Data- and theory-driven approaches for understanding paths of epithelial-mesenchymal transition [0.03%]
基于数据和理论的上皮间质转化路径研究方法
Tian Hong,Jianhua Xing
Tian Hong
Reversible transitions between epithelial and mesenchymal cell states are a crucial form of epithelial plasticity for development and disease progression. Recent experimental data and mechanistic models showed multiple intermediate epitheli...
An oocyte-specific Cas9-expressing mouse for germline CRISPR/Cas9-mediated genome editing [0.03%]
一种卵母细胞特异性表达Cas9的小鼠用于生殖系的CRISPR/Cas9基因组编辑
Denise G Lanza,Jianqiang Mao,Isabel Lorenzo et al.
Denise G Lanza et al.
Cas9 transgenes can be employed for genome editing in mouse zygotes. However, using transgenic instead of exogenous Cas9 to produce gene-edited animals creates unique issues including ill-defined transgene integration sites, the potential f...
Deficits in olfactory system neurogenesis in neurodevelopmental disorders [0.03%]
神经发育障碍中的嗅觉系统神经发生缺陷
Sean C Sweat,Claire E J Cheetham
Sean C Sweat
The role of neurogenesis in neurodevelopmental disorders (NDDs) merits much attention. The complex process by which stem cells produce daughter cells that in turn differentiate into neurons, migrate various distances, and form synaptic conn...
Molecular mechanisms of differentiation and class choice of olfactory sensory neurons [0.03%]
嗅觉感觉神经元分化和类别选择的分子机制
Junji Hirota
Junji Hirota
The sense of smell is intricately linked to essential animal behaviors necessary for individual survival and species preservation. During vertebrate evolution, odorant receptors (ORs), responsible for detecting odor molecules, have evolved ...
The Prl3d1-Cre mouse line selectively induces the expression of Cre recombinase in parietal trophoblast giant cells [0.03%]
Prl3d1-Cre小鼠系选择性地在胎盘滋养层巨细胞中诱导Cre重组酶的表达
Linqing Pan,Fuquan Zhu,Aochen Yu et al.
Linqing Pan et al.
The placenta plays a pivotal role in the maintenance of normal pregnancy, but how it forms, matures, and performs its function remains poorly understood. Here, we describe a novel mouse line (Prl3d1-iCre) that expresses iCre recombinase und...
Generation of a Dcx-CreERT2 knock-in mouse for genetic manipulation of newborn neurons [0.03%]
Dcx-CreERT2 条件性基因打靶小鼠的构建及其在新生神经元遗传操作中的应用初探
Gabriella A Perez,Kyung-Won Park,Denise Lanza et al.
Gabriella A Perez et al.
A wide variety of CreERT2 driver lines are available for genetic manipulation of adult-born neurons in the mouse brain. These tools have been instrumental in studying fate potential, migration, circuit integration, and morphology of the ste...
Epithelial-to-mesenchymal plasticity from development to disease: An introduction to the special issue [0.03%]
从发育到疾病上皮间质可塑性的介绍——特刊序言
Hervé Acloque,Jing Yang,Eric Theveneau
Hervé Acloque
Epithelial-Mesenchymal Transition (EMT) refers to the ability of cells to switch between epithelial and mesenchymal states, playing critical roles in embryonic development, wound healing, fibrosis, and cancer metastasis. Here, we discuss so...
Generation of tamoxifen-inducible Tfap2b-CreERT2 mice using CRISPR-Cas9 [0.03%]
利用CRISPR-Cas9技术制备他莫昔芬诱导型Tfap2b-CreERT2小鼠品系
Mingyi Zhang,Jifan Feng,Yue Li et al.
Mingyi Zhang et al.
Tfap2b, a pivotal transcription factor, plays critical roles within neural crest cells and their derived lineage. To unravel the intricate lineage dynamics and contribution of these Tfap2b+ cells during craniofacial development, we establis...
Ute Rothbächer
Ute Rothbächer
Women in tunicate research: Pioneers of the past and their present legacy [0.03%]
环节动物苔藓虫研究中的女性：过去的先锋和现在的遗产
Marie L Nydam,Mary Beth Saffo,Anna Di Gregorio
Marie L Nydam
The search for female scientists who pioneered the research on tunicates is hindered by the tradition of reporting only the first initials of authors' names on scientific publications using only the initials of their first names. While this...