TNFα signaling restores steady-state hematopoiesis in a TNFαKO mouse model of anemia of inflammation [0.03%]
肿瘤坏死因子α信号恢复了肿瘤坏死因子受体1敲除小鼠炎症性贫血稳态造血功能
Amaliris Guerra,Vania Lo Presti,Ding-Wen Chen et al.
Amaliris Guerra et al.
Anemia of inflammation (AI) is the second most common form of anemia and is prevalent in patients with chronic inflammatory states, such as infection, autoimmunity, and cancer. Interleukin 6 (IL6) is well-known to induce the iron-sequesteri...
RhoA GAP Myo9b regulates β2-integrin activity and neutrophil recruitment during murine acute kidney injury [0.03%]
RhoA GAP Myo9b调节β2-整合素活性和小鼠急性肾损伤期间的中性粒细胞募集
Anika Cappenberg,Marina Oguama,Mathis Richter et al.
Anika Cappenberg et al.
An acute inflammatory response to infection or sterile injury involves an adequate activation and recruitment of leukocytes. Activation of β2-integrins is required for neutrophil recruitment and is also mandatory for various neutrophil cel...
A single dose of a CD137 antibody-drug conjugate protects nonhuman primate allogeneic HCT recipients against acute GVHD [0.03%]
单剂量CD137抗体药物偶联物可保护非人灵长类动物同种异体造血细胞移植受者免于急性移植物抗宿主病
Ulrike Gerdemann,Kyle Kimler,Matthew R Warren et al.
Ulrike Gerdemann et al.
Rapid CD137 upregulation on alloreactive T-cells upon allogeneic stimulation suggests that their selective elimination could prevent acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (HCT). Her...
Remission conversion drives outcomes after CAR T-cell therapy for multiple myeloma: a registry analysis from the DRST [0.03%]
CAR-T细胞治疗多发性骨髓瘤后缓解转化驱动预后：来自DRST的注册分析结果
Maximilian Merz,Nico Gagelmann,Samih Smaili et al.
Maximilian Merz et al.
Cellular therapies targeting B-cell maturation antigen have shown promise in controlled clinical trials, but their impact in broader, diverse patient populations remains underexplored. This study examines the real-world efficacy and safety ...
Comparison of the safety profiles of CD19-targeting CAR T-cell therapy in patients with SLE and B-cell lymphoma [0.03%]
比较CAR-T细胞治疗SLE和B细胞淋巴瘤患者的CD19靶向安全特征
Fabian Müller,Nora Rebecca Schwingen,Melanie Hagen et al.
Fabian Müller et al.
CD19-directed chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of relapsed/refractory B-cell non-Hodgkin lymphoma (B-NHL) and recently showed effects in autoimmune diseases such as systemic lupus erythematosus...
Carol Fries
Carol Fries
Pablo Bartolucci
Pablo Bartolucci
Marc Michel
Marc Michel
Daigo Hashimoto
Daigo Hashimoto
R Eric Davis
R Eric Davis