Prognostic impact of variant allele frequency in intensively treated patients with NPM1-mutated AML: a PETHEMA study [0.03%]
NPM1突变型急性髓系白血病强化治疗患者的基因型与预后关联性研究：PETHEMA研究
José Vicente Gil,Claudia Sargas,Rosa Ayala et al.
José Vicente Gil et al.
NPM1-mutated acute myeloid leukemia (AML) is genetically well-defined, but clinical outcomes remain heterogeneous, suggesting that quantitative clonal features may refine current risk stratification. We analyzed 688 intensively treated NPM1...
Targeting the METTL1/m⁷G axis as a therapeutic strategy in myeloid leukemia [0.03%]
靶向METTL1/m⁷G轴作为髓系白血病的治疗策略
Lili Ren,Honghai Zhang,Olga Bobileva et al.
Lili Ren et al.
N7-methylguanosine (m7G), a prevalent modification in tRNAs, is primarily catalyzed by the methyltransferase METTL1. While growing evidence supports a role for METTL1 in various tumors, its therapeutic potential and precise function in leuk...
LCK-targeting molecular glues overcome resistance to inhibitor-based therapy in T-cell acute lymphoblastic leukemia [0.03%]
针对LCK的分子胶克服了T细胞急性淋巴细胞白血病中基于抑制剂的治疗耐药性
Jun J Yang,Satoshi Yoshimura,Marisa Actis et al.
Jun J Yang et al.
Drug resistance is a major challenge in cancer therapy, especially in hematologic malignancies where kinase inhibitors have transformed treatment yet are frequently undermined by drug resistance. While targeted protein degradation (TPD) off...
High-avidity cathepsin-G-specific CAR-T cells for the treatment of acute myeloid leukemia [0.03%]
高亲和力的Cathepsin-G特异性CAR-T细胞在急性髓系白血病治疗中的应用
Gianpietro Dotti,Tara Walhart,Marta Biondi et al.
Gianpietro Dotti et al.
Chimeric antigen receptor (CAR) T cells specific for myeloid-associated antigens expressed on the cell surface of acute myeloid leukemia (AML) can cause depletion of normal myeloid progenitor cells. We developed a CAR specific for a human L...
IRF2 is an Essential Transcription Factor with Pathogenic and Prognostic Impact in Multiple Myeloma [0.03%]
IRF2是多发性骨髓瘤中的一个重要的转录因子，在发病机制及预后中均具有重要作用
Nahia Gómez-Echarte,Arantxa Carrasco-Leon,Alba Maiques-Diaz et al.
Nahia Gómez-Echarte et al.
Multiple Myeloma (MM), the second most prevalent hematologic malignancy, remains incurable, highlighting the need to identify molecular drivers of disease progression and new therapies. Using a CRISPR-Cas9 library screening approach in MM c...
Ralf Küppers
Ralf Küppers
Tom Cupedo
Tom Cupedo
Piers Blombery
Piers Blombery
June Helen Myklebust
June Helen Myklebust
Cédric Duval
Cédric Duval