Teaching NeuroImage: Tracing a 15-Year Trajectory of Radiation-Induced Leukoencephalopathy to Dementia [0.03%]
教学神经影像：放射性脑病致痴呆15年轨迹追踪
Marcelo Houat de Brito,Marcos C B Oliveira,Aline Sgnolf Ayres et al.
Marcelo Houat de Brito et al.
Transcription Factor Binding and Individual Genetic Risk of Valproate Teratogenicity [0.03%]
转录因子结合与丙戊酸致畸的个体遗传风险
Alison Anderson,Piero Perucca,Elena Vianca et al.
Alison Anderson et al.
Background and objectives: Valproate (VPA) use during pregnancy is associated with a wide range of structural birth defects, but not all exposed children are affected and there is evidence for a genetic predisposition. Th...
Treating Hearing Loss With Hearing Aids for the Prevention of Cognitive Decline and Dementia [0.03%]
助听器治疗听力损失预防认知衰退和痴呆
Lachlan Cribb,Margarita Moreno-Betancur,Matthew Paul Pase et al.
Lachlan Cribb et al.
Background and objectives: Hearing loss is a risk factor of cognitive decline and dementia. We sought to investigate the effect of hearing aid (HA) use on cognition and dementia risk in older adults with hearing impairmen...
Mina A Jacob,Frank-Erik de Leeuw
Mina A Jacob
Admission Systolic Blood Pressure and Outcomes After Endovascular Thrombectomy: An International EVA-TRISP Cohort Study [0.03%]
国际多中心EVA-TRISP队列研究：血管内血栓切除术后结局与术前血压的关系
Nabila Wali,Abris D Mumcuoglu,Sophie A Van Den Berg et al.
Nabila Wali et al.
Background and objectives: Current international guidelines recommend blood pressure (BP) thresholds for patients eligible for endovascular thrombectomy (EVT). Previous studies have suggested that both low and high admiss...
Observational Study
Neurology. 2026 Feb 10;106(3):e214530. DOI:10.1212/WNL.0000000000214530 2026
CSF α-Synuclein Seed Amplification Assays and Skin Immunofluorescence: Clinical Applications, Research Opportunities, and Knowledge Gaps [0.03%]
脑脊液α-突触核蛋白种子放大实验和皮肤免疫荧光：临床应用、研究机遇与知识空白
David G Coughlin,Charles H Adler,William Barbosa et al.
David G Coughlin et al.
The development of biomarkers capable of reliably detecting pathologic forms of α-synuclein (aSyn) in vivo marks a significant step forward in the field of neurodegeneration. Over the recent years, CSF aSyn seed amplification assays (aSyn-...
What Are the Roles of Mitochondrial Stress Responses and Mitohormesis in Neurodegenerative Disorders? [0.03%]
线粒体应激反应和米托霍瑞斯在神经退行性疾病中的作用是什么？
Eduardo Benarroch
Eduardo Benarroch
Mitochondrial dysfunction is a key pathogenic component of neurodegenerative disorders. Mitochondrial stress, created by accumulation of misfolded proteins, reactive oxygen species, and other mechanisms, triggers signals that promote change...
Development of a Prognostic Model for Poststroke Dementia Using Multiple International Cohorts: A STROKOG Collaboration Study [0.03%]
基于多个国际队列的卒中后痴呆预后模型的建立及验证——STROKOG合作研究
Jessica W Lo,John D Crawford,David W Desmond et al.
Jessica W Lo et al.
Background and objectives: Dementia risk prediction models developed for the general population perform poorly in stroke cohorts. Existing stroke-specific models are few and limited by short prediction horizons or relianc...
The Role of Academic Medical Centers in Personalized Experimental Therapeutic Development: Key Considerations [0.03%]
美国学术医学中心在个性化实验性治疗发展中的作用：关键考虑因素
Kira A Dies,Timothy W Yu,Nancy L Chamberlin et al.
Kira A Dies et al.
The recent rapid rise in the number of identified genetic disorders that are potentially treatable has far outpaced the development of treatments, resulting in a worsening bottleneck in the translational pipeline. New therapeutics that targ...