YKP3089C035, C035) that employed a titration regimen starting at 12.5 mg...
Impact of long-term treatment with cenobamate on concomitant usage of antiseizure medications: A real-world retrospective study in Spain [0.03%]
关于西班牙现实世界中左恩巴塔长期治疗联合使用抗癫痫药物的影响的回顾性研究
Juan María Sánchez-Caro,Roshan Hariramani Ramchandani,Iratxe Maestro Saiz et al.
Juan María Sánchez-Caro et al.
Objectives: This study explored the safety and effectiveness of adjunctive cenobamate (CNB) in patients with different levels of drug-resistant epilepsy (DRE) in a real-world setting, including its impact on the use of co...
Transforming pediatric epilepsy care: Real-world insights from a leading single-center study on vagus nerve treatment outcomes [0.03%]
儿科癫痫护理的变革：来自单中心领先真实世界研究的迷走神经治疗结果见解
Lalit Bansal,Fatima Jaafar,Anshika Kapoor et al.
Lalit Bansal et al.
Objective: Vagus nerve stimulation (VNS) is utilized increasingly in the management of drug-resistant epilepsy (DRE), yet its long-term efficacy and prognostic indicators remain incompletely understood. This study evaluat...
Clinical trajectories and medication response in TBC1D24-related epilepsies [0.03%]
TBC1D24相关性癫痫的临床病程与药物反应
Ealing Mondragon,Jan H Magielski,Bintou Bane et al.
Ealing Mondragon et al.
Objective: Biallelic variants in TBC1D24 represent a rare cause of epilepsy and neurodevelopmental disorders, including severe developmental and epileptic encephalopathies. Here, we present the first attempt to delineate ...
Extracellular vesicle proteomics identifies novel blood biomarkers for the early diagnosis of status epilepticus [0.03%]
外泌体蛋白质组学鉴定出新的血液生物标志物用于难治性癫痫持续状态的早期诊断
Estevo Santamarina,Laura Abraira,Daniel Campos-Fernández et al.
Estevo Santamarina et al.
Objective: This study was undertaken to identify novel blood-based biomarkers associated with the early diagnosis of status epilepticus (SE) by exploring proteomic alterations in plasma extracellular vesicles (EVs). ...
Maxime Lévesque,Rüdiger Köhling,Massimo Avoli
Maxime Lévesque
Spreading depolarization (SD) is a transient disruption of electrographic activity that slowly propagates through the gray matter by chemical contiguity, and it is characterized by a large depolarization of neurons and glial cells. SD, whic...
Review
Epilepsia. 2025 Nov 8. DOI:10.1111/epi.70010 2025