Dual-Template Engineered Low-Tortuosity Hydrogels with Gradient Microchannels for On-Demand Management of Refractory Wounds [0.03%]
用于按需管理难治性伤口的双模板工程低扭曲水凝胶及其梯度微通道
Siyu Li,Jinying He,Lunhao Zhi et al.
Siyu Li et al.
Chronic refractory wounds present a significant clinical challenge due to the vicious cycle of excessive exudate and bacterial infections. Herein, we develop a smart hydrogel dressing via a dual-template strategy that creates a low-tortuosi...
Nanoparticle-Cross-Linked Smart Responsive Hydrogels for Antimicrobial, Anti-Inflammatory, and Antioxidant Treatment of Diabetic Wounds [0.03%]
用于糖尿病伤口抗菌、抗炎和抗氧化治疗的智能响应型纳米颗粒交联水凝胶
Junpeng Wang,Feijing Hao,Chengwei Xu et al.
Junpeng Wang et al.
Infected diabetic wounds are complicated by bacterial infection, oxidative stress, and hyperglycemia, limiting conventional monotherapies. Combination therapies suffer from uncontrolled release and poor responsiveness to pathological cues. ...
Nanoscale Structural Insights into Human Pulmonary Mucus and Its Snail Slime-Based Surrogate Using Automated TEM Image Processing [0.03%]
基于自动透射电镜图像处理的人肺黏液及其钉螺粘液模拟体系的纳米结构研究
Marine Le Goas,Florian Hinoveanu,Catherine Pioche-Durieu et al.
Marine Le Goas et al.
Pulmonary drug delivery is a promising approach for treating respiratory diseases, but the mucus barrier in bronchial airways often hinders therapeutic efficacy. The nanoscale structure of mucus is critical for drug penetration, yet remains...
Design of Experiment-Assisted Development of Biodegradable Chitosan/Whey Protein Isolate Films as Advanced Pro-Regenerative Wound Dressings [0.03%]
基于实验设计的可促进伤口再生的壳聚糖/乳清分离蛋白膜的研究与开发
Caterina Valentino,Barbara Vigani,Marco Ruggeri et al.
Caterina Valentino et al.
Chitosan (CS) and whey protein isolate (WPI) are promising biomacromolecules for wound healing; however, a rational understanding of how polymer-protein interactions influence the performance of wound dressings is still lacking. Herein, CS/...
Intrinsic Charge-Shielding Effects of Bacteria Promote Rapid On-Surface Assembly of Random-Coil Oligopeptides for Enhanced Antibacterial Activity [0.03%]
细菌的内在电荷屏蔽效应可促进无规线团寡肽在表面的快速组装以增强抗菌活性
Yi Cheng,Shuaishuai Nie,He Zhao et al.
Yi Cheng et al.
Bacteria-induced assembly of cationic oligopeptides via a charge shielding mechanism represents a promising strategy for improving the antibacterial capacity of oligopeptides. However, the impact of amino acid residues, sequence encoding, a...
Systematic Investigation of Reaction Parameters and Purification Strategies for DNA-Polymer Conjugates [0.03%]
DNA-聚合物共轭物反应参数及纯化策略的系统研究
Kevin J Coghlan,Carly Slough,Bridgette M Elder et al.
Kevin J Coghlan et al.
DNA-polymer conjugates are an emerging class of biohybrid materials with applications in therapeutics and biosensing, yet quantitative guidelines for optimizing conjugation conversion and purification remain unreported. Here, we systematica...
pH/ROS Dual-Responsive Zwitterionic Polymer Micelles with Enhanced Mucus Penetration for Bacterial Pneumonia Therapy [0.03%]
用于细菌性肺炎治疗的增强粘液穿透性的pH / ROS双响应两性离子聚合物胶束
Xue Yang,Menglin Huang,Hongjing Wu et al.
Xue Yang et al.
Bacterial pneumonia, a prevalent respiratory disease with high global morbidity and mortality rates, remains a formidable therapeutic challenge. Herein, pH/reactive oxygen species (ROS) dual-responsive zwitterionic polymer (PODEA-b-P(ROS-CA...
Injectable Thermoresponsive PIB/PDA/Doxycycline Hydrogels with Antibacterial, Antioxidant, and Temperature-Triggered Hemostatic Functions for Wound Healing [0.03%]
用于伤口愈合的抗菌、抗氧化和温度触发止血功能的可注射温敏型聚异丁烯/多巴胺/多西环素水凝胶
Yuanjing Zhang,Zheng Chen,Jiaxuan Guo et al.
Yuanjing Zhang et al.
Injectable and thermoresponsive hydrogels integrating hemostasis, infection suppression, and oxidative stress mitigation are highly desirable for complex wound management and intravascular intervention scenarios. Herein, we developed a bioc...
Nanodisc-Forming Polymers as TLR7/8 Agonist-Conjugated Immunotherapy Agents [0.03%]
TLR7/8激动剂结合免疫治疗剂的纳米盘聚合物载体
Neil J Borthwick,Ciara F Pugh,Kristoffer H Johansen et al.
Neil J Borthwick et al.
Amphiphilic polymers can solubilize membrane proteins in what is coined native lipid nanodiscs, although their potential as drug delivery platforms is mostly unexplored. Herein, we covalently attached a Toll-like receptor 7/8 agonist to pol...
Mechanism for Chemical Modification of 2-Hydroxypropyl-β-Cyclodextrin by Pulsed Plasma Irradiation of Liquid Flow [0.03%]
脉冲等离子体辐照流体诱导羟丙基-β-环糊精化学修饰的机理研究
Taishi Yamakawa,Camelia Miron,Kenichi Inoue et al.
Taishi Yamakawa et al.
The present work assessed the functionalization of 2-hydroxypropyl-β-cyclodextrin (HPβCD) using a nanosecond pulsed plasma treatment in the liquid phase, at atmospheric pressure, to generate a highly controllable nonequilibrium reaction f...