Evaluating multimodal autonomic correlations in pediatric epilepsy using wearable biosignals [0.03%]
基于可穿戴生物信号的小儿癫痫的多模态自主神经关联评价研究
Fatemeh Mohammad Alizadeh Chafjiri,Tanuj Hasija,Emily Peter et al.
Fatemeh Mohammad Alizadeh Chafjiri et al.
Objective: Antiseizure medication (ASM) may affect autonomic nervous system (ANS) activity in patients with epilepsy (PWE). We examined the relationship between ASM dosage and multimodal correlations among ANS signals rec...
Yueyang Liu,Artemio Soto-Breceda,Philippa Karoly et al.
Yueyang Liu et al.
Objective: Forecasting epileptic seizures is a difficult task. Studies of seizure prediction have investigated many different EEG features, but none of them have been useful enough to be applied in clinical practice beyon...
Distinct thalamic functional connectivity and volume patterns across focal epilepsies in children: A multimodal neuroimaging study [0.03%]
儿童局灶性癫痫中丘脑功能连接和体积模式的差异：一项多模态神经影像学研究
Xiyu Feng,Aswin Chari,Maria H Eriksson et al.
Xiyu Feng et al.
Objective: The thalamus is a key hub in seizure propagation, and its nuclei are emerging targets for neuromodulation. However, the contributions of individual nuclei to epileptic networks remain unclear, particularly in c...
Predictive value of seizure onset for gross motor dysfunction in individuals with pathogenic GABRB2 and GABRB3 variants [0.03%]
GABRB2和GABRB3致病变异个体中癫痫发作与粗大运动功能障碍的预测价值
Sebastian Ortiz,Leonardo Affronte,Chiara Bagliani et al.
Sebastian Ortiz et al.
Objective: Pathogenic variants in γ-aminobutyric acid type A (GABAA) receptor genes have been associated with a wide spectrum of neurological disorders. We aimed to delineate the clinical trajectories associated with gai...
Depressive symptoms as independent correlates of epilepsy-related cognitive burden [0.03%]
抑郁症状作为癫痫相关认知负担的独立影响因素
Biagio Maria Sancetta,Giuli Lippa,Marianna Nesta et al.
Biagio Maria Sancetta et al.
Objective: This study was undertaken to assess the relationship between the severity of depression and anxiety symptoms and epilepsy-related variables and cognitive burden in people with epilepsy (PwE), as assessed using ...
Freedon study: Real-life outcomes of cenobamate in different lines of treatment [0.03%]
解密研究：在不同治疗线中司替巴布的真实世界结果
Vicente Villanueva,José María Serratosa,Alejandro Fernández-Cabrera et al.
Vicente Villanueva et al.
Objectives: Cenobamate is an antiseizure medication (ASM) with proven effectiveness in individuals with highly refractory epilepsy. This study investigated the effectiveness and tolerability of cenobamate in different tre...
Inroads into epilepsy through high-frequency oscillations: Achievements and benchmark areas for improvement [0.03%]
通过高频振荡研究癫痫：成就与改进关键领域
Christos Panagiotis Lisgaras,Birgit Frauscher,Jean Gotman et al.
Christos Panagiotis Lisgaras et al.
High-frequency oscillations (HFOs) were discovered more than 20 years ago, and since then they have been studied intensively in the context of epilepsy. HFOs encompass a broad spectrum of oscillations, typically ranging from 80 Hz to severa...
Review
Epilepsia. 2026 Jan 28. DOI:10.1002/epi.70114 2026
Magnetic resonance imaging-negative type II focal cortical dysplasia as a subtle form of bottom-of-sulcus dysplasia: Electrophysiological and histopathological evidence and treatment implications [0.03%]
磁共振成像阴性的局灶性皮质发育不良II型是一种底部半球沟回的皮质发育不良的轻微形式：电生理和组织病理学证据及治疗意义
Weiyuan Luo,Yuan Yuan,Xiangzhi Lu et al.
Weiyuan Luo et al.
Objective: Magnetic resonance imaging (MRI)-negative type II focal cortical dysplasia (FCD) is challenging to localize and treat. Emerging evidence suggests that the sulcal bottom is the critical site of epileptogenicity....
Seizure forecasting with epilepsy cycles: On the causality of forecasting pipelines [0.03%]
基于癫痫周期的发作预测：预测流程因果关系的分析
Hongliu Yang,Jens Müller,Sotirios Kalousios et al.
Hongliu Yang et al.
Objective: Seizure risk is modulated by multiscale brain rhythms. Previous studies using cycles in electroencephalography, heart rate, and wearable data suggest the possibility of forecasting seizures days in advance. How...
Integrated genotype-phenotype function analysis reveals distinct pathogenic mechanisms for cognitive impairment in KCNQ2-related disorders [0.03%]
整合基因型-表型功能分析揭示KCNQ2相关疾病认知障碍的不同致病机制
Juan Xiong,Haolin Duan,Jun Chen et al.
Juan Xiong et al.
Objective: Pathogenic variants of KCNQ2 lead to a spectrum of disorders including self-limited familial neonatal-infantile epilepsy (SeL(F)NIE), developmental and epileptic encephalopathies (DEEs), and neurodevelopmental ...