Association of Frailty With Dementia and the Mediating Role of Brain Structure and Immunometabolic Signatures [0.03%]
脆弱性与痴呆症的关联及其脑结构和免疫代谢标志物的作用中介效应分析
Xiangying Suo,Lifeng Li,Jing Guo et al.
Xiangying Suo et al.
Background and objectives: Physical frailty is associated with a higher risk of developing dementia, but it remains unclear whether this relationship is causal and whether the biological biomarkers and neurologic underlyi...
Buffered Cortisol Response to Stress in Patients With Epilepsy and Its Association With Memory and Quality of Life [0.03%]
癫痫患者的应激促肾上腺皮质激素释放缓释反应及其与记忆和生活质量的关系
Judit Catalán-Aguilar,Esperanza González-Bono,Vicente Villanueva et al.
Judit Catalán-Aguilar et al.
Background and objectives: Epilepsy is a chronic stress condition associated with dysregulation in the hypothalamic-pituitary-adrenal axis and cognitive and emotional comorbidities. Therefore, we aimed to examine the acut...
Randomized Controlled Trial
Neurology. 2025 Oct 7;105(7):e214103. DOI:10.1212/WNL.0000000000214103 2025
Clinical Reasoning: A Woman With Subacute Progression of Distal Upper Extremity Weakness [0.03%]
临床诊断：慢性进行性远端上肢无力女性患者的诊疗思路
Amanda Jin Zhao,Saami Zakaria,Julia H Greenberg et al.
Amanda Jin Zhao et al.
A 65-year-old woman presented with 3 months of progressive hand weakness, initially with distal-predominant symptoms. EMG was notable for diminished amplitudes in bilateral radial nerves without evidence of conduction block and with normal ...
Case Reports
Neurology. 2025 Oct 21;105(8):e214212. DOI:10.1212/WNL.0000000000214212 2025
Diffusion Tensor Imaging Along the Perivascular Space (DTI-ALPS): Still Mountains to Climb [0.03%]
沿血管周隙的弥散张量成像（DTI-ALPS）：仍需努力攀登高峰
Baijayanta Maiti,Joel S Perlmutter
Baijayanta Maiti
Association of DTI-ALPS Glymphatic Index With Differential Phenoconversion in Isolated REM Sleep Behavior Disorder: A Multi-Cohort MRI Study [0.03%]
弥散张量成像淋巴管指数与孤立性快动眼睡眠行为障碍表型转化的关系：多队列磁共振成像研究
Violette Ayral,Alexandre Pastor-Bernier,Véronique Daneault et al.
Violette Ayral et al.
Background and objectives: Isolated REM sleep behavior disorder (iRBD) is the strongest prodromal marker of synucleinopathies, including Parkinson disease (PD) and dementia with Lewy bodies (DLB). Identifying brain biomar...
Multicenter Study
Neurology. 2025 Oct 7;105(7):e214042. DOI:10.1212/WNL.0000000000214042 2025
Multimarker Cerebral Small Vessel Disease Score and Risk of Incident Dementia in the Framingham Heart Study [0.03%]
弗明汉心脏研究中的多标记小血管疾病评分与新发痴呆风险的关系
Adlin Pinheiro,Oluchi Ekenze,Hugo J Aparicio et al.
Adlin Pinheiro et al.
Background and objectives: Individual MRI markers of cerebral small vessel disease (CSVD) are associated with impaired cognition and dementia but may not reflect the overall burden of CSVD. In addition, it is unclear whet...
Observational Study
Neurology. 2025 Oct 7;105(7):e214113. DOI:10.1212/WNL.0000000000214113 2025
Pearls & Oy-sters: Adult-Onset Coats Plus: A Case of Leukoencephalopathy With Calcifications, a Tumefactive Brain Lesion, and a Presumed Autoimmune Disease [0.03%]
珍珠与Oy-ster：成人期Coats加号病例：伴钙化、肿块样脑病变和疑似自身免疫性疾病的白质脑病
Catarina Serrão,Romana Rodrigues,Carla Leão Guerreiro et al.
Catarina Serrão et al.
Coats plus (Cp) is a pleiotropic disorder with multisystemic manifestations including retinal vascular disease and leukoencephalopathy with intracranial calcifications and cysts. It is an autosomal recessive telomere biology disorder mostly...
Case Reports
Neurology. 2025 Oct 7;105(7):e214124. DOI:10.1212/WNL.0000000000214124 2025
Child Neurology: Parainfectious Anti-NMDAR Encephalitis With Anti-MOG and Anti-AQP4 Seropositivity in an Infant [0.03%]
儿科神经病学：婴儿感染相关抗NMDAR脑炎伴抗MOG和抗AQP4阳性
Kriti Nautiyal,Sayoni Roy Chowdhury,Rashmi Meena et al.
Kriti Nautiyal et al.
Overlap syndromes of anti-N-methyl-d-aspartate (NMDA) receptor encephalitis and myelin oligodendrocyte glycoprotein (MOG) or aquaporin-4 (AQP4)-mediated demyelination, either concurrently or sequentially, have been increasingly recognized. ...
Case Reports
Neurology. 2025 Oct 7;105(7):e214125. DOI:10.1212/WNL.0000000000214125 2025
Journal Club: Efficacy and Safety of IV Thrombolysis for Acute Ischemic Stroke Patients With Moyamoya Disease [0.03%]
journal club：颅内动脉粥样硬化性疾病急性缺血性卒中的静脉溶栓治疗疗效和安全性
A Zohaib Siddiqi,Nishita Singh
A Zohaib Siddiqi
The "Efficacy and Safety of IV Thrombolysis for Acute Ischemic Stroke Patients With Moyamoya Disease" study was a retrospective analysis of administrative data to examine the safety and efficacy of intravenous thrombolysis (IVT) in patients...
Clinical Reasoning: A 73-Year-Old Man With Progressive Proximal Muscle Weakness and Binocular Diplopia [0.03%]
临床推理：进行性近端肌肉无力和复视的73岁男性患者
Karl J Wold,Armand Amini,David Bargiela et al.
Karl J Wold et al.
Progressive weakness and diplopia have a wide differential diagnosis, which can be narrowed by obtaining a detailed history and performing a careful physical examination. It is essential to determine whether these 2 symptoms are due to a si...
Case Reports
Neurology. 2025 Oct 7;105(7):e214173. DOI:10.1212/WNL.0000000000214173 2025