Anti-αvβ3 antibodies in FNAIT are associated with disturbed angiogenesis and intracranial hemorrhage in men and mice [0.03%]
针对FNAIT的抗αvβ3抗体与男性和小鼠中异常血管生成及颅内出血相关
Yannick Waxmann,Stefanie Jehle,Samir Vaid et al.
Yannick Waxmann et al.
In Caucasians, maternal allo-immunization against human platelet antigen (HPA)-1a is the most common cause for fetal and neonatal alloimmune thrombocytopenia (FNAIT). Intracranial hemorrhage (ICH) is a serious complication. The lack of a co...
Factor VIII Aurora: A Naturally Occurring Gain of Function FVIII Variant with Enhanced FIXa Affinity [0.03%]
第八因子aurora：一种天然存在的von willebrand因子viii获得性功能变异体，具有增强的FIXa亲和力
Johnathan J Morris,Robert J Davidson,Connor T Watson et al.
Johnathan J Morris et al.
Factor VIII Aurora (FVIII-R571S) is the first described naturally occurring enhanced-potency FVIII variant identified in a patient with recurrent thrombosis and early mortality. The patient's plasma exhibited increased procoagulant activity...
Gut Microbiota Drives Aging-related Erythropoiesis Impairment via Phenylacetic Acid-induced Histone Phenylacetylation [0.03%]
肠道微生物组通过苯乙酸诱导的组蛋白苯乙酰化驱动衰老相关红细胞生成障碍
Yifei Xie,Xiangrui Qiao,Hao Wu et al.
Yifei Xie et al.
Anemia, the most prevalent hematologic disorder in older adults, imposes a significant burden of cardiovascular events, cognitive decline, and mortality. However, the mechanisms underlying aging-related anemia, especially epigenetic dysregu...
John W Weisel,Rustem I Litvinov
John W Weisel
Rick Kapur
Rick Kapur
Melissa Zwick,Natalie Köhler
Melissa Zwick
Niels W C J van de Donk,Sonja Zweegman
Niels W C J van de Donk
Catherine Badens,Hélène Guizouarn
Catherine Badens