Heat shock protein 2 promoter drives Cre expression in spermatocytes of transgenic mice [0.03%]
热休克蛋白2启动子在转基因小鼠的精母细胞中驱动Cre表达
Amy L Inselman,Noriko Nakamura,Paula R Brown et al.
Amy L Inselman et al.
We generated transgenic mouse line C57BL/6-Tg(Hspa2-cre)1Eddy/J (Hspa2-cre), which expresses cre-recombinase under the control of a 907-bp fragment of the heat shock protein 2 (Hspa2) gene promoter. Transgene expression was determined using...
Construction of a dual affinity tagged allele of the Rb1 tumor suppressor gene in the mouse [0.03%]
在小鼠中构建Rb1肿瘤抑制基因的双重亲和标记等位基因
Hai Xiao,Xiaojing Zhang,David W Goodrich
Hai Xiao
Loss of Rb1 tumor suppressor gene function is involved in the genesis of most human cancers. Novel therapies targeting Rb1 have been slow to develop because of our incomplete understanding of its molecular mechanisms of action. Rb1 protein ...
alphaPS1betaPS integrin receptors regulate the differential distribution of Sog fragments in polarized epithelia [0.03%]
极化上皮中αPS1βPS整合素受体调控Sog片段的差异分布
Erika Negreiros,Marcio Fontenele,Amanda R Câmara et al.
Erika Negreiros et al.
Bone morphogenetic proteins (BMPs) have important functions during epithelial development. In Drosophila, extracellular Short gastrulation (Sog) limits the action of the BMP family member Decapentaplegic (Dpp). We have shown that Integrin r...
Julia E Herrmann,Morgan A Pence,Emanuel A Shapera et al.
Julia E Herrmann et al.
Ephrins and Eph receptor tyrosine kinases are cell-surface molecules that serve a multitude of functions in cell-cell communication in development, physiology, and disease. EphA4 is a promiscuous member of the EphA subclass of Eph receptors...
Inducible cardiomyocyte-specific gene disruption directed by the rat Tnnt2 promoter in the mouse [0.03%]
由鼠Tnnt2启动子定向的可诱导的心肌细胞特异性基因敲除模型
Bingruo Wu,Bin Zhou,Yidong Wang et al.
Bingruo Wu et al.
We developed a conditional and inducible gene knockout methodology that allows effective gene deletion in mouse cardiomyocytes. This transgenic mouse line was generated by coinjection of two transgenes, a "reverse" tetracycline-controlled t...
Evidence that the C-terminal domain (CtD) autoinhibits neural repression by Drosophila E(spl)M8 [0.03%]
果蝇E(spl)M8的C端结构域（CtD）自动抑制神经抑制的证据
Bhaskar Kahali,Jee-Eun Kim,Umesh Karandikar et al.
Bhaskar Kahali et al.
Analysis of the retinal defects of a CK2 phosphomimetic variant of E(spl)M8 (M8S(159)D) and the truncated protein M8* encoded by the E(spl)D allele, suggest that the nonphosphorylated CtD "autoinhibits" repression. We have investigated this...
Gohar Mazmanian,Michael Kovshilovsky,Debbie Yen et al.
Gohar Mazmanian et al.
Nodal-signaling is required for specification of mesoderm, endoderm, establishing left-right asymmetry, and craniofacial development. Wdr68 is a WD40-repeat domain-containing protein recently shown to be required for endothelin-1 (edn1) exp...
TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis [0.03%]
神经病理标志因子TDP-43对于小鼠早期胚胎发育是必不可少的
Lien-Szu Wu,Wei-Cheng Cheng,Shin-Chen Hou et al.
Lien-Szu Wu et al.
TDP-43 is a highly conserved and ubiquitously expressed nuclear protein. It has been implicated in the regulation of transcription, alternative splicing, translation, and neuronal plasticity. TDP-43 has also been shown to be a disease signa...
Sally A Moody
Sally A Moody
Sophie Colombo,Mayuko Kumasaka,Corrinne Lobe et al.
Sophie Colombo et al.
The Z/EG transgenic mouse line, produced by Novak et al., displays tissue-specific EGFP expression after Cre-mediated recombination. The autofluorescence of EGFP allows the visualization of cells of interest displaying Cre recombination. Th...