New Bapx1(Cre-EGFP) mouse lines for lineage tracing and conditional knockout studies [0.03%]
用于谱系追踪和条件性敲除研究的新Bapx1（Cre-EGFP）小鼠品系
V Sivakamasundari,Hsiao Yun Chan,Sook Peng Yap et al.
V Sivakamasundari et al.
To gain insight into the roles of various genes in development and to circumvent embryonic lethality that hinders genetic studies, lineage tracing and conditional knockout techniques have been widely performed on mice using the increasing n...
Tubby-RFP balancers for developmental analysis: FM7c 2xTb-RFP, CyO 2xTb-RFP, and TM3 2xTb-RFP [0.03%]
用于发育分析的Tubby-RFP平衡系：FM7c 2xTb-RFP、CyO 2xTb-RFP和TM3 2xTb-RFP
Cara Pina,Francesca Pignoni
Cara Pina
We report here the construction of Tubby-RFP balancers for the X, 2nd and 3rd chromosomes of Drosophila melanogaster. The insertion of a 2xTb-RFP transgene on the FM7c, CyO, and TM3 balancer chromosomes introduces two easily scorable, domin...
Daria Onichtchouk
Daria Onichtchouk
Gastrulation in vertebrates is a conserved process, which involves transition from cellular pluripotency to early precursors of ectoderm, mesoderm, and endoderm. Pluripotency control during this stage is far from being understood. Recent ge...
Cre-mediated recombination can induce apoptosis in vivo by activating the p53 DNA damage-induced pathway [0.03%]
cre介导的同源重组可通过激活p53 DNA损伤通路在体内诱导细胞凋亡
Jianjian Zhu,Minh-Thanh Nguyen,Eiichiro Nakamura et al.
Jianjian Zhu et al.
Cre-mediated apoptosis has been observed in many contexts in mice expressing Cre-recombinase and can confound the analysis of genetically engineered conditional mutant or transgenic alleles. Several mechanisms have been proposed to explain ...
Characterization of transgenic mice expressing cancer-associated variants of human NOTCH1 [0.03%]
携人NOTCH1癌基因变异的转基因小鼠的特征分析
Katherine E Berquam-Vrieze,Deborah A Swing,Lino Tessarollo et al.
Katherine E Berquam-Vrieze et al.
The Notch1 receptor plays a critical role in cell fate decisions during development. Activation of Notch signaling has been implicated in several types of cancer, particularly T-cell acute lymphoblastic leukemia (T-ALL). Consequently, sever...
Jing Zhou,Jose Sebastian,Ji-Young Lee
Jing Zhou
A key question about the development of multicellular organisms is how they precisely control the complex pattern formation during their growth. For plants to grow for many years, a tight balance between pluripotent dividing cells and cells...
Mouse transgenic lines that selectively label Type I, Type IIA, and Types IIX+B skeletal muscle fibers [0.03%]
选择性标记I型、IIA型和IIB型骨骼肌纤维的小鼠转基因品系
Joe V Chakkalakal,Shihuan Kuang,Mario Buffelli et al.
Joe V Chakkalakal et al.
Skeletal muscle fibers vary in contractile and metabolic properties. Four main fiber types are present in mammalian trunk and limb muscles; they are called I, IIA, IIX, and IIB, ranging from slowest- to fastest-contracting. Individual muscl...
A novel TaulacZ allele reveals a requirement for Pitx2 in formation of the mammillothalamic tract [0.03%]
新型TaulacZ等位基因揭示Pitx2在哺乳动物乳头丘脑束形成中的作用要求
Jennifer M Skidmore,Mindy R Waite,Gonzalo Alvarez-Bolado et al.
Jennifer M Skidmore et al.
The hypothalamic mammillary region is critical for spatial memory and vestibular processing. Pitx2 encodes a paired-like transcription factor that is highly expressed in the developing mammillary region and is required for subthalamic nucle...
Reelina Basu,Li-Feng Zhang
Reelina Basu
Each mammalian female cell transcriptionally inactivates one X chromosome to balance X-linked gene dosage between males and females. This phenomenon, called X chromosome inactivation, is a perfect epigenetic event, in which two chromosomes ...