Physcion alleviates cisplatin-induced apo in HK-2 cells by activating the apo signaling for treating acute kidney injury: Integrating network pharmacology and informatics [0.03%]
网络药理学和信息学整合表明毛花苷通过激活细胞凋亡信号途径缓解物理小体诱导的HK-2细胞凋亡以治疗急性肾损伤
Wanyao Yan,Fang Zhou,Gailing Li et al.
Wanyao Yan et al.
This research leverages the traditional Chinese medicine systems pharmacology (TCMSP) and Encyclopedia of traditional Chinese medicine (ETCM) to identify Chinese herbal remedies for (AKI) treatment. Lycii Fructus was found to be a potential...
Protective effects of glycine against diclofenac-induced toxicity in isolated rat hepatocytes [0.03%]
甘氨酸对 diclofenac 引起的大鼠肝细胞毒性的保护作用
Mostafa G Elkot,Hisham A Nematalla,Ihab T Abdel-Raheem et al.
Mostafa G Elkot et al.
Diclofenac (DIC) is a common cyclo-oxygenase inhibitor that has been linked to liver toxicity. Alternatively, glycine (GLY) has several beneficial actions, including direct cytoprotective, anti-inflammatory, anti-apoptotic, and antioxidant ...
Correction [0.03%]
改正
Published Erratum
Drug and chemical toxicology. 2025 Sep 18:1. DOI:10.1080/01480545.2025.2548103 2025
Oxidative stress and toxicity induced by copper and zinc oxide nanoparticles in liver and kidney tissues of male mice [0.03%]
铜和氧化锌纳米粒子对雄性小鼠肝肾组织氧化应激和毒性的诱导作用研究
Özge Temiz,Ferit Kargin,Hikmet Cogun et al.
Özge Temiz et al.
Copper and Zinc Oxide Nanoparticles are widely used in pharmacy, cosmetics, agriculture and engineering fields according to their chemical and biological properties; their toxic effects on living systems up to the environment and humans are...
Impact of benzophenone-2 exposure on the reproductive outcomes in adult female mice [0.03%]
苯二酚-2对成年雌性小鼠生殖结果的影响
Ahmed Lasaneya,Jogen Chandra Kalita
Ahmed Lasaneya
Benzophenone-2 (BP2) is considered a potential endocrine disruptor, but due to limited data availability, its specific impact on reproductive function is not fully understood. The current study investigated the in vivo toxic effect of BP2 i...
Biological effects of epoxy resins on the human body: toxicity and allergic reactions [0.03%]
环氧树脂对人类身体的生物效应：毒性与过敏反应
Maria Zofia Lisiecka
Maria Zofia Lisiecka
This research focused on assessing the impact of epoxy resin components on human health and formulating measures to mitigate their adverse effects. The investigation highlighted the primary routes of exposure to toxic substances, including ...
Obesity aggravates neurotoxicity of bisphenol A in female rats via endoplasmic reticulum stress mediated death signals [0.03%]
肥胖通过内质网介导的毒性加剧双酚A的神经毒性作用
Anuradha Mangla,Mehjbeen Javed,Poonam Goswami et al.
Anuradha Mangla et al.
Obesity is a chronic and multifactorial disease, in which activation of endoplasmic reticulum (ER) stress and resulting cell death have been widely implicated leading to the emergence of neurological diseases. Misfolded or unfolded proteins...
Glyphosate in the Iberian Peninsula: Evaluating risks to Iberian wildlife [0.03%]
Glyphosate在伊比利亚半岛：评估对伊比利亚野生动物的风险
Catarina Jota Baptista,Gonçalo Nogueira Marques,Luísa Lima Gonçalves et al.
Catarina Jota Baptista et al.
Glyphosate [N-(phosphonomethyl)glycine] (GlyP) is an herbicide extensively used worldwide, including the Iberian Peninsula. It is mainly used in agricultural landscapes but also in urban areas, in railways, and even in water bodies. Despite...
Expression of telomere length and shelterin genes in men and women leukocytes and their correlations with lipid peroxidation in sulfur mustard gas intoxication [0.03%]
硫芥气体中毒男性和女性外周血中端粒长度及 Shelterin 家族基因表达及其与脂质过氧化的关系
Leila Nasiri,Mohammad-Reza Vaez-Mahdavi,Tooba Ghazanfari et al.
Leila Nasiri et al.
Sulfur mustard (SM), a chemical warfare agent, inflicts severe acute and chronic health effects. This study investigates the impact of SM-induced oxidative stress on telomere length (TL) and shelterin gene expression, which are crucial for ...
Metabolomic insights into rotenone-induced dysregulation of purine metabolism and impaired insulin secretion in murine pancreatic beta cells [0.03%]
罗特曼诱导的小鼠胰岛β细胞嘌呤代谢失调和胰岛素分泌障碍的代谢组学研究见解
Surachai Ngamratanapaiboon,Pracha Yambangyang,Phichanan Duchda et al.
Surachai Ngamratanapaiboon et al.
Rotenone, an insecticide, and herbicide has been associated with various environmental and health concerns. This study investigates the molecular alterations in rotenone-treated murine pancreatic beta cells, using untargeted metabolomics ba...