Choice of antiseizure medications and associated outcomes in Medicare beneficiaries after acute ischemic stroke [0.03%]
美国医疗保险人群中急性缺血性卒中后选择抗癫痫药物及其相关结局
Julianne D Brooks,Rafaella Cazé de Medeiros,Shuo Sun et al.
Julianne D Brooks et al.
Objective: We examined choice of outpatient epilepsy-specific antiseizure medication (ESM) after a stroke discharge and outcomes in a sample of US older adults. ...
How often do caregivers attend their child when a seizure detection device alerts for a nocturnal major motor seizure? [0.03%]
照护者在夜间强直阵挛发作监护设备报警时多久会照顾孩子一次？
Anemoon T Bosch,Franciscus S S Leijten,Roland D Thijs
Anemoon T Bosch
Objective: Development in seizure detection devices has focused mainly on detection performance. Yet, in order to serve their function in preventing harmful situations and even sudden unexpected death in epilepsy (SUDEP),...
Drug discovery and preclinical testing of drug candidates for developmental and epileptic encephalopathies [0.03%]
药物发现和候选药物的临床前试验用于发育性和癫痫性脑病
Heidrun Potschka,Daniel Pérez-Pérez
Heidrun Potschka
Drug development for developmental and epileptic encephalopathies (DEEs) follows different strategies on one hand including disease-targeting precision medicine approaches considering the genetic variants and pathomechanisms in DEEs and on ...
Review
Epilepsia. 2025 Aug 6. DOI:10.1111/epi.18581 2025
Postneonatal epilepsy after acute provoked neonatal seizures: Incidence, predictors, and clinical burden in a multicenter cohort followed through early childhood [0.03%]
急性诱发性新生儿惊厥后的 postneonatal癫痫：一项多中心队列研究的患病率、预测因素和临床负担（随访至幼儿期）
Adam L Numis,Hannah C Glass,Janet S Soul et al.
Adam L Numis et al.
Objective: Epilepsy is a known potential outcome following acute provoked neonatal seizures, but its onset, treatment patterns, and health care utilization through childhood remain poorly characterized. This study aimed t...
What matters most to people living with epilepsy? A rapid review of qualitative research relating to health outcomes [0.03%]
与癫痫共存的人最在乎什么？有关健康结果的定性研究的快速回顾
James W Mitchell,John Doherty,Rachel Batchelor et al.
James W Mitchell et al.
At present, the outcomes measured and reported in clinical trials for adults with epilepsy are heterogenous and have often not been selected in consultation with people living with epilepsy. As part of a wider project developing a core outc...
Review
Epilepsia. 2025 Aug 6. DOI:10.1111/epi.18570 2025
PAC-FOS: A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures [0.03%]
PAC-FOS：一种新型的转化一致性框架识别出预测临床局灶性发作性癫痫模型最高有效性的临床前癫痫模型
Lyndsey L Anderson,Kristopher M Kahlig,Melissa L Barker-Haliski et al.
Lyndsey L Anderson et al.
Objective: Central to the development of novel antiseizure medications (ASMs) is testing of antiseizure activity in preclinical models. Although various well-established models exist, their predictive validity across the ...
Evaluating crowdsourcing for ICU EEG annotation: A comparison with expert performance [0.03%]
评估重症监护病房EEG标注的众包方法：与专家表现的比较
Wan-Yee Kong,Fábio A Nascimento,Aaron Struck et al.
Wan-Yee Kong et al.
Objective: Detection of seizures and rhythmic or periodic patterns (SRPPs) on electroencephalography (EEG) is crucial for the diagnosis and management of patients with neurological critical illness. Although automated det...
Edmund Gilbert,Sophie Binks,Valentina Damato et al.
Edmund Gilbert et al.
Objective: Autoimmune encephalitis is a cause of brain inflammation characterized by auto-antibodies, which target cell surface neuronal proteins and lead to neuronal dysfunction. The most common form is associated with a...
Guilherme L Fialho,Katia Lin
Guilherme L Fialho
Org 34167 rescues voltage dependence of mutant channels and normalizes hyperexcitability in HCN1 epilepsy [0.03%]
组织34167挽救突变通道的电压依赖性并纠正HCN1癫痫的高兴奋性
Lauren E Bleakley,Chaseley E McKenzie,Khaing Phyu Aung et al.
Lauren E Bleakley et al.
Objective: Developmental and epileptic encephalopathies (DEEs) are severe neurological conditions typically caused by pathogenic genetic variants. Variants in HCN1 can cause DEE by disrupting channel voltage sensitivity, ...