Katharine J Babcock,Bobak Abdolmohammadi,Ann C McKee
Katharine J Babcock
Exposure to repeated head impacts (RHI), such as those experienced in contact sports or military service, can lead to the development of chronic traumatic encephalopathy (CTE), a neurodegenerative tauopathy. CTE cannot be diagnosed during l...
Exploring Vascular Contributions to Cognitive Impairment: Small vessel disease of white matter and micro/nanoplastics [0.03%]
血管性认知障碍的血管因素：脑白质小血管病变和微/纳米塑料的作用
Elaine L Bearer
Elaine L Bearer
Cognitive impairment due to vascular pathology was recognized by Otto Binswanger in 1894, before Alois Alzheimer presented his findings in 1907. Vascular causes of cognitive impairment are likely due to a range of pathologies that are still...
Hyperactivation of TAK1 causes skeletal muscle pathology reminiscent of inflammatory myopathies [0.03%]
TAK1过度活化导致类似炎症性肌病的肌肉病理变化
Meiricris Tomaz da Silva,Anirban Roy,Ashok Kumar
Meiricris Tomaz da Silva
Loss of skeletal muscle mass and strength is a debilitating consequence of various chronic diseases, inflammatory myopathies, and neuromuscular disorders. Inflammation plays a major role in the perpetuation of myopathy in degenerative muscl...
Emerging Insights into Protein Post-Translational Modifications in Chlamydia-Host Interactions [0.03%]
衣原体感染中的蛋白质修饰及宿主响应的新认识
Xiang Luo,Xin Wang,Canming Hu et al.
Xiang Luo et al.
Chlamydia species are responsible for significant diseases in both humans and animals, with their infection processes involving complex interactions with host cells. Protein post-translational modifications (PTMs) have emerged as a critical...
miR-204-5p Mitigates Disc Degeneration via SKI-Mediated Modulation of Apoptotic Signaling and Matrix Remodeling in Nucleus Pulposus [0.03%]
microRNA-204-5p通过SKI介导的凋亡信号和基质重塑调节缓解椎间盘退变
Rui Ran,Chao-Yang Gong,Zuo-Long Wu et al.
Rui Ran et al.
Dysregulation of nucleus pulposus cells (NPCs) is a critical contributor to intervertebral disc degeneration (IDD). One characteristic of degenerated discs is the increased apoptosis of NPCs and the substantial degradation of the extracellu...
PARP-1 and PARP-2 in B-cell Lymphoma: Pathogenic Roles and Therapeutic Implications [0.03%]
B细胞淋巴瘤中聚ADP核糖聚合酶1和2的致病作用及治疗意义
Andrea Molina-Alvarez,Blanca Sanchez-Gonzalez,Luis Colomo et al.
Andrea Molina-Alvarez et al.
B-cell lymphomas represent a heterogeneous group of malignancies characterized by complex genetic, epigenetic, and microenvironmental alterations. Defects in the DNA damage response (DDR) are critical drivers of lymphomagenesis, creating th...
NSUN5 Mediates Resistance to Doxorubicin via Upregulation of DNA Damage Repair Proteins BRCA2 and BRIP1 in Colorectal Cancer [0.03%]
NSUN5通过上调DNA损伤修复蛋白BRCA2和BRIP1介导结直肠癌对多柔比星的耐药性
Yuanyuan Xu,Chao Qin,Mengrou Zhang et al.
Yuanyuan Xu et al.
Despite advancements in diagnosis and therapy, chemotherapy resistance and metastasis remain significant challenges for colorectal cancer (CRC) patients. Addressing resistance to cell death is crucial for improving cancer treatment outcomes...
Enhancement of TNFα-mediated hepatic apoptosis and liver injury by Hepatitis B virus surface antigen [0.03%]
乙型肝炎病毒表面抗原增强肿瘤坏死因子介导的肝脏细胞凋亡和肝损伤
Wei Liu,Yan-Ting Lin,Dong-Ge Han et al.
Wei Liu et al.
Tumor necrosis factor α (TNFα) is a highly pleiotropic cytokine with a variety of biological functions such as cell proliferation, metabolic activation, inflammatory response and cell death. TNFα can induce a variety of mechanisms to ini...
The Long Noncoding RNA TUG1 Is Down-Regulated in Osteonecrosis of the Femoral Head and Enhances the Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells by Stimulating the Wnt/β-Catenin Pathway [0.03%]
长非编码RNA TUG1在股骨头坏死中下调并通过刺激Wnt/β-catenin信号通路促进骨髓间充质干细胞的成骨分化
Xudong Duan,Jiewen Zhang,Yiwei Zhao et al.
Xudong Duan et al.
Osteonecrosis of the femoral head (ONFH) is an orthopaedic disease with multifaceted pathogenesis. The role of long noncoding RNA (lncRNA) taurine-up-regulated gene 1 (TUG1) in ONFH remains unexplored. Thus, lncRNA expression profiles in su...