The Notch-regulated ankyrin repeat protein is required for proper anterior-posterior somite patterning in mice [0.03%]
Notch调节的ankyrin重复蛋白是小鼠正确体节前后模式形成所必需的
Luke T Krebs,Cara K Bradley,Christine R Norton et al.
Luke T Krebs et al.
The Notch-regulated ankyrin repeat protein (Nrarp) is a component of a negative feedback system that attenuates Notch pathway-mediated signaling. In vertebrates, the timing and spacing of formation of the mesodermal somites are controlled b...
Highlighted article: "Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling" by K. Lenton, A. W. James, A. Manu, S. A. Brugmann, D. Birker, E. R. Nelson, P. Leucht, J. A. Helms and M. T. Longaker [0.03%]
高亮论文：“Indian hedgehog通过正向调节颅骨骨化和调节骨形态发生蛋白信号通路在小头畸形发病机制中发挥作用”作者：K.Lenton，A.W.James，A.Manu，S.A.Brugmann，D.Birker，E.R.Nelson，P.Leucht，J.A.Helms and M.T.Longaker
Toward an unbiased evolutionary platform for unraveling Xenopus developmental gene networks [0.03%]
无偏向的进化平台揭示非洲爪蟾发育基因网络
Ronny Beer,Florian Wagner,Vladislav Grishkevich et al.
Ronny Beer et al.
The availability of both the Xenopus tropicalis genome and the soon to be released Xenopus laevis genome provides a solid foundation for Xenopus developmental biologists. The Xenopus community has presently amassed expression data for ∼2,3...
Shuichi Watanabe,Shoko Matsushita,Michiko Hayasaka et al.
Shuichi Watanabe et al.
The homeobox gene Lbx1 not only plays critical roles in myogenesis and neurogenesis during embryonic development but is also expressed in activated satellite cells of adult mice. To address the potential postnatal functions of Lbx1, we gene...
Jie Fang,Wen-Cheng Zhang,Tetsuji Yamashita et al.
Jie Fang et al.
Outer hair cells (OHCs) in the cochlea are crucial for the remarkable hearing sensitivity and frequency tuning. To understand OHC physiology and pathology, it is imperative to use mouse genetic tools to manipulate gene expression specifical...
Optimized transgenesis in Xenopus laevis/gilli isogenetic clones for immunological studies [0.03%]
非洲爪蟾/gilli同基因克隆的优化转基因技术应用于免疫学研究
Hristina Nedelkovska,Jacques Robert
Hristina Nedelkovska
Xenopus laevis provides a unique animal model, alternative to mouse, to study immunology. Even though, several methodologies have been developed for the generation of transgenic Xenopus, to date none have been adapted for the X. laevis/gill...
Gene induction in mature oligodendrocytes with a PLP-tTA mouse line [0.03%]
采用PLP-tTA小鼠系诱导少突胶质细胞成熟期的基因表达
Naoko Inamura,Shouta Sugio,Wendy B Macklin et al.
Naoko Inamura et al.
Mature oligodendrocytes are critical for myelin maintenance. To understand the molecular basis for this, genetic manipulation of mature oligodendrocytes is needed. Here we generated a mature oligodendrocyte tTA (tetracycline-controlled tran...
Cell plasticity in Caenorhabditis elegans: from induced to natural cell reprogramming [0.03%]
秀丽隐杆线虫细胞可塑性：从诱导式重编程序到自然式重编程
Martina Hajduskova,Arnaud Ahier,Thomas Daniele et al.
Martina Hajduskova et al.
Achieving controlled reprogramming of differentiated cells into a desired cell type would open new opportunities in stem-cell biology and regenerative medicine. Experimentation on cell reprogramming requires a model in which cell conversion...
A recombinase-mediated cassette exchange-derived cyan fluorescent protein reporter allele for Pdx1 [0.03%]
用于Pdx1的重组酶介导的插入报告基因型的青色荧光蛋白突变体
Leah A Potter,Eunyoung Choi,Susan B Hipkens et al.
Leah A Potter et al.
Fluorescent protein (FP) reporter alleles are useful both for identifying and purifying specific cell populations in the mouse. Here, we report the generation of mouse embryonic stem cells that contain a pancreatic and duodenal homeobox 1 (...
Ubiquitin-proteasome system components are upregulated during intestinal regeneration [0.03%]
泛素-蛋白酶体系统组分在肠再生期间表达上调
Consuelo Pasten,Pablo A Ortiz-Pineda,José E García-Arrarás
Consuelo Pasten
The ubiquitin proteasome system (UPS) is the main proteolytic system of cells. Recent evidence suggests that the UPS plays a regulatory role in regeneration processes. Here, we explore the possibility that the UPS is involved during intesti...