Keeping Time With the 24-Hour Brain: What Rest-Activity Rhythms Reveal About Dementia Risk [0.03%]
昼夜节律与痴呆风险的关系
Yi Fang,Yue Leng
Yi Fang
Risk of New Indications for Anticoagulants and Thrombolytics in People With Cognitive Impairment: Implications for Anti-Amyloid Therapy [0.03%]
凝血剂和溶栓剂在认知障碍患者中出现新适应症的风险：针对抗淀粉样蛋白治疗的影响
Anna L Parks,Jacquelyn M Lykken,Meghan L Rieu-Werden et al.
Anna L Parks et al.
Objectives: Anticoagulants and thrombolytics may interact with anti-amyloid monoclonal antibodies (mAbs) to increase intracranial hemorrhage risk, so expert guidance recommends against their co-prescription. We aimed to e...
Association Between Circadian Rest-Activity Rhythms and Incident Dementia in Older Adults: The Atherosclerosis Risk in Communities Study [0.03%]
动脉粥样硬化多中心研究中老年人昼夜节律与新发痴呆之间的关联
Wendy Wang,Amal A Wanigatunga,Lacey H Etzkorn et al.
Wendy Wang et al.
Background and objectives: Aging is associated with changes in circadian rhythms. Rest-activity rhythms (RARs) measured using accelerometers are markers of circadian rhythms. Altered circadian rhythms may be risk factors ...
Multicenter Study
Neurology. 2026 Jan 27;106(2):e214513. DOI:10.1212/WNL.0000000000214513 2026
Association of Plasma GFAP and NfL in Middle-Aged Adults With MRI Markers of Cerebral Small Vessel Disease Later in Life [0.03%]
中年血浆GFAP和NfL水平与晚年脑小血管病MRI标志物的相关性研究
Savvina Prapiadou,Benjamin Y Q Tan,Tamara N Kimball et al.
Savvina Prapiadou et al.
Background and objectives: Cerebral small vessel disease (cSVD) is a major contributor to stroke and dementia, often beginning decades before clinical symptoms appear. While MRI markers offer critical insight into cSVD bu...
Revisiting the Optimal Apparent Diffusion Coefficient Threshold for Ischemic Core Delineation [0.03%]
缺血核心界定的最优表观扩散系数阈值的再评估
Clara Cohen,Clément Debacker,Alice Le Berre et al.
Clara Cohen et al.
Background and objectives: The widely used apparent diffusion coefficient (ADC) threshold of 620 × 10-6 mm2/s to automatically delineate the ischemic core on diffusion-weighted imaging (DWI) was established in recanalize...
Temporal Dynamics and Cross-Sectional and Longitudinal Factors Associated With Motor Reserve and Outcome in Patients With Parkinson Disease [0.03%]
帕金森病患者的运动代偿储备的时长动态及其横断面和纵向影响因素与预后的关系
Kazuto Tsukita,Akihiro Kikuya,Kenji Yoshimura et al.
Kazuto Tsukita et al.
Background and objectives: "Motor reserve" refers to the brain's dynamic resilience against dopaminergic degeneration in Parkinson disease (PD). However, its clinical significance remains unclear because of critical limit...
Observational Study
Neurology. 2026 Jan 27;106(2):e214475. DOI:10.1212/WNL.0000000000214475 2026
Fast Ripples Measured From Overnight SEEG Recordings as Markers of the Epileptogenic Zone: A Multicenter Validation Study [0.03%]
快速尖波作为癫痫源区标志的多中心验证研究
Päivi Nevalainen,Nicolás von Ellenrieder,Roy W R Dudley et al.
Päivi Nevalainen et al.
Background and objectives: Epilepsy surgery outcomes after intracranial EEG remain suboptimal necessitating the discovery of additional biomarkers to define the epileptogenic zone. Fast ripples (FRs) are a promising, new ...
Multicenter Study
Neurology. 2026 Jan 27;106(2):e214511. DOI:10.1212/WNL.0000000000214511 2026
Nadja Korajkic,Vincent N Thijs
Nadja Korajkic
Whole-Brain Dynamic Causal Tractography Atlas of Auditory and Visual Speech Networks Derived From Intracranial Neurophysiologic Data [0.03%]
基于颅内神经生理数据的听觉和视觉言语网络的大脑动态因果追踪图谱
Ryuzaburo Kochi,Aya Kanno,Hiroshi Uda et al.
Ryuzaburo Kochi et al.
Background and objectives: Since Penfield's era, invasive neurophysiology has laid a lasting foundation for functional neuroscience by elucidating brain regions necessary for speech. Yet, whole-brain studies have not dist...
Observational Study
Neurology. 2026 Jan 27;106(2):e214448. DOI:10.1212/WNL.0000000000214448 2026