Uncovering the genetic landscape of cholangiocarcinoma and its subtypes via GWAS and integrative analyses [0.03%]
通过GWAS和综合分析揭示胆管癌及其亚型的遗传景观
Younghun Han,Jinyoung Byun,Caitlin J VanLith et al.
Younghun Han et al.
Background aims: Cholangiocarcinoma (CCA) is a rare but aggressive malignancy with poorly understood genetic susceptibility. To date, genome-wide association studies (GWAS) investigating germline variants associated with ...
Age and sex influence transcriptomic responses to statin therapy that control liver aging during systemic metabolic dysfunction [0.03%]
年龄和性别影响转录组对他汀类药物治疗的反应 以调节全身代谢紊乱情况下的肝衰老
David S Umbaugh,Liuyang Wang,Kuo Du et al.
David S Umbaugh et al.
Background and aims: Older age increases susceptibility to metabolic dysfunction-associated steatotic liver disease (MASLD) but whether it impacts response to therapies, and how the therapies impact regulators of biologic...
Letter to the editor: Hepatocyte-derived extracellular vesicles promote endothelial pyroptosis in chronic liver disease: Undefined role of miR-153-3p [0.03%]
读者来信：肝细胞源性外泌体通过促进内皮细胞焦亡介导慢性肝脏疾病：miR-153-3p的作用未明
Xinyi Hu,Qi Zhang,Lulu Wan et al.
Xinyi Hu et al.
Association between statin use and hepatic decompensation in patients with primary biliary cholangitis: A target trial emulation study [0.03%]
他汀类药物使用与原发性胆汁性胆管炎患者肝失代偿的相关性：靶向试验仿真研究
Jonggi Choi,Junqing Xu,Vy H Nguyen et al.
Jonggi Choi et al.
Background and aims: Statins have been investigated for their potential to reduce liver-related complications in chronic liver diseases, but evidence in primary biliary cholangitis (PBC) remains limited. This study aimed ...
Incorporating artificial intelligence into imaging for surveillance and diagnosis of liver cancer: Innovations, challenges, and clinical translation [0.03%]
人工智能在肝癌监测和诊断成像中的应用：创新、挑战及临床转化
Maxime Ronot,Julien Calderado
Maxime Ronot
Primary liver cancer, mainly hepatocellular carcinoma and intrahepatic cholangiocarcinoma, remains a leading cause of cancer mortality worldwide. Early detection is crucial for curative treatment, yet current surveillance and diagnostic str...
Impact of newer antihyperglycemic agents on hepatic complications: A systematic review and meta-analysis of data from 5.3 million patients with type 2 diabetes mellitus [0.03%]
新型降糖药物对肝脏并发症影响的系统评价和荟萃分析：来源于530万例2型糖尿病患者的证据
Jiwon Yang,Yeongseok Hwang,Jin-Sung Ju et al.
Jiwon Yang et al.
Background aims: Type 2 diabetes mellitus (T2DM) is a recognized modifiable risk factor for hepatocellular carcinoma (HCC) and liver-related mortality. The effects of newer antidiabetic agents-including glucagon-like pept...
Letter to the editor: Deep learning and digital pathology for HCC prediction in steatotic liver disease [0.03%]
读者来信：用于脂肪性肝病中肝癌预测的深度学习与数字病理学
Luisa Giudice,Stefano Granieri,Stefania Galassi et al.
Luisa Giudice et al.
Reply: From weight to waist: Refining fibrosis prediction in the global MASLD cohort [0.03%]
关于从体重到腰围：在全世界MASLD队列中精炼纤维化预测的来信答复
Maria Stepanova,Zobair M Younossi
Maria Stepanova
Genomic and transcriptomic profiling of hepatocellular carcinoma in patients with Fontan-associated liver disease [0.03%]
与Fontan肝病患者肝细胞癌的基因组和转录组谱分析
Taiji Yamazoe,Eiji Kakazu,Michitaka Matsuda et al.
Taiji Yamazoe et al.
Background aims: Fontan-associated liver disease (FALD) could lead to liver cirrhosis and hepatocellular carcinoma (HCC). The prognosis of FALD patients is worse when HCC develops. Therefore, better understanding of the m...