Statistical Mistakes Associated With Preclinical-to-Clinical Phase 2 Translation Failure: The Data Does Not Lie [0.03%]
从临床前到一期临床试验失败与统计学错误：数据不会撒谎
Wesley T Kerr,Katherine N McFarlane
Wesley T Kerr
Association of Statistical Methodology and Design in Preclinical Animal Studies With Successful Translation Into Clinical Phase 2 Trials [0.03%]
前期动物实验的统计方法和设计与临床二期试验成功的关联性研究
Olivia Hogue,Megan Zelinsky,Claire Sonneborn et al.
Olivia Hogue et al.
Background and objectives: Preclinical-to-clinical translational failure is common in neurologic research. Reasons for translational failure are complex and multifaceted, but it is increasingly recognized that translation...
Uncovering Clinical and Functional Neuroimaging Characteristics of Overt Stage Phenotypes Within the α-Synucleinopathy Spectrum [0.03%]
解码α-突触核蛋白病谱系内明确阶段表型的临床和神经影像功能特征
Beatrice Orso,Pietro Mattioli,Francesco Famà et al.
Beatrice Orso et al.
Background and objectives: Dementia with Lewy bodies (DLB) and Parkinson disease (PD), especially when associated with REM sleep behavior disorder (RBD), represent partially overlapping phenotypes of overt α-synucleinopa...
What Are the Proposed Mechanisms Contributing to the Manifestations of Anti-NMDAR Encephalitis? [0.03%]
抗NMDAR脑炎发病机制的研究进展
Andreu Vilaseca,Josep O Dalmau,Eduardo Benarroch
Andreu Vilaseca
Anti-NMDA receptor (NMDAR) encephalitis is the first well-characterized autoimmune disorder caused by autoantibodies directed against neuronal surface proteins in the CNS.1-3 Initially described in patients with ovarian teratoma,2 this diso...
Diffusion MRI Tractography to Reduce Risks of Postoperative Neurologic Deficits: A Systematic Review and Meta-Analysis [0.03%]
基于弥散磁共振纤维束追踪术减少术后神经功能障碍风险的系统评价和Meta分析
Guido I Guberman,Neevya Balasubramaniam,Liam Wilson et al.
Guido I Guberman et al.
Background and objectives: Despite informing on the location of functionally relevant white matter tracts, diffusion MRI tractography is not routinely used to guide neurosurgical procedures. The potential of tractography ...
Meta-Analysis
Neurology. 2025 Nov 11;105(9):e214145. DOI:10.1212/WNL.0000000000214145 2025
Disentangling the Clinical and Neuroimaging Spectrum of Neuronal α-Synucleinopathies: The Role of REM Sleep Behavior Disorder [0.03%]
解剖神经元α-突触核蛋白病的临床和影像学谱系：快速眼动睡眠行为障碍的作用
Fabricio F Oliveira,Rawan Tarawneh
Fabricio F Oliveira
Surgical Complications of Deep Brain Stimulation in Children Across Targets and Indications: Multicenter Analysis of the CHILD-DBS Registry [0.03%]
儿童深部脑刺激手术并发症：来自CHILD-DBS注册中心多中心分析结果的不同靶点和适应证并发症研究
Arjun Balachandar,Leonard H Verhey,Karim Mithani et al.
Arjun Balachandar et al.
Background and objectives: Deep brain stimulation (DBS) is considered off-label and investigational in pediatric populations with some exceptions. There are limited data on the relative rates of complications after DBS ac...
Multicenter Study
Neurology. 2025 Nov 11;105(9):e214201. DOI:10.1212/WNL.0000000000214201 2025
Machine Learning Models to Predict Withdrawal of Life-Sustaining Therapy in Patients With Severe Traumatic Brain Injury [0.03%]
预测重度创伤性脑损伤患者生命维持治疗撤除的机器学习模型
Michael Cobler-Lichter,Jessica M Delamater,Fernanda J P Teixeira et al.
Michael Cobler-Lichter et al.
Background and objectives: Over half of all deaths after traumatic brain injury (TBI) follow the decision to withdraw life-sustaining therapy (WLST). Despite recent improvements in TBI mortality, rates of WLST have remain...
Observational Study
Neurology. 2025 Nov 11;105(9):e214249. DOI:10.1212/WNL.0000000000214249 2025
Thrombolysis Alone vs With Argatroban or Eptifibatide: A Prespecified Subgroup Analysis of the MOST Trial [0.03%]
组织型纤溶酶原激活剂联合用药相比单独使用治疗急性冠脉综合征的预设亚组分析研究
Akash Roy,Jordan Elm,James R Ingles et al.
Akash Roy et al.
Background and objectives: IV thrombolysis only (IVT-O) is the primary reperfusion therapy for most stroke patients. At least 50% of IVT-O patients remain disabled. We assessed 2 therapies added to IVT-O aimed at increasi...
Clinical Trial
Neurology. 2025 Nov 11;105(9):e214228. DOI:10.1212/WNL.0000000000214228 2025
Core Clinical Features Associated With Survival in Patients With Dementia With Lewy Bodies [0.03%]
与路易体痴呆患者生存率相关的临床特征分析
Stuart J McCarter,Tanis J Ferman,Kiera M Grant et al.
Stuart J McCarter et al.
Background and objectives: This analysis used clinical data from prospectively followed participants meeting criteria for probable dementia with Lewy bodies (DLB) in the Mayo Clinic Alzheimer's Disease Research Center (AD...