Modeling Disease Progression and Placebo Response in Huntington Disease: Insights From Enroll-HD and GENERATION HD1 Cohorts [0.03%]
亨廷顿舞蹈病的疾病进展和安慰剂反应模型：来自Enroll-HD和GENERATION HD1队列的见解
Marcelo Boareto,Yumi Yamamoto,Jeffrey D Long et al.
Marcelo Boareto et al.
Background and objectives: Huntington disease is a rare neurodegenerative disorder with no disease-modifying therapies. This study aimed to quantify longitudinal changes in Unified Huntington's Disease Rating Scale (UHDRS...
Clinical Trial
Neurology. 2025 May 27;104(10):e213646. DOI:10.1212/WNL.0000000000213646 2025
Teaching NeuroImage: Temporal Intermittent Rhythmic Delta Activity: An Epileptiform Equivalent [0.03%]
教学神经影像：时间间歇性三角波活动：一种癫痫等效物
Kaley J Marcinski Nascimento,Doyle Yuan,Adam S Greenblatt et al.
Kaley J Marcinski Nascimento et al.
Rebound Growth Following Temporary Discontinuation of BRAFi and MEKi in a Patient With Multifocal BRAFV600E-Mutant Primary Brain Tumor [0.03%]
短暂停用BRAFi和MEKi后，多发性BRAF V600E突变原发脑肿瘤患者的复发增长
Antonio Pisano,Samanta Cupini,Orazio Santo Santonocito et al.
Antonio Pisano et al.
Published Erratum
Neurology. 2025 May 27;104(10):e213621. DOI:10.1212/WNL.0000000000213621 2025
Associations of Accelerated Biological Aging With Dementia and the Mediation Role of Brain Structure: Findings From a Longitudinal Study [0.03%]
端粒加速衰老与痴呆症的关联及脑结构的中介作用：一项纵向研究发现
Yacong Bo,Liuqiao Sun,Shengsheng Hou et al.
Yacong Bo et al.
Background and objectives: The association between biological aging and dementia, as well as the underlying mechanism, remains limited. The aim of this study was to investigate the relationships of biological age (BA) wit...
Pearls & Oy-sters: ADCY5-Related Dyskinesia: From a Longstanding Misdiagnosis of Drug-Resistant Epilepsy [0.03%]
pearls & oy-sters adcy5相关运动障碍：长期误诊为难治性癫痫
Ana Moreno-Estébanez,Miriam Sánchez-Horvath,Ainhoa Marinas et al.
Ana Moreno-Estébanez et al.
ADCY5-related dyskinesia (ADCY5-RD) is a hyperkinetic movement disorder of childhood onset, resulting from pathogenic variants in the ADCY5 gene. Paroxysmal worsening of the movements and movements that occur in relation to sleep and/or awa...
Case Reports
Neurology. 2025 May 27;104(10):e213661. DOI:10.1212/WNL.0000000000213661 2025
Teaching NeuroImage: Primary Central Nervous System Vasculitis With Thalamic Involvement [0.03%]
神经影像教学：涉及丘脑的原发性中枢神经系统血管炎
Cansu Sarıkaya,Tolga Çetindamar,Aydın Sav et al.
Cansu Sarıkaya et al.
Long-Term Follow-Up Results of Antiseizure Medication Withdrawal in Grade 2 and 3 Glioma Patients: A Prospective Observational Study [0.03%]
抗癫痫药物减停用于2-3级胶质瘤患者的长期随访结果：一项前瞻性观察研究
Pim B van der Meer,Melissa Kerkhof,Linda Dirven et al.
Pim B van der Meer et al.
Background and objectives: The aim of this study was to evaluate the long-term results of seizure recurrence after antiseizure medication (ASM) withdrawal vs continuation in patients with diffuse glioma, grades 2 and 3. ...
Observational Study
Neurology. 2025 May 27;104(10):e213590. DOI:10.1212/WNL.0000000000213590 2025
Impact of Brain Frailty on Clinical Presentation and Neurologic Recovery in Acute Ischemic Stroke Patients Undergoing Thrombectomy [0.03%]
急性缺血性卒中取栓患者的脑体弱对临床表现和神经功能预后的影响
Joachim Fladt,Faysal Benali,Tanaporn Jaroenngarmsamer et al.
Joachim Fladt et al.
Background and objectives: Brain frailty impairs the ability to compensate for brain dysfunction and is linked to worse outcomes after stroke. Stroke severity at presentation is a key determinant of outcomes in acute isch...
Randomized Controlled Trial
Neurology. 2025 May 27;104(10):e213619. DOI:10.1212/WNL.0000000000213619 2025
Effect of Thrombolytics on Delayed Reperfusion After Incomplete Thrombectomy: Target Trial Emulation [0.03%]
溶栓对不完全取栓后的延迟再灌注的影响：靶向试验仿真研究
Adnan Mujanovic,Vignan Yogendrakumar,Felix C Ng et al.
Adnan Mujanovic et al.
Background and objectives: More than half of the endovascularly treated ischemic stroke patients with incomplete reperfusion (expanded Thrombolysis in Cerebral Infarction [eTICI]
Hillary Mullan
Hillary Mullan