Propolis ameliorates thioacetamide induced hepatic fibrosis in rats: an in vivo and in silico approach [0.03%]
肉桂(propolis)通过体内和体外实验改善偏三甲基硅基丙烯酰胺引起的肝纤维化
Shubham Singh,Satendra Kumar Nirala,Prashant Singh et al.
Shubham Singh et al.
Propolis or bee glue is a resinous mixture with several biological properties, which is collected by honey bees from flowers and plants sap. The current study was carried out to ascertain whether propolis provides defence against thioacetam...
In vivo hepatic effects and post-exposure recovery following polyethylene terephthalate microplastic ingestion in Swiss Albino mice (Mus musculus) [0.03%]
聚对苯二甲酸乙二醇酯微塑料摄入的体内肝脏效应及暴露后的恢复：瑞士白小鼠模型研究
Mayuri Manoj Verlekar,Ankit Anand Sinha,Avelyno H D&#x;Costa
Mayuri Manoj Verlekar
The study focuses on the in vivo toxicity of two concentrations of Polyethylene Terephthalate (PET) microplastics (MPs) (average size 30.22 ± 10.21 µm; 1 mg/mL and 2 mg/mL in distilled water) in Swiss Albino mice after 14 days of exposure...
In vivo and in silico toxicity profiling of a novel 1,5-benzodiazepine derivative [0.03%]
一种新型1,5-苯并二氮杂衍生物的体内和体外毒性评价
Hanane El Fatimi,Hanane Khalki,Mohamed Loughzail et al.
Hanane El Fatimi et al.
Benzodiazepines (BZDs) are widely used but are often associated with significant side effects such as amnesia, dependence, and withdrawal syndrome, prompting the search for safer alternatives. The current study aimed to assess the possible ...
Lipid profile, toxicity, and antioxidant potential of flavonoid-rich babassu mesocarp extract after simulated human digestion [0.03%]
模拟人体消化对富含黄酮类物质的巴巴苏果肉提取物的脂质谱系、毒性及抗氧化潜力的影响
N Debia,A M Nunes,M L L B do Nascimento et al.
N Debia et al.
The babassu (Attalea speciosa Mart. ex Spreng, syn. Orbignya phalerata Mart), native to Brazil, is valued for its medicinal properties. Babassu mesocarp flour has attracted interest for its high flavonoid content. Given the antioxidant effe...
Comprehensive toxicological safety assessment of Trichosanthes kirilowii seeds as a candidate for new food resource [0.03%]
栝楼种子作为新食品资源的安全性评价研究
Li Wei-Wen,Su Yong,Li Pan et al.
Li Wei-Wen et al.
Semen Trichosanthis (ST), derived from Trichosanthes kirilowii seeds, has been traditionally used in ancient China to clear heat, resolve phlegm, moisten lungs, and relieve cough. Despite its therapeutic potential, systematic safety data re...
Multibiomarker assessment of the ecotoxic effects of naproxen in African fresh water catfish (Clarias gariepinus) juveniles [0.03%]
用多生物标志物评估萘普生对非洲鲶鱼幼鱼生态毒性的效应
Temitope Dadewura Melefa,Christopher D Nwani,Ifeanyi O Aguzie et al.
Temitope Dadewura Melefa et al.
Pharmaceutical contamination of the aquatic ecosystem has become an emerging challenge because of their impact on non-target aquatic organism. The sub lethal effect of naproxen-a non-steroid anti-inflammatory drug was studied for 28 days in...
Galbanic acid mitigates hippocampal cell death and memory impairment in lead-exposed prepubertal rats via antioxidant mechanisms [0.03%]
天竺桂酸通过抗氧化机制缓解铅暴露幼鼠海马细胞死亡和记忆障碍
Mohammad Hadi Zarei,Zahra Shirvani,Elham Saghaei et al.
Mohammad Hadi Zarei et al.
The developmental neurotoxicity of lead, a result of its adverse effects on the developing nervous system, is associated with various mechanisms. One such mechanism involves the disturbance of the equilibrium between pro-oxidants and antiox...
Possible genotoxic effects of dapagliflozin using SMART and comet tests, and behavioral toxicity in Drosophila melanogaster [0.03%]
使用SMART和彗星试验检测达格列净的潜在遗传毒性以及其对Drosophila melanogaster的行为影响
Arzu Özkara,Zebiha Yiğit,Dilek Akyıl et al.
Arzu Özkara et al.
Dapagliflozin (DAPA) is a sodium-glucose cotransporter (SGLT) inhibitor used in the treatment of type 2 diabetes mellitus. DAPA, used in the treatment of type 2 diabetes mellitus (T2DM), has been shown to cause liver damage in clinical stud...
Decabromodiphenyl ethane as a neurotoxicant in Alzheimer's disease: unraveling its mechanisms through the integration of multiple computational toxicology methods [0.03%]
十溴二苯乙烷作为阿尔茨海默病神经毒性物质：通过多种计算毒理学方法整合揭示其机制
Jixin Li,Jiatong Liu,Mo Zhou et al.
Jixin Li et al.
The role of environmental pollutants as risk factors for Alzheimer's disease (AD) and related neurodegenerative pathologies necessitates mechanistic investigation. Evidence implicates brominated flame retardants (BFRs)-decabromodiphenyl eth...
Aspirin's therapeutic mechanism against diesel particulate matter-induced lung injury revealed by network pharmacology and experimental models [0.03%]
网络药理学和实验模型揭示阿司匹林对抗柴油颗粒物致肺损伤的治疗机制
Yajun Zhang,Bing Li,Hangbing Cao et al.
Yajun Zhang et al.
Occupational exposure to diesel particulate matter (DPM) poses significant risks of pulmonary injury, highlighting an urgent need for effective pharmacological intervention. This study aimed to systematically elucidate the protective mechan...