Interictal cardiac repolarization abnormalities improve after surgical seizure resolution in pediatric drug-resistant epilepsy [0.03%]
Ege Bozdag,Navaneethakrishna Makaram,Giovanna Sabino et al.
Ege Bozdag et al.
Objective: The current work aims to study interictal T-wave alternans (TWA), a biomarker of cardiac repolarization instability that is elevated in epilepsy, in children with drug-resistant epilepsy (DRE) and to test wheth...
Paolo Scalmani,Laura Uva,Maria Cristina Regondi et al.
Paolo Scalmani et al.
Objective: The mechanisms leading to the onset of a focal seizure are still not understood. Experimental data in animal models and patients suggest that both interneurons and principal cells contribute to focal seizure ge...
Kexian Li,Xuemei Wu,Junyan He et al.
Kexian Li et al.
Objective: Epilepsy is a common neurological disorder characterized by recurrent seizures, often resulting from an imbalance between neuronal excitation and inhibition. Loss of cerebellar Purkinje cells (PCs) has been obs...
Thalamic connectivity mirrors spatial maps of network dysfunction in nonlesional focal epilepsy [0.03%]
Joline M Fan,Ehsan Tadayon,Kiwamu Kudo et al.
Joline M Fan et al.
Objective: Focal epilepsy is increasingly conceptualized as a network disorder, yet the extent to which network dysfunction reflects a shared phenotype remains unknown. Spatially conserved patterns of network dysfunction ...
Athénaïs Genin,Alicia Janvier,Tristan Moujellil-Legagneur et al.
Athénaïs Genin et al.
Objective: Dravet syndrome (DS) is a prototypical developmental and epileptic encephalopathy caused by mutations in the SCN1A gene, leading to loss of function of the voltage-gated sodium channel Naᵥ1.1. The latter cause...
Patterns of seizure frequency reduction in clinical trial participants with lower baseline seizure frequency [0.03%]
基线发作频率较低的临床试验参与者中发作频率降低的规律
Wesley T Kerr,Advith S Reddy,Neo Kok et al.
Wesley T Kerr et al.
Objective: Inclusion and exclusion criteria of clinical trials for seizures aim to select representative participants with a high enough seizure frequency to evaluate the efficacy of treatment in a relatively short double...
KCNJ4 variants disrupt inward-rectifier potassium channel function and cause refractory epilepsy [0.03%]
KCNJ4变异破坏内向整流型钾通道的功能并引起难治性癫痫
Hu Pan,Deng Liu,Wuhen Xu et al.
Hu Pan et al.
Objective: Epilepsy is a common neurological disorder with a strong genetic basis, most frequently arising from ion channel dysfunction. Although multiple inwardly rectifying potassium (Kir) channels have been implicated ...
Arterial spin labeling performs comparably to 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography for presurgical evaluation in pediatric lesional epilepsy [0.03%]
无创性动脉自旋标记灌注成像与18F-FDG PET在儿童继发于结构性脑损伤的癫痫术前评估中的对比研究
Antonio Giulio Gennari,Dorottya Cserpan,Raimund Kottke et al.
Antonio Giulio Gennari et al.
Objective: This study was undertaken to test whether arterial spin labeling (ASL) performs comparably to 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET), the mainstay functional imaging technique, i...
Interictal and seizure-onset scalp electroencephalographic patterns in malformations of cortical development [0.03%]
皮质发育不良患者的癫痫间期及发作起始期头皮脑电图模式
Lubna Shakhatreh,Liz Edenberg P Quiles,Zhibin Chen et al.
Lubna Shakhatreh et al.
Objective: Malformations of cortical development (MCDs) are a frequent cause of drug-resistant epilepsy and a common indication for resective epilepsy surgery. As magnetic resonance imaging (MRI) lacks sensitivity for sub...
Poststroke epilepsy is associated with vascular cognitive disorder in young stroke patients: The ODYSSEY study [0.03%]
血管性认知障碍与青年卒中后癫痫的关系：ODYSSEY研究
Frederik J Reitsma,Esmée Verburgt,Mijntje M I Schellekens et al.
Frederik J Reitsma et al.
Objective: Cognitive disorder is common after stroke at a young age, especially in patients with poststroke epilepsy (PSE). Whether the causative mechanism is direct (due to epilepsy-related network alterations) or indire...