Targeting the PHD2/HIF-1α/HO-1 pathway: A key role of trimetazidine in hypertensive nephropathy [0.03%]
靶向PHD2/HIF-1α/HO-1通路：曲美他嗪在高血压肾病治疗中的关键作用
Daqian Gu,Meixian Chen,Yuhui Yang et al.
Daqian Gu et al.
Objective: This study seeks to unravel the effects of trimetazidine (TMZ) on hypertensive nephropathy (HN) in mice and its underlying mechanisms. Methods:...
Investigating non-invasive hemodynamic indicators in hypertension patients with coronary atherosclerotic heart disease [0.03%]
高血压冠心病患者无创血流动力学指标的变化分析
Xiaofen Tian,Yuanlin Zou,Yuyang Zhou et al.
Xiaofen Tian et al.
Objective: To evaluate the clinical utility of non-invasive hemodynamic indicators in assessing cardiovascular risk among hypertensive patients with coronary atherosclerotic heart disease (CAD), and to explore their corre...
The causal relationship between aspartate aminotransferase and hypertension: A bidirectional Mendelian randomization study [0.03%]
天冬氨酸氨基转移酶和高血压之间的因果关系：一项双向孟德尔随机化研究
Hongyan Song,Jun Li,Lizhen Lan et al.
Hongyan Song et al.
Background: Hypertension is a major contributor to the global burden of disease and increased mortality in the general population. Currently, the etiology and pathogenesis of hypertension are not fully understood. Emergin...
Association between serum albumin to serum creatinine ratio and incident heart failure in patients with chronic kidney disease [0.03%]
慢性肾脏病患者血清白蛋白与肌酐比值与新发心力衰竭的关联研究
Weiwei Zhang,Youyou Liang,Peishan Xue et al.
Weiwei Zhang et al.
This prospective cohort study investigated the association between the albumin to serum creatinine ratio (sACR) and heart failure (HF) incidence in 150 chronic kidney disease (CKD) patients. Over a median 23-month follow-up, 114 HF events o...
Association of different diet quality scores with cardiovascular disease mortality risk in hypertension treatment group [0.03%]
不同膳食质量量表与高血压治疗患者心血管病死亡风险的相关性分析
Junfeng Zhou,Yingjie Su,Liudang He et al.
Junfeng Zhou et al.
Objective: This study investigated the association between several dietary quality scores-including the healthy eating index-2015(HEI-2015), dietary inflammatory index (DII), and dietary approaches to stop hypertension (D...
The effect of comprehensive intervention on children with anxiety/depression and increased blood pressure [0.03%]
综合干预对焦虑/抑郁伴血压增高的儿童的影响
Luxi Chen,Xin Wang,Lanmali Luo et al.
Luxi Chen et al.
Background: Psychological problems such as anxiety and depression in children show an increasing prevalence, but low treatment rates and few interventions have been implemented. The relationship between combined exercise ...
Randomized Controlled Trial
Clinical and experimental hypertension (New York, N.Y. : 1993). 2025 Dec 31;47(1):2560635. DOI:10.1080/10641963.2025.2560635 2025
miPEP31 inhibits the vascular smooth muscle cell proliferation via cooperation with transcription factor Trps1 [0.03%]
miPEP31通过与转录因子Trps1协作抑制血管平滑肌细胞增殖
Gonghao Jiang,Xiangxiao Li,Zilong Fang et al.
Gonghao Jiang et al.
Our previous study has found that miPEP31, which is encoded by pri-miRNA-31, inhibits the transcription of pri-miRNA-31 and alleviates angiotensin (Ang) II-induced hypertension. miR-31 is involved in proliferation of primary vascular smooth...
Hypertension accelerates aging: Evidence from NHANES database and Mendelian randomization analyses [0.03%]
高血压会加速衰老：来自NHANES数据库和孟德尔随机化分析的证据
Zhaobin Sun,Gaoying Dai,Nanhu Quan
Zhaobin Sun
Background: Hypertension is thought to accelerate biological aging. However, evidence of a causal effect is lacking. This study aimed to provide evidence of a relationship between hypertension and biological aging by anal...
Genetic causal assessment between major depression and hypertension: A two-sample bidirectional Mendelian randomization study [0.03%]
基于孟德尔随机化方法评估抑郁症和高血压之间的遗传病因关系：双向两样本孟德尔随机对照研究
Yani Su,Ming Zhang,Peng Xu et al.
Yani Su et al.
Objective: The concurrent prevalence of major depression and hypertension represents a significant clinical concern. This study aims to investigate the potential causal relationship among these conditions from a genetic s...
Neuroprotective peptide OL-FS13 attenuates cardiac apoptosis and myocardial infarction injury through Nrf2/HO-1 pathway [0.03%]
神经保护肽OL-FS13通过Nrf2/HO-1信号通路抑制心肌细胞凋亡和心肌梗死损伤
Hao Wang,Ke Zhou,Xiaoling Chen et al.
Hao Wang et al.
Myocardial infarction (MI) is a leading cause of morbidity and mortality globally, primarily due to oxidative stress-induced cardiomyocyte apoptosis and adverse cardiac remodeling. OL-FS13, a neuroprotective peptide derived from Odorrana li...