Multimodal ultrasound deep learning to detect fibrosis in early chronic kidney disease [0.03%]
用于早期慢性肾脏病纤维化检测的多模态超声影像深度学习方法研究
Xiachuan Qin,Xiaoling Liu,Linlin Xia et al.
Xiachuan Qin et al.
We developed a multimodal ultrasound (US) deep learning (DL) fusion model to automatically classify early fibrosis in patients with chronic kidney disease (CKD). This prospective study included patients with CKD who underwent continuous gra...
Development and validation of a chronic kidney disease progression model using patient-level simulations [0.03%]
基于以患者为对象的模拟的慢性肾病进展模型的构建和验证
Mafalda Ramos,Laetitia Gerlier,Anastasia Uster et al.
Mafalda Ramos et al.
Chronic disease progression models are available for several highly prevalent conditions. For chronic kidney disease (CKD), the scope of existing progression models is limited to the risk of kidney failure and major cardiovascular (CV) even...
Circulating RAC1 contributed to steroid-sensitive nephrotic syndrome: Mendelian randomization, single-cell RNA-sequencing, proteomic, and experimental evidence [0.03%]
循环中的RAC1参与糖皮质激素敏感型肾病综合征：孟德尔随机化、单细胞RNA测序、蛋白质组学和实验证据
Yi Zhang,Tianwen Yao,Yanqiu Xu et al.
Yi Zhang et al.
Objectives: The small GTPase Rac1 (RAC1) has been linked to podocyte disorders and steroid-sensitive nephrotic syndrome (SSNS). The aim of this study was to explore and validate the potential causal association between ci...
Acute kidney disease in mice is associated with early cardiovascular dysfunction [0.03%]
急性肾病小鼠的心血管功能障碍症状提早出现
Pauline Caillard,Youssef Bennis,Cédric Boudot et al.
Pauline Caillard et al.
Acute kidney injury (AKI) and chronic kidney disease (CKD) are major health concerns due to their increasing incidence and high mortality. They are interconnected syndromes; AKI without recovery evolves into acute kidney disease (AKD), whic...
Effectiveness of tolvaptan on renal replacement therapy in patients with autosomal dominant polycystic kidney disease: a retrospective cohort study from the TriNetX global collaborative network [0.03%]
托伐普坦对常染色体显性多囊肾病患者肾脏替代治疗有效性的研究：来自TriNetX全球协作网络的回顾性队列研究
Ming-Ju Wu,Cheng-Hsu Chen,Shang-Feng Tsai
Ming-Ju Wu
Background and hypothesis: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a major genetic contributor to end-stage kidney disease (ESKD). Current evidence on tolvaptan primarily focuses on slowing estimated glome...
Sulforaphane regulates AngII-induced podocyte oxidative stress injury through the Nrf2-Keap1/ho-1/ROS pathway [0.03%]
萝卜硫素通过Nrf2-Keap1/HO-1/ROS信号通路调节血管紧张素AII诱导的podocytes氧化应激损伤
Wen Lu
Wen Lu
Objective: This study aimed to investigate the therapeutic effects of sulforaphane and the role of the Nrf2-Keap1/HO-1/ROS pathway in AngII-induced oxidative stress in podocyte injury. ...
HDAC6 promotes inflammation in lupus nephritis mice by regulating transcription factors MAFF and KLF5 in renal fibrosis [0.03%]
HDAC6通过调节肾脏纤维化中的转录因子MAFF和KLF5促进狼疮性肾炎小鼠的炎症
Meihui Deng,Xiao Tan,Xiaojie Peng et al.
Meihui Deng et al.
Aim: This study explored the effect and mechanism of MAFF and HDAC6 on renal fibrosis and inflammation in lupus nephritis (LN). Methods: ...
Association between dietary fiber intake and chronic kidney disease in adults with and without hypertension in the United States: a cross-sectional study of NHANES 2009-2020 [0.03%]
2009年至2020年美国成年人膳食纤维摄入与慢性肾脏病的关联：基于NHANES的横断面研究
Chao Zhang,Weimin Yan,Xun Sun et al.
Chao Zhang et al.
While previous research has highlighted the potential advantages of increasing dietary fiber intake (DFI) for managing hypertension and chronic kidney disease (CKD), there is a gap in large-scale empirical studies examining the relationship...
Factors associated with dysfunction of autogenous arteriovenous fistula in patients with secondary hyperparathyroidism after parathyroidectomy [0.03%]
继甲状旁腺切除术后终末期肾病患者 Secondary HPT 对动静脉内瘘功能障碍的影响
Boxi Chen,Qiying Fang,Yiming Tao et al.
Boxi Chen et al.
Background: Secondary hyperparathyroidism (SHPT) is a prevalent chronic complication in patients undergoing hemodialysis. Parathyroidectomy (PTX) is crucial for reducing mortality and improving the prognosis in the treatm...
Cumulative rabbit anti-human thymocyte globulin dose to recipient weight during the peri-operative period is an independent risk factor for early postoperative urinary tract infection after kidney transplantation [0.03%]
术前术后兔抗人胸腺免疫球蛋白累积剂量与受者体重的比值为肾脏移植后早期泌尿系统感染的独立危险因素
Shujuan Li,Ziyu Wang,Zhen Dong et al.
Shujuan Li et al.
Anti-human thymocyte globulin-Fresenius (ATG-F) is frequently utilized to achieve successful induction for kidney transplantation recipients. This study aimed to examine the association between the ATG-F dose-to-recipient-weight ratio (ADR)...