Evaluation of Hepatotoxic effects of azo dye Acid Red 119 in freshwater fish Channa punctata [0.03%]
酸性红119染料通过淡水鱼印度鲫生物评价的肝毒性效应
Harpal Kaur,Samriti Sharma,Pooja Chadha
Harpal Kaur
The existing study was conducted to evaluate the toxic potential of Acid Red 119 (AR 119) in fish Channa punctata by assessing DNA damage, biochemical alterations and histopathological changes in liver tissue after acute exposure. Fish were...
Evaluation of therapeutic effects of royal jelly versus Nigella sativa oil on some brain areas affected by acute methanol poisoning in rats [0.03%]
皇家蜂乳与黑种草子油对急性甲醇中毒大鼠某些脑区治疗效果的评价
Yasmien Morsy,Marwa Shahin,Eman Draz et al.
Yasmien Morsy et al.
Methanol (CH3OH) is one of the toxic alcohols that has high morbidity and mortality. It causes lipid peroxidation and oxidative stress. Antioxidants and neuroprotective agents could have therapeutic roles in case of methanol exposure. The a...
Quinestrol nanoparticle-based formulation for long-term oral contraception against the wild female rats, Bandicota bengalensis [0.03%]
用于长期口服避孕的喹雌醇纳米颗粒制剂对抗野生雌性孟加拉家鼠（Bandicota bengalensis）
Dimple Mandla,Neena Singla,Anu Kalia et al.
Dimple Mandla et al.
This study developed and evaluated a ready-to-use quinestrol nanoparticle-based bait for contraception in female Bandicota bengalensis (lesser bandicoot rat). B. bengalensis in three treatment groups: Control (plain bait), Q (bait with bulk...
Network toxicology and machine learning reveal key molecular targets and pathways of mono-2-ethylhexyl phthalate-induced atherosclerosis [0.03%]
网络毒理学和机器学习揭示环境内分泌干扰物Mono-2-乙基己基苯二甲酸盐诱导动脉粥样硬化的关键分子靶点及作用通路
Qiu Sun,Gang Zhao
Qiu Sun
Mono-2-ethylhexyl phthalate (MEHP), a major metabolite of diethylhexyl phthalate, is increasingly recognized as an environmental contaminant with potential cardiovascular toxicity. However, the molecular mechanisms underlying MEHP-induced a...
Acute and subacute oral toxicity of acetylated Ligubtrum lucidum Ait. polysaccharide in male mice [0.03%]
石菖蒲亮叶多糖乙酸酯对雄性小鼠的急性及亚急性经口毒性作用研究
Yanli Xi,Mingyang Huo,Rixin Zang et al.
Yanli Xi et al.
Ligustrum lucidum polysaccharide (FLL-P) is a class of important bioactive macromolecules extracted from the traditional Chinese medicinal herb wine-steamed Ligustrum lucidum Ait. As one of the key active components responsible for the phar...
The effect on paraoxonase and arylesterase activities of bee pollen against deltamethrin in Cyprinus carpio [0.03%]
蜜蜂花粉对鲤鱼毒死蜱胁迫下的PARAOXONASE和ARYLESTERASE活性的影响
Mücahit Eroğlu,M Enis Yonar,Serpil Mişe Yonar et al.
Mücahit Eroğlu et al.
This study aimed to determine whether dietary bee pollen protects common carp (Cyprinus carpio) from deltamethrin (DM)-induced oxidative stress by modulating serum paraoxonase (PON) and arylesterase (ARE) activities. DM, a widely used pyret...
Tert-butylhydroquinone attenuates anticancer drug paclitaxel-induced nephrotoxicity via inhibition of inflammation-mediated NF-κB/IL-6//TNF-α and modulation of oxidative stress-dependent Nrf2/caspase-3/GPX-4 signaling in rats [0.03%]
叔丁基对苯二酚通过抑制NF-κB/IL-6和TNF-α介导的炎症及调节Nrf2/caspase-3/GPX-4信号依赖性氧化应激在大鼠体内减轻抗肿瘤药物紫杉醇诱导的肾毒性
Nwaeze G Konyefom,Tawakalitu B Aliu,Zainab H Almansour et al.
Nwaeze G Konyefom et al.
Paclitaxel (PTX) is an efficacious natural product-derived anticancer agent. It exerts a remarkable disruption of nanopore microtubule dynamics, thus inducing cytotoxic effects on cancer cells. However, its drawback is associated with non-t...
Pharmacological synergistic multi-target of Curcuma longa compounds to minimise the ototoxic effects and resistance of cisplatin in ovarian cancer treatment: integration of bibliometric analysis, pharmacological networking, and molecular docking approaches [0.03%]
基于黄姜化合物的药理协同多靶点作用将顺铂耳毒副作用和耐药性最小化用于卵巢癌治疗：文献计量分析、药理网络及分子对接方法整合
Wahyu Hendrarti,Abdul Halim Umar,Brent Brenklyn Yantandi et al.
Wahyu Hendrarti et al.
This study explores the pharmacological synergy between Curcuma longa (turmeric) compounds and cisplatin in ovarian cancer treatment, focusing on overcoming drug resistance and minimizing toxicity. Using bibliometric analysis with tools lik...
Hepatoprotective effects of cirsimaritin against CCl4-induced oxidative stress, inflammation, and apoptosis in rats [0.03%]
cirsimaritin对抗CCl4诱导的氧化应激、炎症和细胞凋亡的肝保护作用
Yousra Bseiso,Badriyah S Alotaibi,Alaa A A Aljabali et al.
Yousra Bseiso et al.
Background: Carbon tetrachloride (CCl4) induces hepatotoxicity through oxidative stress, inflammation, and apoptosis. Cirsimaritin, a natural flavonoid with antioxidant and anti-inflammatory activity, has not been extensi...
Insight on toxicity mechanisms of Datura metel L. seeds: a 28-day repeated dose study, in-silico studies, and effect of Shodhana a traditional detoxification method [0.03%]
曼陀罗籽毒理机制的洞察：28天重复给药研究、计算机模拟研究及其传统解毒方法沙德汉那（Shodhana）的效果研究
Shamanand P Mallapur,Banappa S Unger,Mrityunjay B Patil et al.
Shamanand P Mallapur et al.
Datura metel L., a poisonous medicinal plant is used safely after Shodhana in Ayurveda. It is listed in Schedule E1 of Drugs and Cosmetics Act, as a poisonous medicinal plant to be used with caution. Although known for its toxic effects and...