Long-term memory trajectories in seizure-free patients following epilepsy surgery for hippocampal sclerosis [0.03%]
无发作的海马硬化癫痫手术患者的长期记忆轨迹
William Alves Martins,Roberta Gomes,Eduardo Leal-Conceição et al.
William Alves Martins et al.
Objective: This study was undertaken to study long-term memory trajectories over the years in patients with temporal lobe epilepsy and unilateral hippocampal sclerosis (TLE/HS) seizure-free since surgery. ...
Hippocampal abnormality and response to vagus nerve stimulation in epilepsy [0.03%]
迷走神经刺激治疗难治性癫痫的疗效与海马硬化的关联研究
Harry J Clifford,Sonja Fenske,Jonathan Horsley et al.
Harry J Clifford et al.
Vagus nerve stimulation (VNS) reduces seizure frequency and severity in some, but not all, individuals with epilepsy. The hippocampus has been implicated in VNS response, but is yet to be studied structurally using T1-weighted (T1w) magneti...
Motives and predictors of modified Atkins diet discontinuation as treatment of adults with drug-resistant epilepsy [0.03%]
成人难治性癫痫采用改良阿特金斯饮食治疗的停止原因及预测因素分析研究
Raquel Samões,Ana Cavalheiro,Maria Manuel Tavares et al.
Raquel Samões et al.
Objective: This study was undertaken to explore the motives and predictors of modified Atkins diet (MAD) discontinuation as a treatment of adults with drug-resistant epilepsy (DRE). ...
Time to genetic testing in Dravet syndrome: Trends, barriers, and opportunities for improvement [0.03%]
Dravet综合征基因检测的时机：现状、障碍及改善机会
Ross A Carson,John E Maldonado Pacheco,Christina Briscoe Abath et al.
Ross A Carson et al.
Objective: Genetic testing can be necessary in the early diagnosis or confirmation of Dravet syndrome (DS). Despite major advances in availability of genetic testing, several barriers to timely testing persist. These incl...
Haploinsufficiency of brain-specific kinase BRSK1 causes epilepsy and neurodevelopmental disorders [0.03%]
脑特异性激酶BRSK1单倍剂量不足导致癫痫和神经发育障碍
Qi Zhang,Hiroshi Yamanaka,Ping Li et al.
Qi Zhang et al.
Objective: The BRSK1 gene encodes brain-specific serine/threonine kinase 1 (also known as SAD-B kinase), which is almost exclusively expressed in the brain and plays critical roles in neuronal polarization, neurotransmitt...
Selecting effective antiseizure medications for early treatment of SCN8A-related epilepsy using a machine learning approach incorporating clinician and caregiver assessments [0.03%]
利用机器学习方法结合临床医生和护理人员评估选择有效的抗癫痫药物早期治疗SCN8A相关性癫痫
Joshua B Hack,Michael F Hammer
Joshua B Hack
Objective: Despite rapid advances in understanding the disease spectrum and its progression, little is known about which antiseizure medications (ASMs) are likely to be beneficial or detrimental as first-line therapies fo...
Long-term outcomes of stereotactic radiofrequency ablation in hypothalamic hamartomas: A single-center experience [0.03%]
立体射频消融治疗下丘脑错构瘤的长期疗效：单中心经验
Peter Christoph Reinacher,Julia Jacobs,Mukesch Johannes Shah et al.
Peter Christoph Reinacher et al.
Objective: Hypothalamic hamartomas (HHs) lead to refractory epilepsy, and minimally invasive surgical approaches are standard of care for affected patients. Stereotactic radiofrequency thermocoagulation (SRT) is one of th...
Anti-γ-aminobutyric acid B receptor autoimmune encephalitis: Clinical presentation and diagnostic insights [0.03%]
抗γ-氨基丁酸B受体自身免疫性脑炎的临床表现和诊断启示
Naveen K Paramasivan,Jennifer A McCombe,Andrea Stabile et al.
Naveen K Paramasivan et al.
Objectives: γ-Aminobutyric acid B receptor (GABABR)-IgG (immunoglobulin G) is an intermediate-risk paraneoplastic autoantibody often associated with seizures. We aimed to assess the clinical and oncological features of G...
Automated detection of bottom-of-sulcus dysplasia on magnetic resonance imaging-positron emission tomography in patients with drug-resistant focal epilepsy [0.03%]
难治性局灶性癫痫患者磁共振-正电子发射断层扫描影像中半球下沉征的自动化检测方法研究
Emma Macdonald-Laurs,Aaron E L Warren,Remika Mito et al.
Emma Macdonald-Laurs et al.
Objective: Bottom-of-sulcus dysplasia (BOSD) is a diagnostically challenging subtype of focal cortical dysplasia, 60% being missed on magnetic resonance imaging (MRI). Automated MRI-based detection methods have been devel...
Atenolol rescues premature mortality in genetic mouse models of sudden unexpected death in epilepsy [0.03%]
阿替洛尔可救治遗传性癫痫突发意外死亡小鼠模型中的早死现象
Ming S Soh,Amanda Hu,Alibek Kuanyshbek et al.
Ming S Soh et al.
Objective: Sudden unexpected death in epilepsy (SUDEP) is the leading cause of premature mortality in epilepsy. Genetic studies have identified that loss-of-function (LOF) KCNH2 variants are enriched in SUDEP patients, su...