prdm1a Regulates sox10 and islet1 in the development of neural crest and Rohon-Beard sensory neurons [0.03%]
PRDM1A在神经嵴和罗汉贝德感觉神经元发育中调节SOX10和ISL1表达中的作用
Eugenia Olesnicky,Laura Hernandez-Lagunas,Kristin Bruk Artinger
Eugenia Olesnicky
The PR domain containing 1a, with ZNF domain factor, gene (prdm1a) plays an integral role in the development of a number of different cell types during vertebrate embryogenesis, including neural crest cells, Rohon-Beard (RB) sensory neurons...
Msx1 and Dlx5 function synergistically to regulate frontal bone development [0.03%]
MSX1和DLX5协同调节额骨发育
Il-Hyuk Chung,Jun Han,Junichi Iwata et al.
Il-Hyuk Chung et al.
The Msx and Dlx families of homeobox proteins are important regulators for embryogenesis. Loss of Msx1 in mice results in multiple developmental defects including craniofacial malformations. Although Dlx5 is widely expressed during embryoni...
Brain expression of Cre recombinase driven by pancreas-specific promoters [0.03%]
由胰腺特异性启动子驱动的脑部Cre重组酶表达
Junghun Song,Yuanzhong Xu,Xiaoxia Hu et al.
Junghun Song et al.
Cre-loxP technology enables specific examination of the function and development of individual nuclei in the complex brain network. However, for most brain regions, the utilization of this technique has been hindered by the lack of mouse li...
A Cre transgenic line for studying V2 neuronal lineages and functions in the spinal cord [0.03%]
一个用于研究脊髓中V2神经元谱系和功能的Cre转基因品系
Shengguo Li,Kamana Misra,Mengqing Xiang
Shengguo Li
During spinal neurogenesis, the p2 progenitor domain generates at least two subclasses of interneurons named V2a and V2b, which are components of the locomotor central pattern generator. The winged-helix/forkhead transcription factor Foxn4 ...
Sox9-expressing precursors are the cellular origin of the cruciate ligament of the knee joint and the limb tendons [0.03%]
SOX9阳性细胞是膝关节十字韧带和四肢肌腱的起源细胞
Tsunemitsu Soeda,Jian Min Deng,Benoit de Crombrugghe et al.
Tsunemitsu Soeda et al.
Sox9 expression defines cell progenitors in a variety of tissues during mouse embryogenesis. To establish a genetic tool for cell-lineage tracing and gene-function analysis, we generated mice in which the CreERT2 gene was targeted to the en...
Highlighted article: "Focal adhesion kinase is essential for cardiac looping and multi-chamber heart formation" by Doherty, Conlon, Mack, and Taylor [0.03%]
亮点文章：“Focal adhesion kinase is essential for cardiac looping and multi-chamber heart formation"(亮点评述：焦点粘附激酶对心脏卷曲及多心室形成至关重要)作者：Doherty，Conlon，Mack和Taylor
Beatrice Grabner,Leander Blaas,Monica Musteanu et al.
Beatrice Grabner et al.
Here we describe the generation of an inducible Cre transgenic line allowing conditional mutagenesis in ovarian granulosa cells. We have expressed the tamoxifen inducible CreER(T)² fusion protein from a Bacterial Artificial Chromosome (BAC...
Comparative Study
Genesis (New York, N.Y. : 2000). 2010 Oct 1;48(10):612-7. DOI:10.1002/dvg.20664 2010
Antonia Sassmann,Stefan Offermanns,Nina Wettschureck
Antonia Sassmann
To generate a mouse line which allows inducible, Cre/loxP-dependent recombination in adipocytes, we used RedE/RedT-mediated recombineering to insert the CreER(T)²-transgene, which encodes a fusion protein of Cre and a mutated tamoxifen-res...
Comparative Study
Genesis (New York, N.Y. : 2000). 2010 Oct 1;48(10):618-25. DOI:10.1002/dvg.20665 2010
RU486-inducible recombination in the salivary glands of lactoferrin promoter-driven green fluorescent Cre transgenic mice [0.03%]
由乳铁蛋白启动子驱动的绿色荧光Cre转基因小鼠的重组唾液腺中的RU486诱导型重组反应
Mei-Ru Chen,Shan-Wen Liu,Tzu-Chin Wu et al.
Mei-Ru Chen et al.
When compared with the many tamoxifen-activated Cre mouse lines available for gene manipulation studies, relatively few RU486-inducible Cre mice are in use, due to leakiness issues. Here, we report the generation of an RU486-inducible tripl...
A novel null allele of mouse DSCAM survives to adulthood on an inbred C3H background with reduced phenotypic variability [0.03%]
一个新的Dscam突变小鼠品系的建立及表型分析
Peter G Fuerst,Belinda S Harris,Kenneth R Johnson et al.
Peter G Fuerst et al.
DSCAMs are cell adhesion molecules that play several important roles in neurodevelopment. Mouse alleles of Dscam identified to date do not survive on an inbred C57BL/6 background, complicating analysis of DSCAM-dependent developmental proce...