Characterization of Pdgfrb-Cre transgenic mice reveals reduction of ROSA26 reporter activity in remodeling arteries [0.03%]
Pdgfrb-Cre转基因小鼠的特征表明ROSAS26报告基因活性在动脉重塑过程中的降低
Anne S Cuttler,Renée J LeClair,J Patrizia Stohn et al.
Anne S Cuttler et al.
With the intention to modulate gene expression in vascular mural cells of remodeling vessels, we generated and characterized transgenic mouse lines with Cre recombinase under the control of the platelet-derived growth factor receptor-β pro...
Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling [0.03%]
印度刺猬基因正向调节颅骨骨化并调控骨形态发生蛋白信号通路
Kelly Lenton,Aaron W James,Alina Manu et al.
Kelly Lenton et al.
Much is known regarding the role of Indian hedgehog (Ihh) in endochondral ossification, where Ihh regulates multiple steps of chondrocyte differentiation. The Ihh-/- phenotype is most notable for severely foreshortened limbs and a complete ...
Zebrafish heat shock protein a4 genes in the intestinal epithelium are up-regulated during inflammation [0.03%]
热休克在肠道上皮中的作用 механизмы действия熱應激蛋白a4基因在斑馬魚腸道上皮中炎症時の誘導
Katie C Crawford,Maria Vega Flores,Stefan H Oehlers et al.
Katie C Crawford et al.
A number of heat shock proteins (HSPs), including Hsp70 and Hsp110, function as molecular chaperones within intestinal epithelial cells that line the mammalian digestive system. HSPs confer cellular protection against environmental stress i...
In vivo labeling of zebrafish motor neurons using an mnx1 enhancer and Gal4/UAS [0.03%]
斑马鱼运动神经元的体内标记：利用mnx1增强子和Gal4/UAS系统
Taras A Zelenchuk,Juan L Brusés
Taras A Zelenchuk
The zebrafish spinal cord primary motor neurons are commonly used as an experimental model to study the molecular mechanisms that regulate axonal pathfinding and neuromuscular junction formation, and for the modeling of human neurodegenerat...
An inducible transgenic Cre mouse line for the study of hippocampal development and adult neurogenesis [0.03%]
一个用于海马发育和成人神经发生的可诱导的转基因Cre小鼠品系
Yiping Li,Chuanxi Tian,Ying Yang et al.
Yiping Li et al.
The hippocampus is crucial for higher brain functions, such as learning, memory, and emotion. Many diseases like epilepsy and Down's syndrome are associated with abnormalities in early hippocampal development. In addition, adult dentate neu...
Uncoupling of retinoic acid signaling from tailbud development before termination of body axis extension [0.03%]
视黄酸信号与尾芽发育在躯体轴延长终止前的解偶联现象
Thomas J Cunningham,Xianling Zhao,Gregg Duester
Thomas J Cunningham
During the early stages of body axis extension, retinoic acid (RA) synthesized in somites by Raldh2 represses caudal fibroblast growth factor (FGF) signaling to limit the tailbud progenitor zone. Excessive RA down-regulates Fgf8 and trigger...
Generation of a tamoxifen inducible SMN mouse for temporal SMN replacement [0.03%]
用于在特定时间替换SMN蛋白而生成的他莫西芬诱导型SMN小鼠
Thomas W Bebee,Jordan T Gladman,Dawn S Chandler
Thomas W Bebee
Proximal spinal muscular atrophy (SMA) is caused by low levels of the SMN protein, encoded by the Survival Motor Neuron genes (SMN1 and SMN2). Mouse models of SMA can be rescued by increased SMN expression, but the timing of SMN replacement...
Dirk Wenzel,Francesca Palladino,Monika Jedrusik-Bode
Dirk Wenzel
Epigenetics is defined as the study of heritable changes in gene expression that are not accompanied by changes in the DNA sequence. Epigenetic mechanisms include histone post-translational modifications, histone variant incorporation, non-...
Laura W Gamer,Kunikazu Tsuji,Karen Cox et al.
Laura W Gamer et al.
Initiation of BMP signaling is dependent upon activation of Type I BMP receptor by constitutively active Type II BMP receptor. Three Type II BMP receptors have been identified; Acvr2a and Acvr2b serve as receptors for BMPs and for activin-l...