Dose-dependent nephrotoxicity of hexaconazole following subchronic exposure in Swiss albino mice [0.03%]
高效氯唑慢性暴露对瑞士小白鼠的剂量依赖性肾毒性研究
Sonal Sharma,Geeta Pandey
Sonal Sharma
Hexaconazole (HEX), a triazole fungicide extensively used in agriculture, raises concerns due to its potential nephrotoxicity. This study assessed the dose-dependent effects of HEX on kidney structure and function in Swiss albino male mice....
Integrating computational chemistry, network pharmacology and in vitro experimental assays for deciphering the antitumor effects of naturally occurring sesquiterpene lactone-parthenolide in human oral carcinoma cells [0.03%]
计算化学、网络药理学及体外实验联用解析倍半萜内酯帕滕醇ides对人类口腔癌细胞的抗肿瘤作用机制
Fangyuan Wang,Qing Zhou,Qiuzi Wang
Fangyuan Wang
This study evaluates the anticancer efficacy of Parthenolide against SCC-9 oral squamous cell carcinoma cells using an integrated in silico and in vitro strategy. Pharmacokinetic behavior and drug-likeness were predicted using SwissADME, wh...
Evaluation of plasticizer toxicity effects and mechanisms in gastric cancer based on network toxicology and molecular docking [0.03%]
基于网络毒理学和分子对接评估增塑剂的毒性效应及机制在胃癌中的作用
Ning Tang,Jingke Zhang,Zhe Jiang et al.
Ning Tang et al.
The hypothesized toxicity and potential molecular mechanism of gastric cancer induced by exposure of two plasticizers (DBP and DEP) were studied by network toxicology. Potential relevant targets were predicted through PharmMapper, SwissTarg...
Impact of placental polycyclic aromatic hydrocarbons accumulation on neonatal birth outcomes [0.03%]
胎盘多环芳烃蓄积对新生儿结局的影响
Priyanka Agarwal,Madhu Anand,Shikha et al.
Priyanka Agarwal et al.
Although polycyclic aromatic hydrocarbons (PAHs) are recognized for their carcinogenic, teratogenic, and genotoxic properties, there is a lack of scientific evidence detailing impact of in-utero exposure to PAHs on adverse birth outcomes. P...
Developmental and reproductive toxicity studies of Hydroxysafflor Yellow a in Sprague-Dawley rats [0.03%]
羟基丹参黄色素A的发育毒性和生殖毒性研究
Shidong Qiu,Xiue Li,Xiaobo Wang et al.
Shidong Qiu et al.
This study aimed to evaluate the developmental and reproductive toxicity of HSYA across three segments (FEED, EFD, and PPND). HSYA was administered intravenously to Sprague-Dawley (SD) rats at doses of 25, 75, or 250 mg/kg. FEED: In the 250...
Neurotoxicity of chemotherapeutic agents: mechanisms and mitigation strategies [0.03%]
化疗药物的神经毒性：机制与缓解策略
Debasmita Ghosh,Dipanjan Karati
Debasmita Ghosh
Chemotherapeutic drugs have neurotoxic consequences even if they are used to treat cancer. Peripheral neuropathy, cognitive impairment, neuropathic pain, seizures, encephalopathy, and other symptoms may be present. According to studies cond...
Synthesis and multidimensional investigation of a tetra-substituted imidazole derivative: Spectroscopy, DFT/NLO properties, toxicity analysis, molecular docking, and dynamics simulation [0.03%]
四取代咪唑衍生物的合成及其多维度研究：光谱、DFT/NLO 性质、毒性分析、分子对接及动力学模拟
R Madhu Babu,Natrayan Lakshmaiya
R Madhu Babu
A novel tetra-substituted imidazole derivative (BDIM) was synthesized via a one-pot, four-component condensation reaction using BF3 as a Lewis acid catalyst. The experimental FT-IR,1H- and 1³C-NMR spectra show a very good match with the DF...
DNA damage induced by fungicides triadimefon, triadimenol, and their mixture in human lymphocytes: cytogenotoxicity and computational analysis of metabolic pathways [0.03%]
三种杀菌剂及其混合物对人淋巴细胞的致染色体损伤作用及代谢途径计算分析
Amanda Silva Fernandes,Áureo Barbosa de Souza,Marcelino Benvindo de Souza et al.
Amanda Silva Fernandes et al.
Triadimefon (TF) and triadimenol (TN) are triazole fungicides widely used to prevent fungal infections in cereals, fruits, and other economically important crops. Their harmful effects on non-target organisms have been reported. This study ...
Triptolide-containing Tripterygium wilfordii tablet induces male reproductive toxicity via targeting the TGF-β1/Smad2/SF-1 signaling pathway [0.03%]
雷公藤内酯醇含片通过靶向TGF-β1/Smad2/SF-1信号通路诱导雄性生殖毒性
Li Guo,Yuanfang Fan,Xiaohui Su et al.
Li Guo et al.
Tripterygium wilfordii tablet (TWT) is a widely used therapeutic agent for rheumatoid arthritis, but its clinical utility is restricted by severe reproductive toxicity. This study aimed to elucidate the male reproductive toxic effects of TW...
Interest of biochemical monitoring of liver function for patients under anti-tuberculosis treatment [0.03%]
肝功能生化监测在结核病患者治疗中的意义分析研究进展
Alsayed Ahmad Dana,Chikhi Aicha,Sai Touba et al.
Alsayed Ahmad Dana et al.
Drug-induced hepatotoxicity (DIH) is an adverse reaction secondary to the administration of anti-tuberculosis (anti-TB) drugs. We aimed to evaluate the importance of implementing periodic liver function tests before and throughout the anti-...