N-acetyl cysteine and vitamin E attenuate acrylamide-induced hepatotoxicity via regulation of miRNA-34a and P53/Nrf2/SIRT 1 signaling pathways [0.03%]
N-乙酰半胱氨酸和维生素E通过调节miRNA-34a和P53/Nrf2/SIRT1信号通路缓解丙烯酰胺致肝毒性
Fatma A Gad,Mahmoud Abdelghaffar Emam,Abeer A Abdelhameed et al.
Fatma A Gad et al.
The present study is aimed to evaluate the hepatoprotective role of N-acetyl cysteine (NAC) and vitamin E (VE), as potent antioxidants, against acrylamide (ACR)-induced hepatotoxicity via investigation of alterations in miRNA-34a, P53, Nrf2...
The protective effects of neferine against paracetamol-induced liver injury are associated with the activation of SIRT1/Nrf2/HO-1 signaling pathway and inhibition of NF-kappa B/TNF-alpha/iNOS/COX-II cascade [0.03%]
小檗碱通过激活SIRT1/Nrf2/HO-1信号通路和抑制NF-κB/TNF-α/iNOS/COX-II级联反应对抗乙酰氨基酚致肝损伤的保护作用
Mohammed A Altowijri,Marwa E Abdelmageed,Randa El-Gamal et al.
Mohammed A Altowijri et al.
Drug-induced hepatotoxicity is a significant public health issue that influences the development of novel pharmaceutical therapies and the retraction of numerous promising medications from the market.Therefore, the current study investigate...
Acute and subacute dermal toxicity analysis of film forming topical spray of meloxicam: in vitro and in vivo studies [0.03%]
美洛昔康成膜喷雾剂的急性及亚急性皮肤毒性分析体外和体内研究
Harithasree Veerabomma,Vaskuri G S Sainaga Jyothi,Divya Atram et al.
Harithasree Veerabomma et al.
Meloxicam is used in the treatment of clinical mastitis to promote milk production. Therefore, in the present investigation, acute and sub-acute dermal toxicity of our prototype film-forming topical dermal spray of meloxicam was carried out...
Acute and sub-acute toxicological evaluation of a bioactive compound mixture in healthy Wistar rats [0.03%]
健康Wistar大鼠生物活性化合物急性及亚急性毒理学评估
Thushara Indika Sampath,Susanthi Jayasinghe,Anoja Priyadarshani Attanayake et al.
Thushara Indika Sampath et al.
The increasing interest in bioactive compounds necessitates a thorough understanding of their in vivo safety profiles before they are developed as therapeutic drug leads. The present study aimed to evaluate acute and sub-acute toxicological...
Cardioprotective effect of apigenin and carvedilol against isoproterenol-induced myocardial infarction in rats [0.03%]
染料木素和卡维地洛对异丙肾上腺素致大鼠心肌梗死的保护作用
Rehnuma Siddiquee,Tarique Mahmood,Vaseem Ahamad Ansari et al.
Rehnuma Siddiquee et al.
Myocardial infarction remains one of the leading causes of mortality and morbidity globally. While apigenin (AP), a trihydroxyflavone, and carvedilol, a beta blocker, have both been utilized in the treatment of cardiovascular diseases. Ther...
Synergistic hepatoprotection by supplementing Saussurea costus (falc.) lipsch and Glycyrrhiza glabra L. in combination against Diethylnitrosamine-induced liver damage in rats [0.03%]
Saussurea costus (falc.) lipsch和甘草(Glycyrrhiza glabra L.)联合给药对二乙基亚硝胺所致大鼠肝损伤的协同保护作用
Bisen Harsh,Rakesh Kumar,R K Asrani et al.
Bisen Harsh et al.
This study aims to evaluate the hepatoprotective effects of combined Saussurea costus and Glycyrrhiza glabra extracts against diethylnitrosamine (DEN)-induced hepatic damage in rats. In the present investigation, the in vivo experimental st...
A new perspective on the neurotoxic mechanisms of six typical per- and polyfluoroalkyl substances (PFAS): insights from integrating network toxicology and random forest algorithm [0.03%]
六种典型含氟物质神经毒作用机制的新视角：网络毒理学与随机森林算法整合分析的启示
Wei Cheng,Peng Lin,Zhina Yang et al.
Wei Cheng et al.
Per- and polyfluoroalkyl substances (PFAS) are widely used in various industries but pose significant ecological and human health risks, particularly to the nervous system. However, the underlying neurotoxic mechanisms remain poorly underst...
Potassium bromate-induced oxidative damage and nephrotoxicity in rats is ameliorated by vitamin C [0.03%]
维生素C改善溴酸钾致大鼠氧化损伤及肾毒性
Saima Nazir,Mir Kaisar Ahmad,Zubair- Ul-Nazir
Saima Nazir
Potassium bromate (KBrO3), a widely used food-additive and a major water disinfection by-product, causes severe toxicity in humans and experimental animals. Bromate is considered a probable human carcinogen and a complete carcinogen in anim...
Comparative histological, immunohistochemical, and biochemical effects of three orally administered fluoroquinolones in rats [0.03%]
三种口服氟喹诺酮类药物对大鼠组织学、免疫组织化学和生化的影响比较研究
Turan Yaman,Fatih Donmez,Abdulahad Dogan et al.
Turan Yaman et al.
Fluoroquinolones (FQs) are potent, broad-spectrum bactericidal antibiotics commonly used to treat infections in both humans and animals. Despite their therapeutic efficacy, their potential reproductive toxicity remains a concern. This study...
Butylated hydroxytoluene protects against sodium arsenite-induced hepatorenal toxicities: in vivo and in silico studies [0.03%]
丁基羟基苯甲醇保护钠三氧化二砷致肝肾毒性的体内和体外研究
A M Adegoke,S A Gazali,O O Latinwo et al.
A M Adegoke et al.
Arsenic is a global environmental contaminant. Sodium arsenite (NaAsO2), one of the arsenic compounds, is toxic. Prolonged exposure to NaAsO2 causes various detrimental effects on body organs. Butylated hydroxytoluene (BHT), a synthetic ant...