Current Perspectives on Mesenchymal Stem Cells as a Potential Treatment for Periodontal Diseases and Conditions [0.03%]
有关间充质干细胞作为牙周病和条件潜在治疗的当前观点
Shuyu Cai,Cong Li,Biaowen Wei et al.
Shuyu Cai et al.
Periodontal diseases, including periodontitis and gingivitis, constitute a major global health burden, affecting over 1 billion people worldwide. These conditions typically initiate in adulthood and progress chronically, often exhibiting se...
Development of a Hepatocyte-Specific Temporal Genetic Mouse Model Using Albumin Promoter-Driven FlpER2 Expression [0.03%]
利用白蛋白启动子驱动的FlpER2表达建立肝细胞特异性时空遗传小鼠模型
Bin Wang,Jiale Wang,Yang Liu et al.
Bin Wang et al.
Tissue-specific gene manipulation using Cre/loxP or Flp/frt recombination systems is a cornerstone of genetically engineered mouse models. In this study, we aim to develop a novel hepatocyte-specific, tamoxifen-inducible Flp mouse line. BAC...
Tracing Early Migratory Neurons in the Developing Nose Using Contactin-2 (Cntn2) CreERT2 [0.03%]
利用Contactin-2 (Cntn2) CreERT2追踪发育中鼻部的早期迁徙神经元
Enrico Amato Jr,Alexis M Semon,Paolo E Forni
Enrico Amato Jr
Neuronal migration during embryonic development is a fundamental process. In the developing nose of rodents, neurons that form during early neurogenic waves in the olfactory placode leave this structure to migrate toward or into the develop...
Identification and Classification of Zinc Finger Proteins Encoded in the Genome of an Ascidian [0.03%]
刺 ascidians 基因组中锌指蛋白的鉴定与分类
Natsuko Tamura,Yutaka Satou
Natsuko Tamura
Genes encoding C2H2-type zinc finger (ZF) proteins constitute one of the largest gene families in animal genomes. Many C2H2-type ZF domains are used for DNA-binding, and others are used for protein-protein interactions and RNA-binding. In a...
Generation of Plexin-B1 Conditional Knockout Mouse With CRISPR/Cas9 Technology [0.03%]
CRISPR/Cas9技术生成Plexin-B1条件性敲除小鼠
Haofei Ni,Kevin Kelley,Ning Xie et al.
Haofei Ni et al.
Plexins are axon guidance transmembrane receptors that control cytoskeleton and membrane dynamics in development and adult physiology. As plexins are expressed in multiple cell types in various tissues, floxed alleles that enable conditiona...
Genetic Mechanism That Defines the Characteristic Neurogenesis Patterns in the Neural Plate Using Hes/her Genes During Early Vertebrate Development [0.03%]
hes/her基因在早期脊椎动物发育中界定神经板特征性神经生成模式的遗传机制研究
Takero Ohyanagi,Hiroki Tokizaki,Takehisa Sato et al.
Takero Ohyanagi et al.
In the early zebrafish neural plate, proneural cluster domains are defined by surrounding neural progenitor pools (NPPs), generating primary neurogenesis patterns. In each NPP, several Notch-independent Hes/her-type genes are expressed in d...
Karyn Jourdeuil,Karen M Neilson,Andre L P Tavares et al.
Karyn Jourdeuil et al.
To identify novel Six1-interacting proteins, we previously screened the fly interactome for Sine oculis-binding partners whose orthologues are also expressed in Xenopus embryos. We identified a zinc-finger MYM-containing protein-Zmym2-based...
Excluding the Genomic Location of Pax2 Regulatory Elements for the Developing Mouse Eye [0.03%]
排除Pax2调控元件在小鼠眼发育过程中的基因组位置
Tzu-Hua Ho,Daniela Santamaria-Munoz,Hollin Hamelynck et al.
Tzu-Hua Ho et al.
The Pax2 transcription factor is activated uniformly in the optic vesicle/cup, but becomes progressively restricted to the forming optic disc and stalk. In the eye, it is not known how Pax2 expression is regulated and progressively restrict...
Junying Gao,Lindong Yu,Haoran Qi et al.
Junying Gao et al.
Single-cell RNA sequencing (scRNA-seq) is a rapidly developing and useful technique for elucidating biological mechanisms and characterizing individual cells. Tens of millions of patients worldwide suffer from heart injuries and other types...
Generation of Myeloid-Specific Bmal1 Knockout Mice and Identification of Bmal1-Regulated Ferroptosis in Macrophages [0.03%]
BMAL1调控的髓系细胞铁死亡小鼠模型的构建及其机制研究
Qing Chen,Wenyi Wang,Weijun Fang et al.
Qing Chen et al.
Circadian clocks have a fundamental role in many physiological processes. Bmal1 (basic helix-loop-helix ARNT like 1) is a central master circadian clock gene. The global Bmal1 knockout mice were shown to have a loss of circadian rhythms, ac...