Dexmedetomidine improves septic acute kidney injury by inhibiting inflammation and oxidative stress through the activation of the Pink1/Park2 autophagy pathway [0.03%]
右美托咪啶通过激活Pink1/Parkin自噬途径抑制炎症和氧化应激来改善脓毒症急性肾损伤
Qiuxia Liao,Zhi Feng,Hairong Lin et al.
Qiuxia Liao et al.
Impaired autophagy is a key factor in the development of septic acute kidney injury (SAKI). Dexmedetomidine-an α2 adrenergic agonist widely used as a sedative-exerts protective effects in SAKI. However, its correlation with autophagy remai...
The impact of Naples prognostic score on cognitive impairment in hemodialysis patients: a multicenter study [0.03%]
那不勒斯预后评分对透析患者认知功能损伤的影响及多中心研究
Yan Ran,Yuqi Yang,Yanzhe Peng et al.
Yan Ran et al.
Background: Malnutrition and inflammation are prevalent in hemodialysis (HD) patients and linked to cognitive impairment (CI). Naples prognostic score (NPS) is a comprehensive measure of patients' inflammation and nutriti...
Multicenter Study
Renal failure. 2025 Dec;47(1):2515531. DOI:10.1080/0886022X.2025.2515531 2025
Development of a convenient and rapid screening zebrafish model to investigate lethal effects and immunocompromised states of uremic toxins [0.03%]
一种方便快捷的用于研究尿毒症毒素致死效应和免疫抑制状态的斑马鱼模型的发展
Pema Jo,Rui Zhang,Yuhua Zhang et al.
Pema Jo et al.
Background: Uremia is characterized by high mortality and immune dysfunction owing to the accumulation of uremic toxins. Traditional rodent models are complex and time consuming. This study aimed to develop a simple and r...
Healthy Eating Index-2015, a protective factor for mitochondria-derived methylmalonic acid in the low poverty/income ratio with chronic kidney diseases: results from NHANES 2011-2014 [0.03%]
健康饮食指数-2015对低贫困/收入比的慢性肾脏疾病的线粒体衍生型甲基丙二酸具有保护作用：NHANES 2011-2014的结果
Yunfei Xiao,Yaqing Yang,Hao Zhang et al.
Yunfei Xiao et al.
Objective: Serum methylmalonic acid (MMA) arises from impaired metabolism of methylmalonyl-CoA and is exacerbated in chronic kidney disease (CKD) due to reduced renal clearance and nutritional deficiencies. The quality of...
Clinicopathological and prognostic study of idiopathic membranous nephropathy with tip or non-tip variant focal segmental glomerulosclerosis: a single-center cohort study [0.03%]
以单中心队列研究的免疫病理和平预后为中心的特发性膜性肾病伴有指状或非指状变异性局灶节段性肾小球硬化症的研究
Shungang Xu,Xueting Liu,Xuanwen Chen et al.
Shungang Xu et al.
Idiopathic membranous nephropathy (IMN) complicated with focal segmental glomerulosclerosis (FSGS) is not rare, but the impact of variant pathological manifestations of FSGS (tip variant vs non-tip variant) on the clinical and prognosis of ...
Global burden and epidemic trends of chronic kidney disease attributable to high body mass index: insights from the Global Burden of Disease Study 2021 [0.03%]
基于全球疾病负担研究2021的高体重指数所致慢性肾脏病的疾病负担和流行趋势分析
Zehui Rao,Kaihong Wang,Kun Zhou et al.
Zehui Rao et al.
Background: High body mass index (BMI) is associated with an increased risk of chronic kidney disease (CKD). However, studies on the CKD burden due to high BMI are limited. ...
Inhibition of matrix metalloproteinase-9 attenuates kidney fibrosis and cellular senescence in the transition from acute kidney injury to chronic kidney disease [0.03%]
金属基质金属蛋白酶-9抑制剂可减轻急性肾损伤向慢性肾脏病转变过程中的肾纤维化和细胞衰老现象
Daoqi Shen,Liyu Lin,Yiqi Su et al.
Daoqi Shen et al.
Background: The mechanisms underlying the progression of chronic kidney disease (CKD) following acute kidney injury (AKI) remain poorly understood. Senescent cells induce maladaptive repair have been identified as a signi...
Alpha-1-microglobulin profile in patients on maintenance hemodialysis and its removal by blood purification [0.03%]
维持性血液透析患者血清α1微球蛋白谱及其清除率
Tadashi Tomo,Kazuhiro Matsuyama,Katsuhiro Hanada et al.
Tadashi Tomo et al.
Alpha-1-microglobulin (A1M), metabolized in renal tubules, plays an important role as a potent antioxidant in human cells. The majority of A1M is present in the blood in free form and in a bound form with IgA dimers, with the free form thou...
Rongrong Tian,Liyang Chang,Linghong Cheng et al.
Rongrong Tian et al.
Background: Malnutrition, inflammation, and fluid overload can reinforce each other, forming a detrimental syndrome in patients receiving hemodialysis (HD). However, this syndrome remains insufficiently recognized. This s...
Non-linear associations between serum manganese with chronic kidney disease: results from two nationwide studies in the United States and China [0.03%]
血清锰与慢性肾脏病之间非线性关联：美国和中国两项全国性研究结果
Jiliang Zhang,Yimei Wang,Shi Jin et al.
Jiliang Zhang et al.
Introduction: This study aimed to better evaluate the association between serum manganese (Mn) and chronic kidney disease (CKD) by using data from the United States National Health and Nutrition Examination Survey (NHANES...