Metabolic dysfunction-associated fatty liver disease and risk of hypertension in young adults: A cross-sectional study mediated by inflammatory markers [0.03%]
代谢功能紊乱相关脂肪肝病通过炎症标志物对年轻人高血压风险的影响：一项横断面研究
Jia Zheng,Chengzhi Lu
Jia Zheng
Objective: This study aimed to investigate the prevalence of hypertension among young adults with MAFLD, assess the association between the presence and severity of MAFLD and hypertension, and explore potential mediating ...
Iron status mediates the causal effects of high-altitude adaptation signals in the HIF-PHD axis on pulmonary vascular and right-heart outcomes [0.03%]
铁状态介导低氧适应基因变异通过HIF-PHD轴对肺血管和右心室功能影响的因果效应
Youqian Zhang,Chang Liu,Jiejun Zhou et al.
Youqian Zhang et al.
Background: The high-altitude adaptation genes EPAS1 (HIF-2α) and EGLN1 (PHD2) in the HIF-PHD oxygen-sensing pathway regulate erythropoiesis and iron homeostasis and are implicated in hypoxia-related pulmonary vascular d...
Hypertension and Alzheimer's disease: Pathological interplay, comorbidity risks, and new strategies for synergistic management [0.03%]
高血压和阿尔茨海默病：病理相互作用、共病风险及协同管理的新策略
Xinyu Wei,Lili Li,Guohua Zhao et al.
Xinyu Wei et al.
Hypertension and Alzheimer's disease (AD) are common comorbidities that seriously damage the health of the elderly. This review lays out the complex bidirectional association between hypertension and AD. From a pathological perspective, hyp...
New insights into clinical strategies for acute coronary syndrome based on biomarker-driven multiomics research [0.03%]
基于生物标志物驱动的多组学研究指导的急性冠脉综合征临床策略新见解
Zhixuan Zhao,Keying Yu,Yuetong Zhao et al.
Zhixuan Zhao et al.
With rapid advancements in genomics, proteomics, and metabolomics researchers have gained significant insights into ACS (ACS) pathogenesis. Studies have revealed specific biomarkers linked to ACS and provided novel tools for risk evaluation...
Identification of endoplasmic reticulum stress-associated signatures of human pulmonary arterial hypertension: A bioinformatic analysis [0.03%]
人肺动脉高压内质网应激相关特征的生物信息学分析
Qiyu Zheng,Ziwen Zhao,Litao Wang et al.
Qiyu Zheng et al.
Pulmonary arterial hypertension (PAH) is a group of complex vasculopathies characterized by increased pulmonary arterial pressure and subsequent pulmonary vascular remodeling. However, the underlying pathogenesis of PAH has not been fully e...
Predictive model combining blood pressure, glycemic and renal markers for diabetic nephropathy in elderly hypertensive patients with type 2 diabetes [0.03%]
结合血压、血糖及肾功能指标预测2型糖尿病高血压老年人糖尿病肾病模型
Fengnian Guo,Li Qin,Baoguang Chen et al.
Fengnian Guo et al.
This retrospective cohort study assessed the predictive value of routine clinical indicators for diabetic nephropathy (DN) in elderly patients (≥60 years) with type 2 diabetes mellitus (T2DM) and hypertension. A total of 102 hospitalized p...
Interaction of circPcmtd1 with HSP90AB1 mediates phosphorylation of AKT to regulate pulmonary arterial hypertension induced by high pulmonary blood flow in rat [0.03%]
circPcmtd1通过与HSP90AB1互作介导AKT磷酸化调节高肺血流量诱发的大鼠肺动脉高压
Bingbing Ye,Danyan Su,Yuqin Huang et al.
Bingbing Ye et al.
This study was designed to elucidate the role of circPcmtd1 in regulating pulmonary artery smooth muscle cells (PASMCs) proliferation and migration, through the HSP90AB1/AKT signaling axis, in rats with high pulmonary blood flow-induced PAH...
Transcatheter hybrid closure of a large muscular ventricular septal defect with severe pulmonary hypertension using a duct occluder [0.03%]
使用动脉导管堵塞器封堵大的肌部室间隔缺损合并重度肺动脉高压
Shibiao Zhang,Mi Tang,Qin Wu et al.
Shibiao Zhang et al.
Background: Apical muscular ventricular septal defects (mVSDs) are surgically challenging because of their location. Although transcatheter device closure is effective in many patients, large apical defects in infants pre...
Gastrin signaling in cardiovascular pathophysiology: From molecular crosstalk to clinical implications [0.03%]
胃泌素信号在心血管病理生理学中的作用：从分子互作到临床意义
Chunmei Xu,Zhuxin Li,Yongchun Zeng et al.
Chunmei Xu et al.
As a gastrointestinal hormone, gastrin stimulates gastric acid secretion and intestinal mucosal nutrition. Evidence links it closely to coronary heart disease, ischemia‒reperfusion injury and hypertension. The relevant literature was syste...
Transcatheter adrenal artery ablation: A preclinical safety assessment in a porcine model [0.03%]
经导管肾上腺动脉消融：猪模型的临床前安全评估
Tao Luo,Anping Zeng,Gaomin He et al.
Tao Luo et al.
Background: Transcatheter adrenal artery embolization (TAAE) has emerged as a minimally invasive technique for selective adrenal ablation, offering potential therapeutic applications for various adrenal disorders. However...