Fred Sanfilippo
Fred Sanfilippo
Receiving guidance and help from mentors is an essential component of career development and planning, especially in academic medicine and biomedical research where the availability of resources and job opportunities are becoming more chall...
Peroxisome Proliferator-activated Receptor Agonist IVA337 Alleviates Inflammation and Fibrosis in MASH by Restoring Lipid Homeostasis [0.03%]
过氧化物酶体增殖激活受体激动剂IVA337通过恢复脂质稳态缓解MASH的炎症和纤维化
Na Li,Shuai Wu,Xiaodan Li et al.
Na Li et al.
Metabolic dysfunction-associated steatohepatitis (MASH), an advanced stage of metabolic dysfunction-associated steatotic liver disease (MASLD), is characterized by significant hepatic fibrosis and inflammation. The pan-peroxisome proliferat...
AHSA1/Hsp90α complex facilitates microglial mitophagy by targeting TOMM70 in Parkinson's disease [0.03%]
AHSA1/Hsp90α复合体通过在帕金森病中靶向TOMM70促进小胶质细胞线粒体自噬
Liang Shao,Ji Zhang,Fan Hu et al.
Liang Shao et al.
Parkinson's disease (PD) is a commonly diagnosed neurodegenerative disease with rising prevalence globally. However, the pathology of PD remains largely undefined. The aim of this study is to get better understanding of microglial mitophagy...
Alcohol mediated skeletal muscle adaptations and their impact on comorbidities [0.03%]
酒精介导的骨骼肌适应及其对共病的影响
Keishla M Rodríguez-Graciani,Paticia E Molina,Liz Simon
Keishla M Rodríguez-Graciani
At-risk alcohol use has significant adverse effects on multiple tissue and organ systems, including the skeletal muscle. The pathophysiological mechanisms underlying alcohol-induced dysfunctional skeletal muscle mass are multifactorial, inv...
Parenchymal and Dyshoric Fibrillar Amyloid Pathology in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2 [0.03%]
rTg-D型脑淀粉样血管病小鼠模型中实质性和血管性原纤维淀粉样病变病理学分布特征研究
Joseph M Schrader,Feng Xu,Xiaoyue Zhu et al.
Joseph M Schrader et al.
Cerebral amyloid angiopathy (CAA) is a common disorder of the elderly, prominent comorbidity of Alzheimer's disease (AD), and causes vascular cognitive impairment and dementia. Previously, a novel transgenic rat model (rTg-D) was generated ...
Mengmeng Zhang,Jingjing Ji,Jiayi Song et al.
Mengmeng Zhang et al.
ALD is a liver disorder induced by chronic excessive alcohol consumption, affecting approximately 3.5% of the global population. The spectrum of ALD encompasses simple steatosis, alcoholic hepatitis, fibrosis, cirrhosis, and the potential d...
Chronic alcohol consumption enhances the differentiation capacity of hematopoietic stem and progenitor cells into osteoclast precursors [0.03%]
慢性酒精消耗可增强造血干细胞和祖细胞向破骨前体细胞的分化能力
Hami Hemati,Madison B Blanton,Jude Koura et al.
Hami Hemati et al.
Chronic alcohol consumption (CAC) is associated with an enhanced risk of bone fracture, reduced bone density, and osteoporosis. Previous studies, using a rhesus macaque model of voluntary ethanol consumption, have shown that CAC induces fun...
This Month in AJP [0.03%]
本月AJP刊文报告
Chhavi Chauhan
Chhavi Chauhan
From Single-Cancer to Pan-cancer Prognosis: A Multi-modal Deep Learning Framework for Survival Analysis with Robust Generalization Capability [0.03%]
从单一癌症到泛癌生存预测：一种具有鲁棒泛化能力的多模态深度学习框架
Binyu Zhang,Shichao Li,Junpeng Jian et al.
Binyu Zhang et al.
Accurate prognosis represents a critical component in oncology research, enabling personalized treatment planning, and optimized healthcare resource utilization. While existing prognostic models demonstrate promising performance on restrict...