Generation of Tpbpα-iCre-EGFP Knock-In Mice for Trophoblast Subtype-Specific Gene Manipulation [0.03%]
Tpbpα-iCre-EGFP敲入小鼠的生成用于滋养层亚型特异性基因操控
Shaoqiang Ban,Chang&#x;e Mu,Mengqi Gu et al.
Shaoqiang Ban et al.
The placenta plays an essential role during pregnancy in mammals, with the placental endocrine trophoblast subtypes secreting many growth factors and cytokines to promote fetal growth and maternal adaptation. These endocrine cells, includin...
Transcriptomic Analysis of Skeletal Muscle Systems Comparing Bovines, Humans, and Mice Using scRNA-Seq [0.03%]
基于scRNA-seq的牛、人和小鼠骨骼肌系统转录组分析
Cuicui Cai,Xueyao Yang,Hui Wang et al.
Cuicui Cai et al.
Skeletal muscle is the most widespread tissue in mammals and mediates several functions, and whose development is controlled by a coordinated transcriptional hierarchy that regulates the activities of a range of muscle genes. Skeletal muscl...
Comparative Study
Genesis (New York, N.Y. : 2000). 2025 Dec;63(6):e70035. DOI:10.1002/dvg.70035 2025
New CHARGE Syndrome Mouse Models Reveal the Contribution of the Enzymatic Activity of CHD7 in Pathogenesis [0.03%]
新的CHARGE综合征小鼠模型揭示了CHD7酶活性在发病机制中的作用
Ze Wang,Shuhua Dong,Zhuxi Huang et al.
Ze Wang et al.
Genetic variants of CHD7, encoding a chromatin remodeler, lead to CHARGE syndrome with congenital deficits in multiple organs. One crucial unsolved question is the causal mechanisms of most protein-altering variants of CHD7. One hypothesis ...
Mauro Magaña-Acosta,Viviana Valadez-Graham
Mauro Magaña-Acosta
Chromatin remodeling proteins are evolutionarily conserved factors involved in a wide range of biological processes. In this review, we describe ATRX, a chromatin remodeling protein belonging to the SWI/SNF2 family. Its association with dif...
NOLC1 as Key Regulator of NPR1 (Coding for NPRA) Transcription in Endothelial Senescence [0.03%]
NOLC1作为NPR1（编码NPRA）转录调控因子在血管内皮细胞衰老中的作用
Cui Cui,Wanli Xiao,Jiankun Liu et al.
Cui Cui et al.
Vascular endothelial cell senescence is closely associated with cardiovascular disease. The deficiency of natriuretic peptide receptor A (NPRA), encoded by the natriuretic peptide receptor 1 (NPR1) gene, contributes to vascular endothelial ...
Marie L Nydam,Devon Gamble,Tal Gordon et al.
Marie L Nydam et al.
Generation of Knock-In Syrian Hamsters via Zygote Microinjection Using CRISPR/Cas9 Genome Editing [0.03%]
基于CRISPR/Cas9基因编辑的仓鼠受精卵显微注射敲入技术
Mayo Shigeta,Ken-Ichi Inoue,Naoko Shimada et al.
Mayo Shigeta et al.
Syrian hamsters (Mesocricetus auratus) have long served as valuable model organisms in diverse research fields such as oncology, immunology, and physiology owing to their unique biological and pathological characteristics. Although embryo m...
Generation of Astrocyte-Selective Cre Driver Lines With Distinct Onsets of Recombination Activity During Development [0.03%]
具有不同发育时期重组活性的星形胶质细胞谱系选择性Cre驱动品系的建立
Yukina Izumi,Tomoya Nakatani,Harumi Takai et al.
Yukina Izumi et al.
Astrocytes are a major glial cell type, playing multiple roles in the development, function, and pathogenesis of the brain. Accordingly, neuronal-astrocyte communication is an important research area. However, because these cell types share...
A Cxcl15 Cre Recombinase Mouse Model Useful to Study Gland Development in the Uterus [0.03%]
一种可用于研究子宫腺体发育的Cxcl15 Cre重组酶小鼠模型
Andrew M Kelleher,Hong Im Kim,Greeshma Sai Bayammagari et al.
Andrew M Kelleher et al.
The mammalian uterus contains glands in the endometrium that develop only or primarily after birth. In the mouse, endometrial glands govern post implantation pregnancy establishment via regulation of blastocyst implantation, stromal cell de...
Expression Patterns of sfrp Genes During Regeneration in the Holothurian Eupentacta fraudatrix [0.03%]
Eupentacta fraudatrix 海参再生过程中sfrp基因的表达模式研究
Konstantin Sadriev
Konstantin Sadriev
Secreted Frizzled-related proteins (SFRPs) are a small, ancient family of extracellular signaling pathway agonists and antagonists. In this study, we examined their expression patterns during regeneration in the holothurian Eupentacta fraud...