Gfi1-Cre knock-in mouse line: A tool for inner ear hair cell-specific gene deletion [0.03%]
Gfi1-Cre敲入小鼠品系：内耳毛细胞特异性基因删除工具
Hua Yang,Jean Gan,Xiaoling Xie et al.
Hua Yang et al.
Gfi1 encodes a zinc-finger transcription factor essential for the development and maintenance of haematopoiesis and the inner ear. In mouse inner ear, Gfi1 expression is confined to hair cells during development and in adulthood. To constru...
A Tlx2-Cre mouse line uncovers essential roles for hand1 in extraembryonic and lateral mesoderm [0.03%]
一个Tlx2-Cre小鼠品系揭示了Hand1在额外胚胎和侧中胚层中的重要作用
Emily L Maska,Peter Cserjesi,Lisa L Hua et al.
Emily L Maska et al.
Hand1 regulates development of numerous tissues within the embryo, extraembryonic mesoderm, and trophectoderm. Systemic loss of Hand1 results in early embryonic lethality but the cause has remained unknown. To determine if Hand1 expression ...
An improved Flp deleter mouse in C57Bl/6 based on Flpo recombinase [0.03%]
基于Flpo重组酶的C57Bl/6背景改进型Flp删减小鼠
Andrea Kranz,Jun Fu,Kristin Duerschke et al.
Andrea Kranz et al.
Recently, a codon improved version of the Flpe site specific recombinase, termed Flpo, was reported as having greatly improved performance in mammalian cell applications. However, the degree of improvement could not be estimated because ess...
A functional NR4A nuclear receptor DNA-binding domain is required for organ development in Caenorhabditis elegans [0.03%]
NR4A核受体的DNA结合域对秀丽隐杆线虫器官发育是必需的
Melissa Heard,Claude V Maina,Benjamin E Morehead et al.
Melissa Heard et al.
NR4A nuclear receptors are a diverse group of orphan nuclear receptors with critical roles in regulating cell proliferation and cell differentiation. The ortholog of the NR4A nuclear receptor in Caenorhabditis elegans, NHR-6, also has a rol...
Characterization of bacterial artificial chromosome transgenic mice expressing mCherry fluorescent protein substituted for the murine smooth muscle alpha-actin gene [0.03%]
mCherry荧光蛋白取代的小鼠平滑肌α肌动蛋白基因的细菌人工染色体转基因小鼠的表征
John J Armstrong,Irina V Larina,Mary E Dickinson et al.
John J Armstrong et al.
Smooth muscle alpha actin (SMA) is a cytoskeletal protein expressed by mesenchymal and smooth muscle cell types, including mural cells (vascular smooth muscle cells and pericytes). Using Bacterial Artificial Chromosome (BAC) recombineering ...
Development and function of central cell in angiosperm female gametophyte [0.03%]
被子植物雌配子体中央细胞的发育与功能
Yan Liu,Zhiqiang Yan,Ni Chen et al.
Yan Liu et al.
The central cell characterizes the angiosperm female gametophyte (embryo sac or megagametophyte) in that it directly participates in "double fertilization" to initiate endosperm development, a feature distinguishing angiosperm from all othe...
Kinesin II is required for cell survival and adherens junction positioning in Drosophila photoreceptors [0.03%]
果蝇视杆细胞中动力蛋白II型微管 motor蛋白是维持细胞存活和粘着带定位的必要条件
Bibhash Mukhopadhyay,Sang-Chul Nam,Kwang-Wook Choi
Bibhash Mukhopadhyay
Photoreceptor morphogenesis requires specific and coordinated localization of junctional markers at different stages of development. Here, we provide evidence that Drosophila Klp64D, a homolog of Kif3A motor subunit of the heterotrimeric Ki...
Zebrafish sp7:EGFP: a transgenic for studying otic vesicle formation, skeletogenesis, and bone regeneration [0.03%]
斑马鱼sp7:egfp转基因系：用于研究耳囊形成、骨发育和骨再生
April DeLaurier,B Frank Eames,Bernardo Blanco-Sánchez et al.
April DeLaurier et al.
We report the expression pattern and construction of a transgenic zebrafish line for a transcription factor involved in otic vesicle formation and skeletogenesis. The zinc finger transcription factor sp7 (formerly called osterix) is reporte...
Vectors for efficient and high-throughput construction of fluorescent drosophila reporters using the PhiC31 site-specific integration system [0.03%]
用于荧光果蝇报告基因高通量高效构建的PhiC31特异性整合系统供体质粒
Aurelia L Boy,Zongzhao Zhai,Anette Habring-Müller et al.
Aurelia L Boy et al.
The fruit fly Drosophila is a leading model system for the study of transcriptional control by cis-regulatory elements or enhancers. Here, we present a rapid and highly efficient system for the large-scale analysis of enhancer elements, sit...
Generation of a mouse line expressing Cre recombinase in glycinergic interneurons [0.03%]
生成在甘氨酸能中间神经元中表达Cre重组酶的小鼠品系
Naoko Ishihara,Wencke Armsen,Theofilos Papadopoulos et al.
Naoko Ishihara et al.
In caudal regions of the CNS, glycine constitutes the major inhibitory neurotransmitter. Here, we describe a mouse line that expresses Cre recombinase under the control of a BAC transgenic glycine transporter 2 (GlyT2) promoter fragment. Ma...