Preventative therapies for respiratory Syncytial virus (RSV) in children: Where are we now? [0.03%]
儿童呼吸道合胞病毒(RSV)的预防疗法现状如何？
Marie-Hélène Bourassa,Larry C Lands
Marie-Hélène Bourassa
Respiratory Syncytial Virus (RSV) is a leading cause of hospitalization in young children and represents a substantial health-care burden around the world. Advances in research have helped identify the prefusion F protein as the key target ...
Can postural changes in spirometry in children with Duchenne muscular dystrophy predict sleep hypoventilation? [0.03%]
姿势变化能预测杜氏肌营养不良儿童睡眠通气异常吗？
C Pandit,B Kennedy,K Waters et al.
C Pandit et al.
Aim: To explore the relationship between postural changes in lung function and polysomnography (PSG) in children with Duchenne muscular dystrophy (DMD). M...
Diagnostic challenges in CFTR-related metabolic syndrome: Where the guidelines fall short [0.03%]
囊性纤维化跨膜传导调节物功能相关代谢综合征的诊断挑战：指南不足之处
Erin F Kallam,Ajay S Kasi,Eileen Barr et al.
Erin F Kallam et al.
Newborn screening (NBS) for cystic fibrosis (CF) has enabled earlier diagnosis and has improved nutritional and growth-related outcomes in children with CF. For those with a positive NBS for CF that do not meet the diagnostic criteria for C...
A systematic review on the use of bacteriophage in treating Staphylococcus aureus and Pseudomonas aeruginosa infections in cystic fibrosis [0.03%]
噬菌体在治疗囊性纤维化患者金黄色葡萄球菌及绿脓杆菌感染中的应用系统评价
Jagdev Singh,Eugene Yeoh,Dominic A Fitzgerald et al.
Jagdev Singh et al.
Respiratory infections caused by Staphylococcus aureus and Pseudomonas aeruginosa are a major concern for cystic fibrosis (CF) patients due to increasing antibiotic resistance. Bacteriophages, which are viruses that selectively target and k...
Unintended impacts of COVID-19 on the epidemiology and burden of paediatric respiratory infections [0.03%]
新冠肺炎疫情对儿童呼吸道感染流行病学和疾病负担的间接影响
Rebecca Burrell,Gemma Saravanos,Philip N Britton
Rebecca Burrell
Acute respiratory infections (ARI), especially lower respiratory infections (LRI), are a leading cause of childhood morbidity and mortality globally. Non-pharmaceutical interventions (NPI) employed during the COVID-19 pandemic have impacted...
Evaluation of the therapeutic efficacy and tolerability of current drug treatments on the clinical outcomes of paediatric spinal muscular atrophy type 1: A systematic review [0.03%]
系统综述：当前药物治疗方案对儿童脊髓性肌萎缩症Ⅰ型临床转归疗效和耐受性的评估
Anmar Al-Taie,Aygül Köseoğlu
Anmar Al-Taie
Spinal muscular atrophy (SMA) is a severe hereditary lower motor neuron disorder characterised by degeneration of alpha motor neurons in the spinal cord, resulting in progressive weakness and paralysis of proximal muscles. A systematic lite...
Variable and evolving degrees of CFTR dysfunction: Implications for diagnosis and clinical management [0.03%]
CTFR功能障碍的可变性和演变性：对诊断和临床治疗的影响
A Shawcross,J C Davies,R Pabary
A Shawcross
Cystic fibrosis to CFSPID: Burden of care vs need and rational approach to weaning therapies [0.03%]
从囊性纤维化到CFSPID：护理负担与需求的理性治疗方案调整方法
S Hadjisymeou Andreou,J C Davies
S Hadjisymeou Andreou
We present a case of a 10-year-old boy initially diagnosed with CF based on NBS guidelines. However, as CF genetics knowledge has advanced, he has been reclassified as CFSPID based on normal investigations and excellent general clinical sta...
Exposure to residential mold and dampness and the associations with respiratory tract infections and symptoms thereof in children in high income countries: A systematic review and meta-analyses of epidemiological studies [0.03%]
高收入国家儿童家中霉菌和潮湿暴露与呼吸道感染及症状关系的系统评价和meta分析
Jonathan Groot,Emilie Tange Nielsen,Trine Fuhr Nielsen et al.
Jonathan Groot et al.
Background: Multiple reviews have been conducted on the associations between residential mold and dampness and respiratory outcomes in children, with few specifically investigating respiratory tract infections (RTIs). ...
An innovative strategy for personalised medicine in a CFSPID case that evolved with time [0.03%]
时间变化的CFSPID病例个性化医疗的创新策略
J Twynam-Perkins,A Fall,J W Lefferts et al.
J Twynam-Perkins et al.
We present a challenging case that illustrates how the clinical manifestations in children with CFTR mutations of uncertain significance may change over time. This case highlights the evolution of confirming a diagnosis of CF and emphasises...