Taste bud cells of adult mice are responsive to Wnt/β-catenin signaling: implications for the renewal of mature taste cells [0.03%]
味觉细胞的更新与Wnt/β-连锁素信号转导的关系
Dany Gaillard,Linda A Barlow
Dany Gaillard
Wnt/β-catenin signaling initiates taste papilla development in mouse embryos, however, its involvement in taste cell turnover in adult mice has not been explored. Here we used the BATGAL reporter mouse model, which carries an engineered al...
Direct examination of chromosomal clustering of organ-specific genes in the chordate Ciona intestinalis [0.03%]
直接检测有机特异性基因在脊索动物雪旺氏菌染色体上聚类的情况
Eiichi Shoguchi,Mayuko Hamada,Manabu Fujie et al.
Eiichi Shoguchi et al.
One of challenges in the field of developmental biology is to understand how spatially and/or temporally coordinated expression of genes is controlled at the chromosomal level. It remains controversial whether genes expressed in a given tis...
A mart-1::Cre transgenic line induces recombination in melanocytes and retinal pigment epithelium [0.03%]
一种mart-1::cre转基因品系在黑色素细胞和视网膜色素上皮中引起重组事件
Iraz T Aydin,Friedrich Beermann
Iraz T Aydin
The number of transgenic mouse lines expressing Cre in either type of pigment cells (melanocytes and retinal pigment epithelium, RPE) is limited, and the available lines do not always offer sufficient specificity. In this study, we addresse...
Pax6 regulates craniofacial form through its control of an essential cephalic ectodermal patterning center [0.03%]
Pax6通过调控头面部关键模式中心的形成来控制颅面发育形状和大小
Claudia Compagnucci,Jennifer L Fish,Manuela Schwark et al.
Claudia Compagnucci et al.
Normal patterning and morphogenesis of the complex skeletal structures of the skull requires an exquisite, reciprocal cross-talk between the embryonic cephalic epithelia and mesenchyme. The mesenchyme associated with the jaws and the optic ...
Rho signaling pathway and apical constriction in the early lens placode [0.03%]
ρ信号通路和早期晶状体原基顶侧收缩的作用机制
Ricardo Moraes Borges,Marcelo Lazzaron Lamers,Fabio Luis Forti et al.
Ricardo Moraes Borges et al.
Epithelial invagination in many model systems is driven by apical cell constriction, mediated by actin and myosin II contraction regulated by GTPase activity. Here we investigate apical constriction during chick lens placode invagination. I...
Stephen A Murray
Stephen A Murray
The mouse, as a genetically defined and easily manipulated model organism, has played a critical role in unraveling the mechanisms of craniofacial development and dysmorphology. While numerous gene knockout strains that display craniofacial...
Reptilian tooth development [0.03%]
爬行动物牙齿的发育
Joy M Richman,Gregory R Handrigan
Joy M Richman
Dental patterns in vertebrates range from absence of teeth to multiple sets of teeth that are replaced throughout life. Despite this great variation, most of our understanding of tooth development is derived from studies on just a few model...
Lucie Jeannotte,Josée Aubin,Sylvie Bourque et al.
Lucie Jeannotte et al.
Cre-expressing mouse lines constitute an important asset to mammalian genetics, allowing the deletion of genes in a spatio-temporal specific manner. Our study on Hox gene function in lung development has led us to use a lung endoderm-specif...
Generation of two modified mouse alleles of the Hic1 tumor suppressor gene [0.03%]
两种修改型小鼠Hic1抑癌基因等位基因的构建
Vendula Pospichalova,Jolana Tureckova,Bohumil Fafilek et al.
Vendula Pospichalova et al.
HIC1 (hypermethylated in cancer 1) is a tumor suppressor gene located on chromosome 17p13.3, a region frequently hypermethylated or deleted in human neoplasias. In mouse, Hic1 is essential for embryonic development and exerts an antitumor r...
Generation and characterization of iUBC-KikGR photoconvertible transgenic mice for live time-lapse imaging during development [0.03%]
一种用于发育过程中活体延时成像的iUBC-KikGR光转换转基因小鼠的构建与鉴定
Shannon L Griswold,Krishna C Sajja,Chuan-Wei Jang et al.
Shannon L Griswold et al.
A transgenic mouse line named iUBC-KikGR was generated, which expresses the photoconvertible fluorescent protein Kikume Green-Red (KikGR) under the control of the human Ubiquitin C promoter. KikGR is natively a green fluorophore, which can ...