Measurable Residual Disease-Dependent Unfavorable Outcomes in Pediatric PAX5-Rearranged B-Acute Lymphoblastic Leukemia [0.03%]
PAX5重排型B细胞急性淋巴细胞白血病患儿分子残余病变相关的不良预后
Nicolò Peccatori,Alessia Curto,Daniela Silvestri et al.
Nicolò Peccatori et al.
PAX5-altered acute lymphoblastic leukemia (PAX5-alt ALL) is a recently recognized molecular subtype of B-ALL characterized by a distinct transcriptional signature and frequent PAX5 fusions (PAX5-r). While PAX5-alt ALL has been associated wi...
The hepatic FGFR-ERK-HRG axis regulates heparin-induced thrombocytopenia with thrombosis [0.03%]
肝FGFR-ERK-HRG轴调控肝素诱导的血小板减少症合并血栓形成
Shaoyun Zhou,Tianyu Wang,Miguel A D Neves et al.
Shaoyun Zhou et al.
Heparin-induced thrombocytopenia (HIT) is a life-threatening prothrombotic disorder with substantial clinical mortality, characterized by pathologic antibody formation against platelet factor 4 (PF4)-heparin complexes. This study identified...
HOW I TREAT BLEEDING IN WOMEN AND GIRLS WITH HEMOPHILIA/ HEMOPHILIA CARRIERS [0.03%]
如何治疗血友病女患者及轻链型血友病基因携带者出血问题
Michelle Lavin,Rezan Abdul Kadir Professor,Robert F Sidonio Jr
Michelle Lavin
Historically the impact of hemophilia for female carriers was believed to be restricted to their male offspring. Recent studies have highlighted the increased bleeding experienced by many hemophilia carriers, challenging traditional concept...
FERMT3 alternative splicing enhances kindlin-3 membrane recruitment for neutrophil adhesion during stress myelopoiesis [0.03%]
FERMT3可变剪接增强压力髓样形成过程中的kindlin-3膜募集以促进中性粒细胞粘附
Serena Lee,Gulinare Halimu,Madeleine Sophie Vidal et al.
Serena Lee et al.
Leukocyte Adhesion Deficiency syndrome type III (LAD-III) is characterized by recurrent infections and is caused by FERMT3 gene mutations. FERMT3 encodes two isoforms, a standard kindlin-3 and a longer splicing variant, which differs by the...
Risk of recurrence in patients with provoked venous thromboembolism: a prospective cohort study [0.03%]
对诱发性静脉血栓栓塞症患者的复发风险进行前瞻性队列研究
Sabine Eichinger,Lisbeth Eischer,Alexandra Kaider et al.
Sabine Eichinger et al.
Venous thromboembolism (VTE) provoked by transient risk factors is generally considered low risk, supporting short-term anticoagulation. However, this paradigm is based on heterogeneous definitions of provoking factors. In a prospective coh...
Rebecca K Leaf,David B Sykes
Rebecca K Leaf
Autoimmune neutropenia (AiN) in adults is rare when compared to children. It occurs predominantly in female patients and in individuals with other autoimmune conditions. Anti‑neutrophil antibodies are detected in ~50% of patients with AiN,...
A quantitative definition of the clinical manifestations of GATA2 deficiency in adults [0.03%]
成人GATA2缺陷临床表现的量化定义
Shruthi Mohan,Tilda E Carlelycke,Ashwin Lakshman Koppayi et al.
Shruthi Mohan et al.
Germline GATA2 deficiency is a pleiotropic condition 1-8 characterized by numerous phenotypes, including monocytopenia, immunodeficiency, microbial susceptibilities, and high rates of myeloid malignancies 1,8. Accurate curation of germline ...
Talquetamab in patients with relapsed/refractory multiple myeloma: 3-year follow-up of the phase 1/2 MonumenTAL-1 study [0.03%]
关于复发难治多发性骨髓瘤患者Talquetamab治疗的MonumenTAL-1研究三期随访结果：一项I/II期临床试验
Leo Rasche,Carolina Schinke,Cyrille Touzeau et al.
Leo Rasche et al.
Talquetamab is the first and only approved bispecific antibody targeting G protein-coupled receptor class C group 5 member D (GPRC5D) for treatment of relapsed/refractory multiple myeloma based on results from the phase 1/2 MonumenTAL-1 stu...
Expansion of functional human long-term HSCs through restraining excessive cell cycle activation [0.03%]
通过抑制过度的细胞周期活化扩增功能性的人长期造血干细胞
Xinjian Mao,Ning Zhang,Xi He et al.
Xinjian Mao et al.
Ex vivo expansion of human hematopoietic stem cells (HSCs) holds promise for overcoming their limited availability, a major barrier to broader clinical application. Although recent advances in culture systems can increase HSC numbers, these...
Beat C Bornhauser
Beat C Bornhauser