Franck Toledo
Franck Toledo
Amy Ku,Aaron D Viny
Amy Ku
Neutrophils as chameleons of tissue inflammation and host-pathogen interactions [0.03%]
中性粒细胞在组织炎症和宿主病原体相互作用中的变色龙特性
Yanfang Peipei Zhu,Sergio D Catz,Ben A Croker
Yanfang Peipei Zhu
Neutrophils are acute responders to bacterial and fungal infection; however, their roles in disease extend far beyond their critical roles in countering pathogens. In this review, we seek to provide some broader context based on recent lite...
The CYB5R3 T117S Missense Variant is Associated with Attenuated Riociguat Efficacy in Sickle Cell Disease [0.03%]
CYB5R3 T117S错义变异与镰状细胞病利奥西呱疗效减弱有关
Katherine C Wood,Seyed Mehdi Nouraie,Mark T Gladwin et al.
Katherine C Wood et al.
Sickle cell disease attenuates nitric oxide signaling, limiting soluble guanylyl cyclase (sGC) stimulation needed for hemo-vascular function. Cytochrome b5 reductase 3 (CYB5R3) regulates sGC activity and expression. We show CYB5R3 T117S ass...
Rapid Peak Cilta-cel Expansion is Associated with Delayed Neurotoxicity in Multiple Myeloma [0.03%]
快速达妥昔单抗 blinatumomab 扩散与多发性骨髓瘤延迟神经毒性相关
Hitomi Hosoya,Arash Velayati,Danai Dima et al.
Hitomi Hosoya et al.
The impact of chimeric antigen receptor (CAR)-T cell expansion and persistence on clinical outcomes and treatment-related morbidity in patients with relapsed/refractory multiple myeloma (RRMM) remains incompletely defined, in part due to li...
USP22 is a novel vulnerability regulating MEIS1 protein abundance and gene transcription in KMT2Ar acute leukemia [0.03%]
USP22是调控KMT2A重排急性白血病中MEIS1蛋白丰度和基因转录的新易感位点
Sarah Bröchtel,Constanze Schneider,Marius Müller et al.
Sarah Bröchtel et al.
Patients with acute leukemias harboring translocations involving gene lysine methyltransferase 2A (KMT2A) have a poor prognosis due to chemotherapy resistance with rapid relapse following standard treatments. The resulting KMT2A fusion prot...
Tagraxofusp, Azacitidine, and Venetoclax in Blastic Plasmacytoid Dendritic Cell Neoplasm [0.03%]
Tagraxofusp、阿扎胞苷和维奈克拉治疗颗粒细胞肉瘤
Andrew A Lane,Marlise R Luskin,Julia H Keating et al.
Andrew A Lane et al.
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an orphan, aggressive hematologic malignancy characterized by high CD123 expression. Tagraxofusp (TAG), a CD123-directed toxin, is the only approved therapy. Prior studies demonstrated...
Concurrent administration of BCMA and GPRC5D chimeric antigen receptor (CAR) T cells in advanced multiple myeloma [0.03%]
靶向BCMA和GPRC5D的双CAR-T细胞联合治疗多发性骨髓瘤临床研究
Sham Mailankody,Sneha Mitra,Kevin Herrera et al.
Sham Mailankody et al.
BCMA and GPRC5D-directed therapies have shown high efficacy in the treatment of relapsed or refractory myeloma with multiple new immune therapies now approved. Preclinical studies have shown that expression of BCMA and GPRC5D are heterogeno...