Immunometabolic transcriptomic signatures of diabetes-related genes predict kidney transplant rejection [0.03%]
与糖尿病相关的免疫代谢转录组特征可预测肾脏移植排斥反应
Roberto Casale,Andrea Dello Strologo,Carlo Alfieri et al.
Roberto Casale et al.
Objectives: Kidney transplantation remains the gold standard for end-stage renal disease, yet long-term graft survival is limited by acute and chronic rejection. Emerging evidence highlights the critical role of immunomet...
SGLT2 inhibitors preserve serum chloride in non-diabetic CKD: a propensity-matched and LASSO regression analysis [0.03%]
钠-葡萄糖协同转运蛋白2抑制剂可保留非糖尿病CKD患者的血清氯:倾向匹配和LASSO回归分析
Masaru Matsui,Takaaki Kosugi,Shunsuke Kitamura et al.
Masaru Matsui et al.
Sodium-glucose cotransporter 2 inhibitors (SGLT2is) are novel renoprotective agents for patients with chronic kidney disease (CKD) and have diverse effects, including on the regulation of electrolyte balance. However, their effects on serum...
Risk prediction in IgA nephropathy: from conventional models to machine learning, deep learning, and precision nephrology [0.03%]
IgA肾病的风险预测：从传统模型到机器学习、深度学习和精准肾病学
Han Xu,Shuwang Ge
Han Xu
IgA nephropathy (IgAN) is the most prevalent primary glomerular disease worldwide and a leading cause of end-stage kidney disease (ESKD). Its clinical heterogeneity results in divergent renal outcomes, making early identification of high-ri...
Flow-driven left ventricular remodelling in long-term haemodialysis: a multicenter model of arteriovenous access-induced cardiac load [0.03%]
血液透析患者的左心室重建模型：动静脉通路诱导的心脏负荷所致
Naoko Kyoda,Rika Ago,Shingo Fukuma et al.
Naoko Kyoda et al.
Background: Arteriovenous (AV) access, an essential component of dialysis treatment, has been implicated in the development of cardiovascular abnormalities. However, whether AV access blood flow and the duration of exposu...
Multicenter Study
Renal failure. 2026 Dec;48(1):2622136. DOI:10.1080/0886022X.2026.2622136 2026
Cardiorenal protective effects of glucagon-like peptide-1 receptor agonists in chronic kidney disease: a systematic review and meta-analysis [0.03%]
胰高血糖素样肽-1受体激动剂在慢性肾脏病中的心肾保护作用：系统评价和meta分析
Yuqi Wang,Luda Feng,Yajing Wang et al.
Yuqi Wang et al.
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are widely used in patients with chronic kidney disease (CKD), but existing evidence regarding their efficacy and safety remains inconsistent. To evaluate the cardiorenal outcomes and ad...
The peritoneum in perspective: extracellular vesicles and the future of peritoneal dialysis [0.03%]
从整体出发看待腹膜：细胞外囊泡与透析的未来方向
Natalia Stepanova
Natalia Stepanova
Peritoneal dialysis (PD) transforms the peritoneum into a dynamic therapeutic interface, with each exchange offering direct access to molecular and cellular signals from the peritoneal cavity. Among these, extracellular vesicles (EVs) have ...
Association between the preoperative serum albumin-to-creatinine ratio (sACR) and in-hospital mortality in perioperative patients with chronic kidney disease: a cohort study based on INSPIRE database [0.03%]
基于INSPIRE数据库的围手术期慢性肾脏病患者术前血清白蛋白肌酐比值(sACR)与院内死亡率相关性的一项队列研究
Bin Pan,Bingwen Lin,Xiurong Huang et al.
Bin Pan et al.
Objective: The serum albumin-to-creatinine ratio (sACR) is a potential biomarker for multiple diseases, yet its prognostic role in chronic kidney disease (CKD) patients undergoing surgery remains unexplored. This study aimed to investigate ...
Targeting mitochondrial quality control in diabetic kidney disease: emerging therapeutic opportunities [0.03%]
靶向糖尿病肾脏病中的线粒体质量控制：新兴的治疗机会
Jiajun Luo,Fuer Lu,Magdalena Cuciureanu et al.
Jiajun Luo et al.
Diabetic kidney disease (DKD) is one of the most common microvascular complications among individuals with diabetes and has become a leading cause of end-stage renal disease (ESRD). The mechanisms underlying DKD are complex, and effective t...
Efficacy and safety of prolyl hydroxylase inhibitors for anemia in chronic kidney disease: a network meta-analysis [0.03%]
促羟基酶抑制剂治疗慢性肾脏病贫血的有效性和安全性：网状meta分析研究
Yuanchen Niu,Tenghua Wang,Yaoxuan Zhan et al.
Yuanchen Niu et al.
This Bayesian network meta-analysis evaluated the efficacy and safety of six prolyl hydroxylase inhibitors (PHIs) versus erythropoiesis-stimulating agents (ESAs) or placebo for chronic kidney disease (CKD) anemia. Electronic databases were ...
Single-cell transcriptomics and machine-learning reveal M1 macrophage-driven progression from minimal change disease to focal segmental glomerulosclerosis [0.03%]
单细胞转录组和机器学习揭示M1巨噬细胞驱动的从微小病变病到局灶节段性肾小球硬化的发展过程
Ting-Ting Wang,Hong Lu,Tong Shen et al.
Ting-Ting Wang et al.
Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are two key nephrotic syndrome types with significant clinical implications. MCD predominantly affects children, while FSGS is more common in adults, often leading t...