Ralph S Marcucio,Nathan M Young,Diane Hu et al.
Ralph S Marcucio et al.
The effect of the brain on the morphology of the face has long been recognized in both evolutionary biology and clinical medicine. In this work, we describe factors that are active between the development of the brain and face and how these...
Tong Li,Ming-Szu Hung,Yucheng Wang et al.
Tong Li et al.
The Cullin 4A(Cul4A) gene is important in cell survival, development, growth, and cell cycle control and is amplified in breast and hepatocellular cancers. Recently, we reported that Cul4A plays an oncogenic role in the pathogenesis of meso...
Molecular analysis of neurogenic placode development in a basal ray-finned fish [0.03%]
硬骨鱼神经源性胎板发育的分子分析
Melinda S Modrell,David Buckley,Clare V H Baker
Melinda S Modrell
Neurogenic placodes are transient, thickened patches of embryonic vertebrate head ectoderm that give rise to the paired peripheral sense organs and most neurons in cranial sensory ganglia. We present the first analysis of gene expression du...
Rachel Fink
Rachel Fink
In the mid-1980s live-cell imaging was changed by the introduction of video techniques, allowing new ways to collect and store data. The increased resolution obtained by manipulating video signals, the ability to use time-lapse videocassett...
Rong Xie,Rulang Jiang,Di Chen
Rong Xie
Axin1 is a critical negative regulator of the canonical Wnt-signaling pathway. It is a concentration-limiting factor in the β-catenin degradation complex. Axin1 null mutant mouse embryos died at embryonic day 9.5, precluding direct genetic...
One-step knockin for inducible expression in mouse embryonic stem cells [0.03%]
用于小鼠胚胎干细胞的可诱导表达的一步法基因敲入技术
Yong Jun Choi,Mi Young Son,Paul Hasty
Yong Jun Choi
Transgenesis enables the elucidation of gene function; however, constant transgene expression is not always desired. The tetracycline responsive system was devised to turn on and off transgene expression at will. It has two components: a do...
Inducible Cx40-Cre expression in the cardiac conduction system and arterial endothelial cells [0.03%]
心脏传导系统和动脉内皮细胞中Cx40-Cre的诱导型表达
Sabrina Beyer,Robert G Kelly,Lucile Miquerol
Sabrina Beyer
The Connexin-40 (Cx40) gene encodes a gap junction protein that plays an important role in cell-cell communication in cardiomyocytes of the atria and cardiac conduction system and endothelial cells of large arteries. During embryonic develo...
Regulated expression of transgenes in embryonic stem cell-derived neural cells [0.03%]
胚胎干细胞来源的神经细胞中转基因的表达调控
David S Lorberbaum,David Gottlieb
David S Lorberbaum
Discovery and characterization of gene promoters, enhancers and repressor binding elements is an important research area in neuroscience. Here, the suitability of embryonic stem cells and their neural derivatives as a model system for this ...
Generation and characterization of Col10a1-mcherry reporter mice [0.03%]
胶原蛋白Col10a1-mcherry报告基因小鼠的构建及鉴定
Peter Maye,Yu Fu,David L Butler et al.
Peter Maye et al.
We report here on the generation of a new fluorescent protein reporter transgenic mouse line, Col10a1-mCherry, which can be used as a tool to study chondrocyte biology and pathology. Collagen, Type X, alpha 1 (Col10a1) is highly expressed i...
Podosomal proteins as causes of human syndromes: a role in craniofacial development? [0.03%]
胞质骨架蛋白作为人类综合征的致病因素？其在颅面发育中的作用？
Pilar Cejudo-Martin,Sara A Courtneidge
Pilar Cejudo-Martin
Podosomes and invadopodia are actin-rich protrusions of the plasma membrane important for matrix degradation and cell migration. Most of the information in this field has been obtained in cancer cells, where the presence of invadopodia has ...