Causal relationship between chronic kidney disease, renal function, and venous thromboembolism: a bidirectional Mendelian randomization study [0.03%]
慢性肾脏病、肾功能和静脉血栓栓塞之间的因果关系：一项双向孟德尔随机化研究
Rongping Yang,Shuanglan Xu,Qian Liu et al.
Rongping Yang et al.
Background: Chronic kidney disease (CKD) and impaired renal function have been implicated in venous thromboembolism (VTE), but their causal relationships remain uncertain. This study employs Mendelian randomization (MR) t...
Stress hyperglycemia ratio as a predictor of acute kidney injury and its outcomes in critically ill patients [0.03%]
应激性高血糖比值在危重症急性肾损伤及其结局中的预测价值
Yingxin Lin,Sheng Zhang,Zeling Chen et al.
Yingxin Lin et al.
This study investigated stress hyperglycemia ratio (SHR) for acute kidney injury (AKI) and clinical outcomes in intensive care unit (ICU). Key outcomes were AKI within 48 h after ICU admission, acute kidney disease (AKD), ICU mortality, 28-...
Bidirectional Mendelian Randomization analysis of iron status and uremia: no evidence of a causal relationship [0.03%]
铁状态和尿毒症的双向孟德尔随机化分析：没有因果关系的证据
Jianwei Chen,Hu Zhao,Yang He et al.
Jianwei Chen et al.
Iron status and uremia have been linked, but the causality remains ambiguous. This bidirectional study aimed to explore the causal association between genetically predicted iron status and uremia. Utilizing summary data from genome-wide ass...
Causal associations between circulating metabolites and chronic kidney disease: a Mendelian randomization study [0.03%]
循环代谢产物与慢性肾脏病的因果关联：一项孟德尔随机化研究
Jie He,Lin Li,Hongjie Hu
Jie He
Background: Circulating metabolites have been associated with cross-sectional renal function in population-based research. Nevertheless, there is currently little proof to support the idea that metabolites either cause or...
Association between the difference in estimated GFR based on cystatin C versus creatinine in coronary artery diseases [0.03%]
胱抑素C与肌酐估算的肾小球滤过率在冠心病中的差异及相关性分析
Zechen Liu,Wangying Jiang,Yanjun Song et al.
Zechen Liu et al.
Background: The difference in estimated glomerular filtration rate (eGFR) derived from creatinine and cystatin C (eGFRdiff) has been noticed recently and the relationship with poor cardiovascular prognosis has been proven...
Comparative Study
Renal failure. 2025 Dec;47(1):2482127. DOI:10.1080/0886022X.2025.2482127 2025
Metformin and risk factors for chronic kidney disease in a European population based on Mendelian randomization [0.03%]
基于孟德尔随机化的欧洲人群二甲双胍与慢性肾脏病风险因素的关系研究
Xiaopei Liu,Xingyao Li,Peng An et al.
Xiaopei Liu et al.
Background: Metformin, widely used for type 2 diabetes, raises concerns about its use in chronic kidney disease (CKD) due to risks like lactic acidosis and renal function impact. This study uses Mendelian randomization (M...
The critical role of ion channels in kidney disease: perspective from AKI and CKD [0.03%]
离子通道在肾脏疾病中的关键作用：从急性肾损伤和慢性肾脏病角度的视角
Chen Sui Zi Li,Bing Yu,Qian Gao et al.
Chen Sui Zi Li et al.
Ion channels, particularly those in the transient receptor potential (TRP) family, play key roles in cellular stress responses like inflammation and apoptosis, significantly impacting renal disease progression. Some channels such as TRPV1, ...
Factors influencing early renal function changes after SGLT2 inhibitors use and its long-term prognosis: a real-world retrospective study [0.03%]
SGLT2抑制剂使用后早期肾功能变化的影响因素及其长期预后的实证研究
Bing Xie,Nan Ye,Guoqin Wang et al.
Bing Xie et al.
Background: The renal protective effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been confirmed. However, SGLT2i may lead to an increase in serum creatine shortly after administration. This study explor...
Association between lipid-lowering drug targets and the risk of cystic kidney disease: a drug-target Mendelian randomization analysis [0.03%]
降脂药靶点与囊性肾病风险之间的关联：一种药物-靶点孟德尔随机化分析
Zhiwen Lian,Zijie Liang,Qiyan Chen et al.
Zhiwen Lian et al.
Background: Evidence regarding the causal relationship between lipid-lowering drugs and cystic kidney disease, including polycystic kidney disease (PKD), was limited. This study aimed to evaluate the causal relationship b...
Association of insulin resistance indices with kidney stones and their recurrence in a non-diabetic population: an analysis based on NHANES data from 2007-2018 [0.03%]
基于2007年至2018年NHANES数据的非糖尿病人群胰岛素抵抗指数与肾结石及其复发关联性分析
Yu-Xuan Yang,Jia-Cheng Xiang,Gui-Chen Ye et al.
Yu-Xuan Yang et al.
Objective: To systematically evaluate the association between insulin resistance indices and the risk of kidney stones and their recurrence in U.S. non-diabetic individuals, while identifying predictive indicators. ...