Mechanism-Based Therapy With Ampreloxetine for Neurogenic Orthostatic Hypotension in Multiple System Atrophy: A Randomized Withdrawal Trial [0.03%]
用于治疗多系统萎缩患者神经源性直立性低血压的胺洛利克汀机制-based疗法：一项随机撤药试验
Roy Freeman,Horacio Kaufmann,Italo Biaggioni et al.
Roy Freeman et al.
Background and objectives: Degeneration of the central autonomic network with relative sparing of peripheral autonomic neurons underlies neurogenic orthostatic hypotension in patients with multiple system atrophy (MSA). A...
Randomized Controlled Trial
Neurology. 2026 Aug 11;107(3):e218284. DOI:10.1212/WNL.0000000000218284 2026
Fracture Risk With Lacosamide vs Levetiracetam Monotherapy in Adults With Epilepsy [0.03%]
成人癫痫患者中拉考沙胺单药治疗的骨折风险高于levetiracetam单药治疗
Majd A AbuAlrob,Ali Al-Salahat,Rand Abdellatif et al.
Majd A AbuAlrob et al.
Objectives: Patients with epilepsy exhibit substantially elevated fracture risk. However, comparative skeletal safety data for newer antiseizure medications (ASMs) remain limited. The aim of this study was to compare frac...
Comparative Study
Neurology. 2026 Aug 11;107(3):e218269. DOI:10.1212/WNL.0000000000218269 2026
Lacosamide and Increased Fracture Risk: Need for More Study of Antiseizure Medications and Bone Health [0.03%]
拉科酰胺与骨折风险增加：抗癫痫药物和骨骼健康研究的必要性
Alison M Pack
Alison M Pack
Time to Treatment in Stroke Thrombectomy and Outcomes in the Extended Time Window: A Meta-Analysis [0.03%]
扩大时间窗内取栓治疗的再通时间和预后：一项荟萃分析
Raul G Nogueira,Tudor G Jovin,Maarten G Lansberg et al.
Raul G Nogueira et al.
Background and objectives: Time to endovascular thrombectomy (EVT) is a critical determinant of outcomes for large vessel occlusion (LVO) strokes presenting within 6 hours of onset. Its impact in the extended (6-24-hour) ...
Meta-Analysis
Neurology. 2026 Aug 11;107(3):e218113. DOI:10.1212/WNL.0000000000218113 2026
Is Time Independence in the Extended Time Window Thrombectomy an Illusion? [0.03%]
延长取栓时间窗的静脉溶栓是否存在假象？
Adi Shemesh,Aristeidis H Katsanos
Adi Shemesh
Comparison of the Efficacy and Safety of Myasthenia Gravis Treatments: A Bayesian Network Meta-Analysis [0.03%]
自身免疫性重症肌无力治疗疗效和安全性的贝叶斯网络 meta 分析
Nilay P McLaren,Matteo Rosati,Wayne Zhong et al.
Nilay P McLaren et al.
Background and objectives: In the past decade, several novel therapies have shown promise in treating generalized myasthenia gravis (MG); however, no head-to-head prospective studies have compared their efficacy and safet...
Comparative Study
Neurology. 2026 Aug 11;107(3):e218351. DOI:10.1212/WNL.0000000000218351 2026
Involvement of TNFRSF9 in the Pathogenesis of Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy [0.03%]
TNFRSF9在自身免疫性胶质纤维酸性蛋白星形细胞病发病机制中的作用
Akio Kimura,Akira Takekoshi,Yoichi Maekawa et al.
Akio Kimura et al.
Background and objectives: Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy (GFAP-A) is a CNS inflammatory disorder characterized by steroid responsiveness and relapse. Although GFAP immunoglobulin G (GFAP...
Observational Study
Neurology. 2026 Aug 11;107(3):e218306. DOI:10.1212/WNL.0000000000218306 2026
Joshua D Grill,Jonathan Graff-Radford
Joshua D Grill
Interventions to delay or prevent Alzheimer disease dementia hold the promise of sizable personal and public benefit. The nomenclature, research designs, and interpretation of results for studies assessing prevention outcomes, however, are ...
Rasch-Built Overall Disability Scale for Chronic Idiopathic Axonal Polyneuropathy [0.03%]
慢性特发性轴突多神经病的快速构建总体残疾量表
Gerjan M van der Star,Catharina G Faber,Pieter A van Doorn et al.
Gerjan M van der Star et al.
Background and objectives: Chronic idiopathic axonal polyneuropathy (CIAP) is a common type of chronic polyneuropathy that often affects health-related quality of life. Currently, no patient-reported disease-specific outc...
Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis After Initiation of Antiseizure Medication: A Danish Nationwide Cohort Study [0.03%]
抗癫痫药物治疗后发生史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症风险：一项丹麦全国队列研究
Ida M Heerfordt,Mette Mogensen,Anna Horwitz et al.
Ida M Heerfordt et al.
Background and objectives: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious cutaneous adverse reactions associated with several antiseizure medications, particularly lamotrigine and carbamaz...