Diagnosing nonconvulsive status epilepticus: Defining electroencephalographic and clinical response to diagnostic intravenous antiseizure medication trials [0.03%]
诊断非惊厥性持续状态的脑电图和临床反应以进行诊断性的静脉抗癫痫药物试验
Markus Leitinger,Nicolas Gaspard,Lawrence J Hirsch et al.
Markus Leitinger et al.
Objective: The Salzburg criteria for nonconvulsive status epilepticus (NCSE) and the American Clinical Neurophysiology Society (ACNS) Standardized Critical Care EEG Terminology 2021 include a diagnostic trial with intrave...
Investigation of cardiac arrhythmia events in patients treated with lamotrigine: FDA adverse event reporing system analysis [0.03%]
拉莫三嗪治疗患者的的心律失常事件调查：来自美国食品药品监督管理局不良事件报告系统的分析
Mohammed Aboukaoud,Adi Wilf-Yarkoni,Elad Maor
Mohammed Aboukaoud
Objectives: In October 2020 and March 2021, the U.S. Food and Drug Administration (FDA) classified lamotrigine as a class IB antiarrhythmic, announcing an increased risk of heart rhythm problems. We sought to investigate ...
A cost analysis of MR-guided laser interstitial thermal therapy for adult refractory epilepsy [0.03%]
磁共振引导激光间质热疗治疗成人难治性癫痫的成本分析
Michael G Brandel,Nikhita Kunwar,Ali A Alattar et al.
Michael G Brandel et al.
Objective: MR-guided laser interstitial thermal therapy (LITT) is used increasingly for refractory epilepsy. The goal of this investigation is to directly compare cost and short-term adverse outcomes for adult refractory ...
Focal to bilateral tonic-clonic seizures predict pharmacoresistance in focal cortical dysplasia-related epilepsy [0.03%]
局灶性阵挛-癫痫持续状态发作转换为双侧 tonic-clonic 癫痫持续状态提示难治性皮质发育不良相关癫痫
Phat Chang,Hua Xie,Venkata Sita Priyanka Illapani et al.
Phat Chang et al.
Objective: Focal cortical dysplasia (FCD) is the most common etiology of surgically-remediable epilepsy in children. Eighty-seven percent of patients with FCD develop epilepsy (75% is pharmacoresistant epilepsy [PRE]). Fo...
Marc Rodrigo-Gisbert,Laura Gómez-Dabó,Manuel Quintana et al.
Marc Rodrigo-Gisbert et al.
Objective: Possible long-term consequences of status epilepticus (SE) include cognitive and behavioral impairment and the development of chronic epilepsy. However, these aspects have not been systematically studied in cli...
Development of an online calculator for the prediction of seizure freedom following pediatric hemispherectomy using the Hemispherectomy Outcome Prediction Scale (HOPS) [0.03%]
基于半球切除预后评分（HOPS）的儿童半球切除术后无发作预测在线计算系统的研发
Alexander G Weil,Evan Dimentberg,Evan Lewis et al.
Alexander G Weil et al.
Objectives: Although hemispheric surgeries are among the most effective procedures for drug-resistant epilepsy (DRE) in the pediatric population, there is a large variability in seizure outcomes at the group level. A rece...
Interictal respiratory variability predicts severity of hypoxemia after generalized convulsive seizures [0.03%]
发作间期呼吸变异性的变化可预测全面性强直阵挛性发作后低氧血症的严重程度
Rup K Sainju,Deidre N Dragon,Harold B Winnike et al.
Rup K Sainju et al.
Objective: Severe respiratory dysfunction induced by generalized convulsive seizures (GCS) is now thought to be a common mechanism for sudden unexpected death in epilepsy (SUDEP). In a mouse model of seizure-induced death...
Personalized dynamic network models of the human brain as a future tool for planning and optimizing epilepsy therapy [0.03%]
个性化脑动态网络模型作为规划和优化癫痫治疗的未来工具
Isa Dallmer-Zerbe,Premysl Jiruska,Jaroslav Hlinka
Isa Dallmer-Zerbe
Epilepsy is a common neurological disorder, with one third of patients not responding to currently available antiepileptic drugs. The proportion of pharmacoresistant epilepsies has remained unchanged for many decades. To cure epilepsy and c...
Intermittent vs continuous ketogenic diet: Impact on seizures, gut microbiota, and mitochondrial metabolism [0.03%]
间歇性生酮饮食与持续性生酮饮食对癫痫发作、肠道菌群和线粒体代谢的影响比较
Jane Shearer,Morris H Scantlebury,Jong M Rho et al.
Jane Shearer et al.
We have shown previously that the ketogenic diet (KD) is effective in reducing seizures associated with infantile spasms syndrome (ISS) and that this benefit is related to alterations in the gut microbiota. However, it remains unclear wheth...
A concise study of acetazolamide in glucose transporter type 1 deficiency (G1D) epilepsy [0.03%]
乙酰唑胺治疗葡萄糖转运子1缺陷症(G1D)癫痫的初步研究
Ignacio Málaga,Adrian Avila,Sharon Primeaux et al.
Ignacio Málaga et al.
Epilepsy constitutes the most common paroxysmal manifestation of glucose transporter type 1 deficiency (G1D) and is generally considered medication-refractory. It can also prove therapeutic diet-resistant. We examined acetazolamide effects ...