Spectrum of epileptogenicity in different cortical tuber radiological subtypes: A stereoelectroencephalographic study [0.03%]
不同皮质结节放射学亚型的致痫光谱：立体脑电图研究
Haixiang Wang,Aileen McGonigal,Bingqing Zhang et al.
Haixiang Wang et al.
Objective: Tuberous sclerosis complex (TSC) causes focal drug-resistant epilepsy. Prediction of which tubers are epileptogenic remains challenging. We used stereoelectroencephalography (SEEG) to investigate epileptogenic ...
Early seizure freedom with [18F]fluorodopa positron emission tomography response after isocitrate dehydrogenase inhibition with vorasidenib: First case report [0.03%]
伏拉西迪尼诱导异柠檬酸脱氢酶抑制后，[18F]氟多巴正电子发射断层扫描反应早期癫痫自由：首例报道
Roberta Rudà,Francesco Bruno,Alessia Pellerino et al.
Roberta Rudà et al.
Vorasidenib, a dual isocitrate dehydrogenase 1/2 (IDH1/2) inhibitor, showed superior efficacy in prolonging progression-free survival and time to next intervention in IDH-mutant grade 2 gliomas. This case is part of an ongoing institutional...
Suspected induction of epileptic negative myoclonus after lacosamide initiation [0.03%]
拉考沙胺起始后疑似诱发的癫痫阴性肌阵挛
Naohiro Yamamoto,Ichiro Kuki,Takeshi Inoue et al.
Naohiro Yamamoto et al.
Older voltage-gated sodium channel (VGSC) blockers, such as carbamazepine and phenytoin, can increase interictal epileptiform abnormalities and induce new seizure types. However, we could find no reports for lacosamide (LCM), a newer VGSC b...
Sabrina Tavella-Burka,Patrick Hartnett,Mark Quigg
Sabrina Tavella-Burka
In 2025, the International League Against Epilepsy introduced a revised seizure classification, building on user feedback and increased knowledge of seizure mechanisms, as an update to the 1981 and 2017 classifications previously establishe...
De novo pathogenic CSF1R variant implicates microglial dysfunction in pathogenesis of febrile infection-related epilepsy syndrome [0.03%]
CSF1R新发致病突变提示微胶质细胞功能障碍与发热感染相关性癫痫综合征发病相关
Kristen S Fisher,Jesse M Levine,Alexander Ankar et al.
Kristen S Fisher et al.
Febrile infection-related epilepsy syndrome (FIRES) is a rare presentation of refractory status epilepticus following a febrile illness with resulting refractory epilepsy. Evidence supports the presence of immune dysregulation in patients w...
Danielle M Andrade,Anne S Bassett,Quratulain ZulfiqarAli et al.
Danielle M Andrade et al.
Dravet syndrome (DS) is a developmental and epileptic encephalopathy associated with pathogenic variants in the SCN1A gene. The neuropathological features of adult DS remain poorly understood. We report the postmortem findings of a 55-year-...
Evelina Carapancea,Erik A Eklund,Helene Verhelst et al.
Evelina Carapancea et al.
Disinhibition of the mechanistic target of rapamycin (mTOR) pathway has been observed in patients with loss-of-function variants in the disheveled, Egl-10, and pleckstrin domain-containing protein 5 (DEPDC5), and nitrogen permease regulator...
Clinical features and prognosis of first-ever acute symptomatic seizures due to acute systemic causes [0.03%]
由急性系统性疾病导致的首次发作症状性癫痫的临床特点及预后分析
Nicholas Lawn,William Wallefeld,Judy Lee et al.
Nicholas Lawn et al.
Objective: This study was undertaken to assess the clinical features and prognosis in patients with a first-ever acute symptomatic seizure due to an acute systemic cause (ASAS). ...
Quality of life over time after new onset refractory status epilepticus [0.03%]
新发难治性癫痫持续状态后的长期生活质量变化
Matthew D Gruen,Margaret T Gopaul,Anthony D Jimenez et al.
Matthew D Gruen et al.
Objective: This study aims to better characterize the long-term neurological quality of life (QOL) outcomes (using the Neuro-QOL scale) in survivors of new onset refractory status epilepticus (NORSE), including its subtyp...
Potassium-chloride cotransporter 2 activity dampens induced ictal-like activity in neocortical slices containing the seizure propagation zone of temporal lobe epilepsy patients [0.03%]
钾氯同向转运体2活性可抑制含癫痫患者颞叶癫痫发作传播区新皮质切片中的诱发痫样活动
Alice Falck,Janna Lehnhoff,Mahraz Behbood et al.
Alice Falck et al.
Objective: The K+/Cl- cotransporter (KCC2), which acts as the main Cl- extruder in the adult brain, coregulates the driving force and therewith indirectly the amount and polarity of γ-aminobutyric acidergic (GABAergic) c...