Zebrafish Tshz3b negatively regulates Hox function in the developing hindbrain [0.03%]
视黄酸在斑马鱼后脑发育中负调控Tshz3b基因表达的作用
Timothy Erickson,Laura M Pillay,Andrew J Waskiewicz
Timothy Erickson
In flies, the zinc-finger protein Teashirt promotes trunk segmental identities, in part, by repressing the expression and function of anterior hox paralog group (PG) 1-4 genes that specify head fates. Anterior-posterior patterning of the ve...
Early oogenesis in the short-tailed fruit bat Carollia perspicillata: transient germ cell cysts and noncanonical intercellular bridges [0.03%]
短尾果蝠Carollia perspicillata早期卵发生过程中的瞬时生殖细胞囊和非经典细胞间桥
Agnieszka Lechowska,Szczepan M Bilinski,John J Rasweiler th et al.
Agnieszka Lechowska et al.
The ovaries of early embryos (40 days post coitum/p.c.) of the bat Carollia perspicillata contain numerous germ-line cysts, which are composed of 10 to 12 sister germ cells (cystocytes). Variability in the number of cystocytes within the cy...
Comparative Study
Genesis (New York, N.Y. : 2000). 2012 Jan;50(1):18-27. DOI:10.1002/dvg.20780 2012
Position matters: variability in the spatial pattern of BMP modulators generates functional diversity [0.03%]
位置决定作用：BMP调节点阵模式的可变性决定了其功能多样性
Helena Araujo,Marcio Ribeiro Fontenele,Rodrigo Nunes da Fonseca
Helena Araujo
Bone morphogenetic proteins (BMPs) perform a variety of functions during development. Considering a single BMP, what enables its multiple roles in tissues of varied sizes and shapes? What regulates the spatial distribution and activity patt...
Efficient inducible Pan-neuronal cre-mediated recombination in SLICK-H transgenic mice [0.03%]
SLICK-H小鼠高效可诱导的泛神经元cre重组事件
Victoria Heimer-McGinn,Paul Young
Victoria Heimer-McGinn
Large-scale functional genomics in mice is becoming feasible through projects to develop conditional knockout alleles for every gene. Inducible neuron-specific gene knockout in such mice will permit the analysis of neuronal phenotypes while...
Jungho Ohn,Jennifer Yang,Scott E Fraser et al.
Jungho Ohn et al.
Images of multiply labeled fluorescent samples provide unique insights into the localization of molecules, cells, and tissues. The ability to image multiple channels simultaneously at high speed without cross talk is limited to a few colors...
Generation of the tamoxifen-inducible DBH-Cre transgenic mouse line DBH-CT [0.03%]
生成雌激素受体诱导型多巴胺β羟化酶-DNA转移酶小鼠品系DBH-CT
Jutta Stubbusch,Afsaneh Majdazari,Mirko Schmidt et al.
Jutta Stubbusch et al.
We generated transgenic mice bearing a tamoxifen-dependent Cre recombinase expressed under the control of the dopamine-β-hydroxylase promoter. By crossing to the ROSA26 reporter mice we show that tamoxifen-induced Cre recombinase in adult ...
Production of offspring from cloned transgenic RFP female dogs and stable generational transmission of the RFP gene [0.03%]
克隆转基因红色荧光蛋白雌性狗的繁殖及其红系荧光蛋白基因的稳定传递
So Gun Hong,Hyun Ju Oh,Jung Eun Park et al.
So Gun Hong et al.
The purpose of this study was to analyze the reproductive ability of transgenic female dogs born bysomatic cell nuclear transfer and to determine inheritance of the red fluorescent protein (RFP) transgene. The four founder transgenic bitche...
Generation of transgenic dogs that conditionally express green fluorescent protein [0.03%]
生成条件表达绿色荧光蛋白的转基因狗
Min Jung Kim,Hyun Ju Oh,Jung Eun Park et al.
Min Jung Kim et al.
We report the creation of a transgenic dog that conditionally expresses eGFP (enhanced green fluorescent protein) under the regulation of doxycycline. Briefly, fetal fibroblasts infected with a Tet-on eGFP vector were used for somatic cell ...
Synphilin suppresses α-synuclein neurotoxicity in a Parkinson's disease Drosophila model [0.03%]
帕金森病果蝇模型中Synphilin通过抑制α-突触核蛋白神经毒性作用发挥作用
René Hernández-Vargas,Luis Fonseca-Ornelas,Ignacio López-González et al.
René Hernández-Vargas et al.
Parkinson's disease (PD) is the second most common neurodegenerative disorder in humans. It affects 1% of the population over 65-years old. Its causes are environmental and genetic. As the world population ages, there is an urgent need for ...