Single-cell and spatial transcriptomics-based research reveals association between M2a macrophages and tumor spread through air spaces in lung adenocarcinoma [0.03%]
单细胞和空间转录组学研究揭示M2a巨噬细胞与肺腺癌肿瘤通过气腔播散之间的关联
Yun Ding,Han Zhang,Hui Wen et al.
Yun Ding et al.
Tumor spread through air spaces (STAS) is a pathological feature of lung cancer with prognostic significance, and it is also a cutting-edge hotspot in the clinical field of lung cancer. However, the current mechanisms underlying the occurre...
SCG2 transcriptionally activated by SP1 promotes nasal epithelial cell proliferation and epithelial mesenchymal transition [0.03%]
SP1转录激活的SCG2促进鼻上皮细胞增殖和上皮间质转化
Jiabin Zhan,Quan Qiu,Zhengling Chen et al.
Jiabin Zhan et al.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by a tendency to recur and poor prognosis, epithelial mesenchymal transition (EMT) and proliferation of nasal epithelial cells (NECs) play an important role in CRSwNP develo...
Growth differentiation factor 11 attenuates photoaging through ferroptosis pathway in SZ95 sebocytes [0.03%]
生长分化因子11通过SZ95皮脂细胞铁死亡途径缓解光老化
Ying Liu,Jingran Zeng,Xueyi Liu et al.
Ying Liu et al.
Sebaceous glands synthesize and secrete sebum, forming a protective barrier on the skin. However, prolonged exposure to ultraviolet (UV) radiation leads to glandular atrophy and reduced sebum production. This study investigated the impact o...
Interplay between Leptin and Stearoyl-CoA Desaturase 1 in Estrogen Receptor-positive Breast Cancer Cells [0.03%]
leptin和stearoyl-coa脱氢酶1在雌激素受体阳性乳腺癌细胞中的相互作用
Felice Maria Accattatis,Luca Gelsomino,Linda Manna et al.
Felice Maria Accattatis et al.
Obesity, a global health challenge, contributes to various cancers, including breast cancer (BC). Complex metabolic dysregulation marks the development of both BC and obesity. Here, the interplay between the obesity-derived adipokine leptin...
Dehydroepiandrosterone Prevents Collagen Loss by Regulating HIF-1α Expression and Mitophagy in Hypoxic Human Scleral Fibroblasts [0.03%]
脱氢表雄酮通过调节缺氧诱导因子-1α表达和线粒体自噬防治人巩膜成纤维细胞胶原丢失
Qi Zhang,Jing Chen,Haichun Li et al.
Qi Zhang et al.
Myopia progression and its associated complications, which can lead to vision impairment, primarily result from persistent abnormal elongation of the eye's axial length. The previous metabonomic analysis of intraocular fluids suggested intr...
Role of PD-L1 in Regulatory T Cell-Mediated Suppression of Corneal Neovascularization [0.03%]
PD-L1在调节性T细胞介导的角膜新生血管抑制中的作用
Shima Dehghani,Manuel Chacon,Katayoon Forouzanfar et al.
Shima Dehghani et al.
Corneal neovascularization (NV) leads to inflammation and fibrosis, thereby compromising visual acuity and corneal graft survival. Despite existing anti-angiogenic therapies, clinical outcomes remain suboptimal. This study explores the anti...
Low-potassium triggers tubular epithelial NLRP3/ASC-driven kidney inflammation independently of inflammasomes [0.03%]
低钾通过肾小管上皮NLRP3/ASC独立于炎症小体驱动肾脏炎性反应
Satoko Komori,Takanori Komada,Takayoshi Matsumura et al.
Satoko Komori et al.
Pathological potassium (K+) deficiency causes kidney inflammation and injury, known as hypokalemic nephropathy (HN), the underlying pathogenesis of which is obscure. NLRP3 inflammasomes are platforms that sense the reduction of intracellula...
Cross-Modality Learning for Predicting IHC Biomarkers from H&E-Stained Whole-Slide Images [0.03%]
利用H&E染色的全片图像预测IHC生物标志物的跨模态学习方法
Amit Das,Naofumi Tomita,Kyle J Syme et al.
Amit Das et al.
Hematoxylin and Eosin (H&E) staining is a cornerstone of pathological analysis, offering reliable visualization of cellular morphology and tissue architecture for cancer diagnosis, subtyping, and grading. Immunohistochemistry (IHC) staining...
Stromal SRD5A2 promotes prostate growth through WNT5A-LEF1-IGF1 signaling in benign prostatic hyperplasia [0.03%]
基底杆状肌动蛋白激活SRD5A2介导的WNT5A-LEF1-IGF1信号促进良性前列腺增生中的上皮生长
Christina Sharkey,Boqing Gu,Xingbo Long et al.
Christina Sharkey et al.
Steroid 5 alpha-reductase type 2 (SRD5A2) is a key enzyme in androgen metabolism and a pharmacologic target in benign prostatic hyperplasia (BPH). While SRD5A2 is known to mediate stromal-epithelial interactions that influence prostate grow...
The role of extracellular vesicle-derived miRNA in the atherosclerotic burden [0.03%]
动脉粥样硬化负担中的细胞外囊泡衍生的miRNA作用机制研究
Alessandra Stefania Rizzuto,Isabella Fichtner,Stefano Carugo et al.
Alessandra Stefania Rizzuto et al.
In the context of atheroma-related sequelae, the role of extracellular vesicles (EVs) continues to spike interest. Their ability to traffic molecular cargo between cells highlights their role in intercellular communication, and consequently...