Marie L Nydam,Devon Gamble,Tal Gordon et al.
Marie L Nydam et al.
Generation of Knock-In Syrian Hamsters via Zygote Microinjection Using CRISPR/Cas9 Genome Editing [0.03%]
基于CRISPR/Cas9基因编辑的仓鼠受精卵显微注射敲入技术
Mayo Shigeta,Ken-Ichi Inoue,Naoko Shimada et al.
Mayo Shigeta et al.
Syrian hamsters (Mesocricetus auratus) have long served as valuable model organisms in diverse research fields such as oncology, immunology, and physiology owing to their unique biological and pathological characteristics. Although embryo m...
Generation of Astrocyte-Selective Cre Driver Lines With Distinct Onsets of Recombination Activity During Development [0.03%]
具有不同发育时期重组活性的星形胶质细胞谱系选择性Cre驱动品系的建立
Yukina Izumi,Tomoya Nakatani,Harumi Takai et al.
Yukina Izumi et al.
Astrocytes are a major glial cell type, playing multiple roles in the development, function, and pathogenesis of the brain. Accordingly, neuronal-astrocyte communication is an important research area. However, because these cell types share...
A Cxcl15 Cre Recombinase Mouse Model Useful to Study Gland Development in the Uterus [0.03%]
一种可用于研究子宫腺体发育的Cxcl15 Cre重组酶小鼠模型
Andrew M Kelleher,Hong Im Kim,Greeshma Sai Bayammagari et al.
Andrew M Kelleher et al.
The mammalian uterus contains glands in the endometrium that develop only or primarily after birth. In the mouse, endometrial glands govern post implantation pregnancy establishment via regulation of blastocyst implantation, stromal cell de...
Expression Patterns of sfrp Genes During Regeneration in the Holothurian Eupentacta fraudatrix [0.03%]
Eupentacta fraudatrix 海参再生过程中sfrp基因的表达模式研究
Konstantin Sadriev
Konstantin Sadriev
Secreted Frizzled-related proteins (SFRPs) are a small, ancient family of extracellular signaling pathway agonists and antagonists. In this study, we examined their expression patterns during regeneration in the holothurian Eupentacta fraud...
Current Perspectives on Mesenchymal Stem Cells as a Potential Treatment for Periodontal Diseases and Conditions [0.03%]
有关间充质干细胞作为牙周病和条件潜在治疗的当前观点
Shuyu Cai,Cong Li,Biaowen Wei et al.
Shuyu Cai et al.
Periodontal diseases, including periodontitis and gingivitis, constitute a major global health burden, affecting over 1 billion people worldwide. These conditions typically initiate in adulthood and progress chronically, often exhibiting se...
Development of a Hepatocyte-Specific Temporal Genetic Mouse Model Using Albumin Promoter-Driven FlpER2 Expression [0.03%]
利用白蛋白启动子驱动的FlpER2表达建立肝细胞特异性时空遗传小鼠模型
Bin Wang,Jiale Wang,Yang Liu et al.
Bin Wang et al.
Tissue-specific gene manipulation using Cre/loxP or Flp/frt recombination systems is a cornerstone of genetically engineered mouse models. In this study, we aim to develop a novel hepatocyte-specific, tamoxifen-inducible Flp mouse line. BAC...
Tracing Early Migratory Neurons in the Developing Nose Using Contactin-2 (Cntn2) CreERT2 [0.03%]
利用Contactin-2 (Cntn2) CreERT2追踪发育中鼻部的早期迁徙神经元
Enrico Amato Jr,Alexis M Semon,Paolo E Forni
Enrico Amato Jr
Neuronal migration during embryonic development is a fundamental process. In the developing nose of rodents, neurons that form during early neurogenic waves in the olfactory placode leave this structure to migrate toward or into the develop...
Identification and Classification of Zinc Finger Proteins Encoded in the Genome of an Ascidian [0.03%]
刺 ascidians 基因组中锌指蛋白的鉴定与分类
Natsuko Tamura,Yutaka Satou
Natsuko Tamura
Genes encoding C2H2-type zinc finger (ZF) proteins constitute one of the largest gene families in animal genomes. Many C2H2-type ZF domains are used for DNA-binding, and others are used for protein-protein interactions and RNA-binding. In a...
Generation of Plexin-B1 Conditional Knockout Mouse With CRISPR/Cas9 Technology [0.03%]
CRISPR/Cas9技术生成Plexin-B1条件性敲除小鼠
Haofei Ni,Kevin Kelley,Ning Xie et al.
Haofei Ni et al.
Plexins are axon guidance transmembrane receptors that control cytoskeleton and membrane dynamics in development and adult physiology. As plexins are expressed in multiple cell types in various tissues, floxed alleles that enable conditiona...