Oridonin reduces cisplatin-induced cardiac damage: targeting oxidative stress and inflammation in chemotherapy [0.03%]
桔梗素通过抗氧化应激和抗炎作用减轻顺铂引起的心脏毒性
Esam Qnais,Omar Gammoh,Yousra Bsieso et al.
Esam Qnais et al.
Cisplatin is a potent chemotherapeutic agent widely used in cancer treatment, known for its efficacy but limited by significant cardiotoxic side effects. Oridonin, a bioactive diterpenoid derived from Rabdosia rubescens, has demonstrated po...
Acute and subacute toxicity evaluation of a polyherbal blend in rats [0.03%]
一种复方草药制剂的急性与亚急性毒性评价研究rats模型
Prajakta H Murudkar,Akshay M Baheti,Anil T Pawar
Prajakta H Murudkar
Many people often assume the safety of herbs and use them in the form of polyherbal blends to treat various health conditions. The present study aimed to evaluate the acute and subacute oral toxicity profile of a polyherbal blend in Wistar ...
Phenytoin as an emerging pollutant on non-target aquatic invertebrates: effects on Lamellidens marginalis [0.03%]
苯妥英作为一种新兴的污染物对非靶标水生无脊椎动物的影响：唇足河蚌案例研究
Ashokkumar Sibiya,Chandrabose Selvaraj,Deepali Desai et al.
Ashokkumar Sibiya et al.
Pharmaceutical drugs have detrimental effects on aquatic organisms and change the ecological implications of the aquatic ecosystem. The present study was designed to examine the acute exposure (seven days) effect of phenytoin on the physiol...
Xenobiotic modalities impacting the thyroid 3H framework of hormonogenesis, homeostasis, and human health [0.03%]
xenobiotics影响甲状腺激素发生、稳态及人类健康的3氢结构模式
Abhishek Tater,Bharath Basavapattana Rudresh,Santosh L Gaonkar
Abhishek Tater
The thyroid gland is a central endocrine organ regulating growth, metabolism, and energy balance, and is increasingly vulnerable to interference by diverse xenobiotic compounds from pharmaceuticals, environmental pollutants, diet, and consu...
Carvacrol alleviates hepatorenal apoptosis in rats following exposure to lambda-cyhalothrin by targeting the Trx1/Prx1/Bcl2 pathway: in vivo and molecular docking studies [0.03%]
百里香酚通过靶向Trx1 / Prx1 / Bcl2途径缓解λ-氰戊菊酯致大鼠肝肾凋亡：体内和分子对接研究
Khairy A Ibrahim,Mohammed Eleyan,Mohamed Hussien et al.
Khairy A Ibrahim et al.
Lambda-cyhalothrin (LCT), a type II pyrethroid, is known to cause several side effects, including hepatorenal toxicity, despite its widespread use. This study investigates the protective effect of carvacrol (CVR) against LCT-induced oxidati...
In-silico toxicity assessment of polychlorinated naphthalenes in water ecosystem by Monte Carlo-based QSAR studies [0.03%]
基于蒙特卡罗的QSAR研究在水生态系统中多氯化萘的毒性评价
Kusum,Gulshan Singh,Anjali Ahlawat et al.
Kusum et al.
The bio-accumulative nature of polychlorinated naphthalenes (PCNs) due to their slow biodegradation raise concerns regarding adverse effects on aquatic organisms and potential human health risks through trophic transfer. The persistent and ...
Pharmacological and toxicological effects of paracetamol: current knowledge and a review [0.03%]
扑热息痛的药理和毒理作用：目前的研究进展与综述
Gulshan Athbhaiya,Aarti Tiwari,Rajesh Choudhary et al.
Gulshan Athbhaiya et al.
Paracetamol, commonly referred to as acetaminophen, is a widely used pain reliever and fever reducer. It is effective in treating mild to moderate pain and fever. The drug's mechanism of action involves inhibition of prostaglandin synthesis...
N-nitrosodimethylamine increased glucose production by promoting hyperglycemia in hepatocyte via AMPK signaling pathway in vivo and in vitro [0.03%]
N-亚硝基二甲胺通过AMPK信号通路在体内外促进肝细胞糖生成和高血糖症
Wenxin Wang,Shuhua Xi,Yue Wang
Wenxin Wang
N-nitrosodimethylamine (NDMA), as a disinfection by-product of drinking water, has been detected in various water. Epidemiological investigations have found that exposure to NDMA can exacerbate the development of diseases related to insulin...
Schiff Base Complex rescues mice against scopolamine-induced cognitive dysfunction [0.03%]
Schiff碱化合物复合物可缓解东莨菪碱致小鼠认知障碍
Saima Noreen,Ruqia Nazir,Muslim Khan et al.
Saima Noreen et al.
Alzheimer's disease (AD) is a common and debilitating neurodegenerative disease characterized by progressive cognitive impairment, and oxidative stress is a recognized contributor. Despite numerous studies, effective treatments remain scarc...
From folk remedy to toxic emergency: a case of acute abrin toxicity [0.03%]
从民间偏方到中毒急症——一例急性相思子毒性的病例报告
Ahmed Maher Ali,Nermin Hamdy Zawilla,Aisha Mohamed Samir et al.
Ahmed Maher Ali et al.
Introduction: Abrus precatorius (rosary pea) contains abrin, a highly potent ribosome-inhibiting toxin. Its seeds are well-known to be toxic when chewed or crushed, while boiled seed decoctions are occasionally used in tr...