Emerging role and the signaling pathways of uncoupling protein 2 in kidney diseases [0.03%]
线粒体_uncoupling_protein_2在肾脏疾病中的作用及信号转导机制研究进展
Song Mao
Song Mao
Objectives: Uncoupling protein 2 (UCP2) was involved in the pathogenesis and development of kidney diseases. Many signaling pathways and factors regulate the expression of UCP2. We aimed to investigate the precise role of...
M2 macrophage infusion ameliorates diabetic glomerulopathy via the JAK2/STAT3 pathway in db/db mice [0.03%]
M2型巨噬细胞移植通过JAK2/STAT3信号途径改善小鼠糖尿病肾病病理损害
Yulin Gu,Songyan Yu,Weijun Gu et al.
Yulin Gu et al.
Objectives: To explore the therapeutic effects of M2 macrophages in diabetic nephropathy (DN) and their mechanism.Methods: We infused M2 macrophages stimulated with IL-4 into 10-week-old db/db mice once a week for 4 weeks through the tail v...
Predictive models of sepsis-associated acute kidney injury based on machine learning: a scoping review [0.03%]
基于机器学习的脓毒症相关急性肾损伤预测模型的系统评价性回顾研究
Jie Li,Manli Zhu,Li Yan
Jie Li
Background: With the development of artificial intelligence, the application of machine learning to develop predictive models for sepsis-associated acute kidney injury has made potential breakthroughs in early identificat...
Causal effect of lipoprotein(a) level on chronic kidney disease of European ancestry: a two-sample Mendelian randomization study [0.03%]
载脂蛋白(a)水平对欧洲血统慢性肾脏病影响的因果效应：两样本孟德尔随机化研究
Yunhui Zhu,Songzan Chen,Zhebin Chen et al.
Yunhui Zhu et al.
Introduction: Chronic kidney disease is a growing health issue, and the options of prevention and therapy remain limited. Although a number of observational studies have linked higher Lp(a) [lipoprotein(a)] levels to the ...
Astragaloside IV relieves passive heymann nephritis and podocyte injury by suppressing the TRAF6/NF-κb axis [0.03%]
Astragaloside IV通过抑制TRAF6/NF-κb轴缓解被动Heymann肾炎和足细胞损伤
Yuhua Ma,Yuwen Hu,Yilin Ruan et al.
Yuhua Ma et al.
The pathogenesis of membranous nephropathy (MN) involves podocyte injury that is attributed to inflammatory responses induced by local immune deposits. Astragaloside IV (AS-IV) is known for its robust anti-inflammatory properties. Here, we ...
Pressure induces peritoneal fibrosis and inflammation through CD44 signaling [0.03%]
压力通过CD44信号诱发腹膜纤维化和炎症
Yu-Wei Chen,Chia-Te Liao,Mei-Yi Wu et al.
Yu-Wei Chen et al.
Peritoneal dialysis (PD) is a widely used sustainable kidney replacement therapy. Prolonged use of PD fluids is associated with mesothelial-mesenchymal transition, peritoneal fibrosis, and eventual ultrafiltration (UF) failure. However, the...
Serum angiopoietin-2/angiopoietin-1 ratio is associated with cardiovascular and all-cause mortality in peritoneal dialysis patients: a prospective cohort study [0.03%]
血清血管生成素-2/血管生成素-1比率与腹膜透析患者的全因死亡率和心血管死亡率相关：一项前瞻性队列研究
Han Li,Qianhui Song,Xinyu Su et al.
Han Li et al.
Introduction: Our objective was to examine the factors associated with the serum angiopoietin-2/angiopoietin-1 (Angpt-2/Angpt-1) ratio in peritoneal dialysis (PD) patients and to investigate the association between Angpt-...
Acute kidney injury in hospitalized children in 20 hospitals of China's Hunan Province: a cross-sectional survey [0.03%]
中国湖南省20家医院住院儿童急性肾损伤的横断面调查研究
Qianliang Sun,Ying Pan,Zhihui Li
Qianliang Sun
Objective: The incidence of acute kidney injury (AKI) in pediatric patients has been increasing over the years, and AKI significantly impacts children's health and quality of life. This article reviews the current epidemi...
Multicenter Study
Renal failure. 2024 Dec;46(2):2379003. DOI:10.1080/0886022X.2024.2379003 2024
Graft survival after percutaneous transluminal renal stenting for transplant renal artery stenosis (TRAS) is worse compared to matched cadaveric grafts without TRAS [0.03%]
与无移植肾动脉狭窄的尸体供者相比，经皮透腔移植肾动脉成形术后的移植物存活率较低
Long Zhang,Jilin Zou,Jiangqiao Zhou et al.
Long Zhang et al.
Objectives: Transplant renal artery stenosis (TRAS) is now recognized as a curable disease with a good prognosis if intervention occurs in the early stage. However, the mid-term outcomes of TRAS when treated by percutaneo...
Comparative Study
Renal failure. 2024 Dec;46(2):2378211. DOI:10.1080/0886022X.2024.2378211 2024
Sirt6 overexpression relieves ferroptosis and delays the progression of diabetic nephropathy via Nrf2/GPX4 pathway [0.03%]
长寿蛋白Sirt6通过Nrf2/GPX4信号通路缓解糖尿病肾病铁死亡的机制研究
Lingyu Du,Canghui Guo,Shengnan Zeng et al.
Lingyu Du et al.
Objective: Sirt6, reactive oxygen species and ferroptosis may participate in the pathogenesis of Diabetic Nephropathy (DN). Exploring the relationship between Sirt6, oxidative stress, and ferroptosis provides new scientif...