Evidence of non-carcinogenicity of rhubarb extract: a 2-year feeding study in SD rats [0.03%]
番泻提取物无致癌性的证据：SD大鼠喂养两年研究结果
Liwen Zhou,Ji Liu,Wenxiang Yang et al.
Liwen Zhou et al.
This study evaluated the carcinogenicity and determined the no observed adverse effect level (NOAEL) of rhubarb extract in Sprague-Dawley (SD) rats over two years.SD rats (104 per group, equal males/females) were randomly assigned to a cont...
Evaluation of toxicological profile of omeprazole degradation impurities in an intravenous drug product: omeprazole-sulfone and omeprazole-N-oxide [0.03%]
评估埃索美拉唑输液剂降解杂质的毒性特征：砜和亚硝基代谢物毒理学研究
Engin Sumer,Muhammed Hamitoğlu,Gulcin Tugcu et al.
Engin Sumer et al.
Omeprazole (OMZ) is a widely used proton pump inhibitor for the treatment of acid-related gastrointestinal disorders. Degradation during the manufacture and storage of the drug substance or drug product may lead to the formation of impuriti...
Topiramate exacerbates liver damage: a study on NAFLD, nitrosative stress and apoptosis [0.03%]
托吡酯加重肝损伤：一种针对NASH、硝基化应激及凋亡的研究
Sevtap Kılınç,Pelin Şahin,Zeynep Yığman et al.
Sevtap Kılınç et al.
Nonalcoholic fatty liver disease (NAFLD) is a common comorbidity of obesity. Topiramate (TPM) is an anti-obesity drug. Previously, TPM showed oxidative effect to the liver. On the other hand, its effect on nitrosative stress, inflammation, ...
Pubertal atrazine exposure promotes adipocyte hypertrophy and hepatic steatosis in adult mice on a high-fat diet [0.03%]
青春期暴露于阿特拉津会促进高脂肪饮食小鼠的肥胖和肝脂变性
Jakeline Liara Teleken,Isabela Carolina Menoncin Conte,Gabriel Schorr et al.
Jakeline Liara Teleken et al.
The herbicide atrazine (ATZ) has been implicated in metabolic disruptions. This study investigated the long-term consequences of pubertal ATZ-based herbicide exposure on the development of obesity in mice fed a high-fat diet (HFD) in adulth...
Effects of tris(2-chloroethyl)phosphate on hyperuricemia revealed by network toxicology and in vitro experimental validation [0.03%]
三(2-氯乙基)磷酸酯通过网络毒理学和体外实验验证对高尿酸血症的影响研究
Yongxiao Huang,Caina Jiang,Fangyao Li et al.
Yongxiao Huang et al.
As a commonly used flame retardant in numerous products, it is inevitable that tris(2-chloroethyl)phosphate (TCEP) is released into the surrounding environment during its use. This process gives rise to potential environmental concerns that...
Tadehaginoside improves liver fibrosis in mice by inhibiting the activation of hepatic stellate cells mediated by the molecular axis of miR-155/FOXO3 [0.03%]
苔黑素通过miR-155/FOXO3分子轴抑制肝星状细胞活化改善小鼠肝纤维化
Aicun Tang,Luying Wei,Jiayi Gao et al.
Aicun Tang et al.
To analyze tadehaginoside (TA) for its effect on liver fibrosis and the associated mechanism. Mice with CCl4-mediated liver fibrosis were administered TA treatment for 6 weeks. Histopathological alterations in liver tissues were evaluated, ...
Computational design and evaluation of low-toxicity saquinavir analogues targeting the catalytic dyad and oxyanion-hole loop of SARS-CoV-2 Mpro: insights from ensemble docking, molecular dynamics, dynamic undocking, and ADMET analysis [0.03%]
计算设计和评估低毒性沙奎那韦类似物以靶向SARS-CoV-2 Mpro的催化二元体和亲核洞环：从系综对接、分子动力学、动态解离和ADMET分析中获得的见解
Kranthi Kumar Konidala,Umadevi Bommu,Suneetha Yeguvapalli
Kranthi Kumar Konidala
A myriad of therapeutic candidates targeting SARS-CoV-2 have entered clinical trials; however, the ongoing challenges in SARS-CoV-2 drug discovery, such as adverse effects associated with some therapeutic candidates, necessitate continuous ...
Acute and subacute toxicity of ethanol leaf extract of Urtica simensis Hochst. ex A. Rich in rats [0.03%]
埃塞俄比亚刺叶乌头草（Urtica simensis）的乙醇提取物对大鼠的急性和亚急性毒性研究
Bickes Wube,Kaleab Asres,Worku Gemechu et al.
Bickes Wube et al.
Urtica simensis is a native nutraceutical herb in Ethiopia, but its safety of repeated oral intake has not been reported yet. This study aimed to evaluate acute and subacute toxicity of ethanol leaf extract of U. simensis in rats. The media...
Heavy metal mixture induced hippocampal toxicity involve biometal accumulation, increase in oxidative stress, inflammation, and caspase-3 activation in rats via Nrf-2/HO-1/BDNF pathway [0.03%]
重金属混合物诱导的大鼠海马毒性作用涉及生物金属蓄积、氧化应激、炎症和Nrf-2/HO-1/BDNF通路介导的caspase-3活化增加
Baridoo Donatus Dooka,Chinna N Orish,Anthonet N Ezejiofor et al.
Baridoo Donatus Dooka et al.
Exposure to heavy metal mixtures HMM can elicit significant health risks due to their combined toxic effects. This study investigates the mechanisms of hippocampal toxicity associated with HMM exposure. Rats were exposed to lead (Pb) 20, al...
Kidney damage following a 90-day subchronic inhalation exposure to HTP aerosol in SD rats [0.03%]
90天空气吸入暴露对烟草加热系统制品气溶胶SD大鼠肾脏毒性研究
Yushan Tian,Hongjuan Wang,Yaning Fu et al.
Yushan Tian et al.
Cigarette smoking (CS) was reported to induce the risk of renal diseases. However, heated tobacco product (HTP), a modified risk tobacco product, was claimed to reduce exposure risk, its health risk of kidney was still unclear. In this stud...