DNApol-ϵ gene is indispensable for the survival and growth of Drosophila melanogaster [0.03%]
果蝇DNApol-ϵ基因对其生存和生长是必不可少的
Akanksha Verma,Sonali Sengupta,Subhash C Lakhotia
Akanksha Verma
Based on deletion and complementation mapping and DNA sequencing, a new recessive fully penetrant mutation (DNApol-ϵpl10R), causing prolonged larval life and larval/early pupal lethality, is identified as the first mutant allele of the DNA...
Transcriptional regulation of eater gene expression in Drosophila blood cells [0.03%]
果蝇血细胞中Eater基因表达的转录调控机制研究
Paul T Kroeger Jr,Tsuyoshi Tokusumi,Robert A Schulz
Paul T Kroeger Jr
Eater is a transmembrane protein that mediates phagocytosis in Drosophila. eater was identified in a microarray analysis of genes downregulated in S2 cells, in which Serpent had been knocked down by RNAi. The gene was shown to be expressed ...
Dominant activation of the hedgehog signaling pathway alters development of the female reproductive tract [0.03%]
Hedgehog信号通路活性增强会改变雌性生殖道的发育路径
Fernando F Migone,Yi Ren,Robert G Cowan et al.
Fernando F Migone et al.
The role of hedgehog (HH) signaling in reproductive tract development was studied in mice in which a dominant active allele of the signal transducer smoothened (SmoM2) was conditionally expressed in the Müllerian duct and ovary. Mutant fem...
Hui Liu,Wei Wang,Su-Kit Chew et al.
Hui Liu et al.
Cre-loxP recombination is widely used for genetic manipulation of the mouse genome. Here, we report generation and characterization of a new Cre line, Stella-Cre, where Cre expression cassette was targeted to the 3' UTR of the Stella locus....
Mouse strains for the ubiquitous or conditional overexpression of the Flii gene [0.03%]
泛在或条件性的Flii基因过表达小鼠品系
Nicole Thomsen,Anna Chappell,Radiya G Ali et al.
Nicole Thomsen et al.
The gelsolin related actin binding protein, Flii, is able to regulate wound healing; mice with decreased Flii expression show improved wound healing whereas mice with elevated Flii expression exhibit impaired wound healing. In both mice and...
Paul M Kulesa,Mary E Dickinson,Anna-Katerina Hadjantonakis
Paul M Kulesa
Generation of transgenic mice overexpressing EfnB2 in endothelial cells [0.03%]
条件性过表达EphrinB2转基因小鼠的构建
Maëva Luxey,Julien Laussu,Thomas Jungas et al.
Maëva Luxey et al.
Genetic studies have shown that ephrin-B2 and its cognate EphB4 receptor are necessary for normal embryonic angiogenesis. Moreover, there is overwhelming evidence that ephrin-B2 is involved in tumor vascularization, yet its role in adult an...
Jennifer C Jemc
Jennifer C Jemc
Cell-cell signaling and adhesion are critical for establishing tissue architecture during development and for maintaining tissue architecture and function in the adult. Defects in adhesion and signaling can result in mislocalization of cell...
Maternal and zygotic requirements for src64 during Drosophila cellularization [0.03%]
Src64在果蝇细胞质形成过程中的母体和合子需求要求
Taylor C Strong,Jeffrey H Thomas
Taylor C Strong
Cellularization of the multinucleate Drosophila embryo occurs shortly after zygotic transcription begins. During cellular blastoderm morphogenesis, the microfilament cytoskeleton undergoes extensive reorganization. This cytoskeletal reorgan...